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Publications 1987 2019

  • 62 Article
  • 7 Review Article
  • 1 Conference article
  • 1 Doctoral Thesis
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2019

MiR-107 inhibits CDK6 expression, differentiation, and lipid storage in human adipocytes

Ahonen, M. A., Haridas, P. A. N., Mysore, R., Wabitsch, M., Fischer-Posovszky, P. & Olkkonen, V. M., 5 Jan 2019, In : Molecular and Cellular Endocrinology. 479, p. 110-116 7 p.

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Molecular determinants of ER-Golgi contacts identified through a new FRET-FLIM system

Venditti, R., Rega, L. R., Masone, M. C., Santoro, M., Polishchuk, E., Sarnataro, D., Paladino, S., D'Auria, S., Varriale, A., Olkkonen, V. M., Di Tullio, G., Polishchuk, R. & De Matteis, M. A., Mar 2019, In : Journal of Cell Biology. 218, 3, p. 1055-1065 11 p.

Research output: Contribution to journalArticleScientificpeer-review

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol

Koponen, A., Arora, A., Takahashi, K., Kentala, H., Kivela, A. M., Jaaskelainen, E., Peranen, J., Somerharju, P., Ikonen, E., Viitala, T. & Olkkonen, V. M., Mar 2019, In : Biochimie. 158, p. 90-101 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLC beta 3 Catalysis: Targeting It Eradicates Leukemia Stem Cells

Zhong, W., Xu, M., Li, C., Zhu, B., Cao, X., Li, D., Chen, H., Hu, C., Li, R., Luo, C., Pan, G., Zhang, W., Lai, C., Wang, T., Du, X., Chen, H., Xu, G., Olkkonen, V. M., Lei, P., Xu, J. & 1 othersYan, D., 19 Feb 2019, In : Cell Reports. 26, 8, p. 2166-+ 21 p.

Research output: Contribution to journalArticleScientificpeer-review

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Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

Pekkinen, M., Terhal, P. A., Botto, L. D., Henning, P., Mäkitie, R. E., Roschger, P., Jain, A., Kol, M., Kjellberg, M. A., Paschalis, E. P., van Gassen, K., Murray, M., Bayrak-Toydemir, P., Magnusson, M. K., Jans, J., Kausar, M., Carey, J. C., Somerharju, P., Lerner, U. H., Olkkonen, V. M. & 3 othersKlaushofer, K., Holthuis, J. C. M. & Mäkitie, O., 4 Apr 2019, In : JCI INSIGHT. 4, 7, 20 p., 126180.

Research output: Contribution to journalArticleScientificpeer-review

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The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1

Venditti, R., Masone, M. C., Rega, L. R., Di Tullio, G., Santoro, M., Polishchuk, E., Serrano, I. C., Olkkonen, V. M., Harada, A., Medina, D. L., La Montagna, R. & De Matteis, M. A., Mar 2019, In : Journal of Cell Biology. 218, 3, p. 783-797 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Analysis of ORP2-knockout hepatocytes uncovers a novel function in actin cytoskeletal regulation

Kentala, H., Koponen, A., Kivelä, A. M., Andrews, R., Li, C., Zhou, Y. & Olkkonen, V. M., Mar 2018, In : FASEB Journal. 32, 3, p. 1281-1295 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk?

Olkkonen, V. M., Sinisalo, J. & Jauhiainen, M., 2018, In : Atherosclerosis. 272, p. 27-32 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

Kentala, H., Koponen, A., Vihinen, H., Pirhonen, J., Liebisch, G., Pataj, Z., Kivelä, A., Li, S., Karhinen, L., Jääskeläinen, E., Andrews, R., Meriläinen, L., Matysik, S., Ikonen, E., Zhou, Y., Jokitalo, E. & Olkkonen, V. M., Nov 2018, In : Cellular and Molecular Life Sciences. 75, 21, p. 4041-4057 17 p.

Research output: Contribution to journalArticleScientificpeer-review

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Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments

Pulli, I., Lassila, T., Pan, G., Yan, D., Olkkonen, V. M. & Törnquist, K., 2018, In : Cell Calcium. 72, p. 62-69 8 p.

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USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

Ruuth, M., Soronen, J., Kaiharju, E., Merikanto, K., Perttilä, J., Metso, J., Lee-Rueckert, M., Taskinen, M-R., Kovanen, P. T., Öörni, K., Olkkonen, V. M., Jauhiainen, M. S. & Laurila, P-P., 13 Dec 2018, In : Lipids in Health and Disease. 17, 11 p., 285.

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2017

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition

Mysore, R., Liebisch, G., Zhou, Y., Olkkonen, V. M. & Haridas, P. A. N., Oct 2017, In : Chemistry and Physics of Lipids. 207, p. 246-252 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Depletion of TM6SF2 disturbs membrane lipid composition and dynamics in HuH7 hepatoma cells.

Ruhanen, H., Haridas, P. A. N., Eskelinen, E-L., Eriksson, O., Olkkonen, V. M. & Käkelä, R., May 2017, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1862, 7, p. 676-685 10 p.

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MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes

Mysore, R., Ortega, F. J., Latorre, J., Ahonen, M., Savolainen-Peltonen, H., Fischer-Posovszky, P., Wabitsch, M., Olkkonen, V. M., Fernandez-Real, J. M. & Haridas, P. A. N., 1 Nov 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 11, p. 4001-4012 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2016

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity

Motazacker, M. M., Pirhonen, J., van Capelleveen, J. C., Weber-Boyvat, M., Kuivenhoven, J. A., Shah, S., Hovingh, G. K., Metso, J., Li, S., Ikonen, E., Jauhiainen, M., Dallinga-Thie, G. M. & Olkkonen, V. M., Jun 2016, In : Atherosclerosis. 249, p. 140-147 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes

Huttala, O., Mysore, R., Sarkanen, J. R., Heinonen, T., Olkkonen, V. & Ylikomi, T., Oct 2016, In : Cell and Tissue Research. 366, 1, p. 63-74 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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MicroRNA-192*impairs adipocyte triglyceride storage

Mysore, R., Zhou, Y., Sädevirta, S., Savolainen-Peltonen, H., Haridas, P. A. N., Soronen, J., Leivonen, M., Sarin, A-P., Fischer-Posovszky, P., Wabitsch, M., Yki-Jarvinen, H. & Olkkonen, V. M., Apr 2016, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1861, 4, p. 342-351 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease

Soronen, J., Yki-Järvinen, H., Zhou, Y., Sädevirta, S., Sarin, A-P., Leivonen, M., Sevastianova, K., Perttilä, J., Laurila, P-P., Sigruener, A., Schmitz, G. & Olkkonen, V. M., 2016, In : Physiological Reports. 4, 1, e12661.

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Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses

Aho, V., Ollila, H. M., Kronholm, E., Bondia-Pons, I., Soininen, P., Kangas, A. J., Hilvo, M., Seppala, I., Kettunen, J., Oikonen, M., Raitoharju, E., Hyotylainen, T., Kahonen, M., Viikari, J. S. A., Harma, M., Sallinen, M., Olkkonen, V. M., Alenius, H., Jauhiainen, M., Paunio, T. & 6 othersLehtimaki, T., Salomaa, V., Oresic, M., Raitakari, O. T., Ala-Korpela, M. & Porkka-Heiskanen, T., 22 Apr 2016, In : Scientific Reports. 6, 14 p., 24828.

Research output: Contribution to journalArticleScientificpeer-review

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2015

Impact of non-alcoholic fatty liver disease on liver volume in humans

Bian, H., Hakkarainen, A., Zhou, Y., Lundbom, N., Olkkonen, V. M. & Yki-Jarvinen, H., Feb 2015, In : Hepatology Research. 45, 2, p. 210-219 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Ligand-dependent localization and function of ORP-VAP complexes at membrane contact sites

Weber-Boyvat, M., Kentala, H., Peranen, J. & Olkkonen, V. M., May 2015, In : Cellular and Molecular Life Sciences. 72, 10, p. 1967-1987 21 p.

Research output: Contribution to journalArticleScientificpeer-review

OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity

Weber-Boyvat, M., Kentala, H., Lilja, J., Vihervaara, T., Hanninen, R., Zhou, Y., Peranen, J., Nyman, T. A., Ivaska, J. & Olkkonen, V. M., 15 Feb 2015, In : Experimental Cell Research. 331, 2, p. 278-291 14 p.

Research output: Contribution to journalArticleScientificpeer-review

OSBP-related protein family in lipid transport over membrane contact sites

Olkkonen, V. M., 2015, In : Lipid Insight. 8(S1)/2015, p. 1-9 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure

Kentala, H., Pfisterer, S. G., Olkkonen, V. M. & Weber-Boyvat, M., Jul 2015, In : Steroids. 99, B SI, p. 248-258 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

A vertebrate model for the study of lipid binding/transfer protein function: Conservation of OSBP-related proteins between zebrafish and human

Zhou, Y., Wohlfahrt, G., Paavola, J. & Olkkonen, V. M., 11 Apr 2014, In : Biochemical and Biophysical Research Communications. 446, 3, p. 675-680 6 p.

Research output: Contribution to journalArticleScientificpeer-review

PNPLA3 mediates hepatocyte triacylglycerol remodeling

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R. & Olkkonen, V. M., Apr 2014, In : Journal of Lipid Research. 55, 4, p. 739-746 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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2013

ABC-cassette transporter 1 (ABCA1) expression in epithelial cells in Chlamydia pneumoniae infection

Korhonen, J. T., Olkkonen, V. M., Lahesmaa, R. & Puolakkainen, M., 2013, In : Microbial Pathogenesis. 61-62, p. 57-61 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3

Lallukka, S., Sevastianova, K., Perttila, J., Hakkarainen, A., Orho-Melander, M., Lundbom, N., Olkkonen, V. M. & Yki-Järvinen, H., Apr 2013, In : Diabetologia. 56, 4, p. 886-892 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Egg Consumption and Risk of Bladder Cancer: A Meta-Analysis

Li, F., Zhou, Y., Hu, R., Hou, L., Du, Y-J., Zhang, X., Olkkonen, V. M. & Tan, W., 1 May 2013, In : Nutrition and Cancer. 65, 4, p. 538-546 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Involvement of Bicarbonate-Induced Radical Signaling in Oxysterol Formation and Sterol Depletion of Capacitating Mammalian Sperm During In Vitro Fertilization

Boerke, A., Brouwers, J. F., Olkkonen, V. M., van de Lest, C. H. A., Sostaric, E., Schoevers, E. J., Helms, J. B. & Gadella, B. M., Jan 2013, In : Biology of Reproduction. 88, 1, 18 p., 21.

Research output: Contribution to journalArticleScientificpeer-review

Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins

Vihervaara, T., Käkelä, R., Liebisch, G., Tarasov, K., Schmitz, G. & Olkkonen, V. M., Mar 2013, In : Biochimie. 95, 3, p. 538-547 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Muncl8b Is a Major Mediator of Insulin Exocytosis in Rat Pancreatic beta-Cells

Lam, P. P. L., Ohno, M., Dolai, S., He, Y., Qin, T., Liang, T., Zhu, D., Kang, Y., Liu, Y., Kauppi, M., Xie, L., Wan, W. C. Y., Bin, N-R., Sugita, S., Olkkonen, V. M., Takahashi, N., Kasai, H. & Gaisano, H. Y., Jul 2013, In : Diabetes. 62, 7, p. 2416-2428 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Nobelin palkinto solunsisäisen kalvoliikenteen tutkijoille

Ikonen, E. & Olkkonen, V., 2013, In : Duodecim. 129, 22, p. 2397-2398 2 p.

Research output: Contribution to journalArticleProfessional

Osbpl8 Deficiency in Mouse Causes an Elevation of High-Density Lipoproteins and Gender-Specific Alterations of Lipid Metabolism

Beaslas, O., Metso, J., Nissila, E., Laurila, P-P., Kaiharju, E., Batchu, K. C., Kaipiainen, L., Mäyränpää, M., Yan, D., Gylling, H., Jauhiainen, M. & Olkkonen, V. M., 15 Mar 2013, In : PLoS One. 8, 3, p. Article Number: e58856 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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2012

Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects

Soronen, J., Laurila, P-P., Naukkarinen, J., Surakka, I., Ripatti, S., Jauhiainen, M., Olkkonen, V. M. & Yki-Järvinen, H., 2012, In : BMC Medical Genomics. 5, 9, p. Article Number: 9 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Angiopoietin-Like 4 Mediates PPAR Delta Effect on Lipoprotein Lipase-Dependent Fatty Acid Uptake but Not on Beta-Oxidation in Myotubes

Robciuc, M. R., Skrobuk, P., Anisimov, A., Olkkonen, V., Alitalo, K., Eckel, R., Koistinen, H. A., Jauhiainen, M. & Ehnholm, C., 4 Oct 2012, In : PLoS One. 7, 10, p. e46212 13 p.

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Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

Sevastianova, K., Pereira Delgado e Santos, A., Kotronen, A., Hakkarainen, A., Makkonen, J., Silander, K., Peltonen, M. K., Romeo, S., Lundbom, J., Lundbom, N., Olkkonen, V. M., Gylling, H., Fielding, B. A., Rissanen, A. & Yki-Jarvinen, H., 1 Oct 2012, In : American Journal of Clinical Nutrition. 96, 4, p. 727-734 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)

Do, H. T., Tselykh, T. V., Mäkelä, J., Ho, T. H., Olkkonen, V. M., Bornhauser, B. C., Korhonen, L., Zelcer, N. & Lindholm, D., 2012, In : Journal of Biological Chemistry. 287, 16, p. 12602-12611 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments

Uusi-Rauva, K., Kyttälä, A., van der Kant, R., Vesa, J., Tanhuanpaa, K., Neefjes, J., Olkkonen, V. M. & Jalanko, A., 2012, In : Cellular and Molecular Life Sciences. 69, 12, p. 2075-2089 15 p.

Research output: Contribution to journalArticleScientificpeer-review

ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion

Nissila, E., Ohsaki, Y., Weber-Boyvat, M., Perttila, J., Ikonen, E. & Olkkonen, V. M., 1 Dec 2012, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1821, 12, p. 1472-1484 13 p.

Research output: Contribution to journalArticleScientificpeer-review

OSBP-Related Proteins (ORPs) in Human Adipose Depots and Cultured Adipocytes: Evidence for Impacts on the Adipocyte Phenotype

Zhou, Y., Robciuc, M. R., Wabitsch, M., Juuti, A., Leivonen, M., Ehnholm, C., Yki-Järvinen, H. & Olkkonen, V. M., 21 Sep 2012, In : PLoS One. 7, 9, p. Article Number: e45352 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Oxysterols and Their Cellular Effectors

Olkkonen, V. M., Béaslas, O. & Nissilä, E., 2012, In : Biomolecules. 2, 1, p. 76-103 28 p.

Research output: Contribution to journalArticleScientificpeer-review

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PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis

Perttilä, J., Huaman-Samanez, C., Caron, S., Tanhuanpaa, K., Staels, B., Yki-Järvinen, H. & Olkkonen, V., 2012, In : American Journal of Physiology: Endocrinology and Metabolism. 302, 9, p. E1063-E1069 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity

Beaslas, O., Vihervaara, T., Li, J., Laurila, P-P., Yan, D. & Olkkonen, V. M., 2012, In : Experimental Cell Research. 318, 15, p. 1933-1945 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability

Zhou, W., Zhou, Y., Li, S., Zhou, T., Ma, H., Wei, K., Li, H., Olkkonen, V. & Yan, D., 6 Jun 2011, In : Experimental Cell Research. 317, p. 2353-2363 11 p.

Research output: Contribution to journalArticleScientificpeer-review

OSBP-Related Protein 8 (ORP8) Regulates Plasma and Liver Tissue Lipid Levels and Interacts with the Nucleoporin Nup62

Zhou, T., Li, S., Zhong, W., Vihervaara, T., Béaslas, O., Perttilä, J., Luo, W., Jiang, Y., Lehto, M., Olkkonen, V. & Yan, D., 15 Jun 2011, In : PLoS One. 6, e21078, p. 1-12 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Sterol binding by OSBP-related protein 1L regulates late endosome motility and function

Vihervaara, T., Uronen, R-L., Wohlfahrt, G., Bjorkhem, I., Ikonen, E. & Olkkonen, V. M., Feb 2011, In : Cellular and Molecular Life Sciences. 68, 3, p. 537-551 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface

Zhou, Y., Li, S., Mäyränpää, M. I., Zhong, W., Bäck, N., Yan, D. & Olkkonen, V. M., 2010, In : Experimental Cell Research. 316, p. 3304-3316 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Regulation of exocytotic protein expression and Ca2+-dependent peptide secretion in astrocytes

Paco, S., Margeli, M. A., Olkkonen, V. M., Imai, A., Blasi, J., Fischer-Colbrie, R. & Aguado, F., Jul 2009, In : Journal of Neurochemistry. 110, 1, p. 143-156 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Growth Differentiation Factor-9 Induces Smad2 Activation and Inhibin B Production in Cultured Human Granulosa-Luteal Cells

Kaivo-Oja, N., Bondestam, J., Kämäräinen, M., Koskimies, J., Vitt, U., Cranfield, M., Vuojolainen, K., Kallio, J. P., Olkkonen, V. M., Hayashi, M., Moustakas, A., Groome, N. P., ten Dijke, P., Hsueh, A. J. W. & Ritvos, O., Feb 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 2, p. 755-762 8 p.

Research output: Contribution to journalArticleScientificpeer-review