Ville Paavilainen

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Phone+358294159929, +358504484600
Emailville.paavilainenhelsinkifi

PL 65 (Viikinkaari 1)
00014
Finland
Viikinkaari 5, Biocenter 2
00790 Helsinki
Finland

Research activity per year

External positions

Post-doctoral Researcher, University of California San Francisco

2008 → 2014

Fields of Science

1182 Biochemistry, cell and molecular biology

33 Article
4 Review Article
1 Chapter
1 Doctoral Thesis
More
- 1 Working paper

Lipid Scrambling Pathways in the Sec61 Translocon Complex
Javanainen, M., Šimek, J., Tranter, D., O’Keefe, S., Karki, S., Biriukov, D., Šachl, R. & Paavilainen, V. O., 5 May 2025, In: Journal of the American Chemical Society. 147, 19, p. 15970-15984 15 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity
Lowe, E., Anderl, J. L., Bade, D., Delgado-Martin, C., Dong, C., Fan, R. A., Fang, Y., Jiang, J., Johnson, H. W. B., Kempema, A., McGilvray, P., McMinn, D., Millare, B., Muchamuel, T., Poweleit, N., Qian, Y., Rehan, S., Scapin, G., Sugahara, A. & Tranter, D. & 10 others, Tuch, B., Wang, J., Wang, L., Whang, J. A., Zuno-Mitchell, P., Paavilainen, V. O., Park, E., Taunton, J., Kirk, C. J. & Anand, N. K., Aug 2025, In: Journal of Pharmacology and Experimental Therapeutics. 392, 8, 14 p., 103634.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells
Mattos, D. R., das Neves, W., Kitamura, T., Pradhan, R., Wan, X., da Hora, C. C., Tranter, D., Kazemi, S., Yu, X., Tripathy, N., Paavilainen, V. O., McPhail, K. L., Oishi, S., Badr, C. E. & Ishmael, J. E., 2024, In: Acs Pharmacology & Translational Science. 7, 6, p. 1823-1838 16 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Molecular view of ER membrane remodeling by the Sec61/TRAP translocon
Karki, S., Javanainen, M., Rehan, S., Tranter, D., Kellosalo, J., Huiskonen, J., Happonen, L. J. & Paavilainen, V., 20 Nov 2023, In: EMBO Reports. 24, 16 p., e57910.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Signal peptide mimicry primes Sec61 for client-selective inhibition
Rehan, S., Tranter, D., Sharp, P. P. P., Craven, G. B. B., Lowe, E., Anderl, J. L. L., Muchamuel, T., Abrishami, V., Kuivanen, S., Wenzell, N. A. A., Jennings, A., Kalyanaraman, C., Strandin, T., Javanainen, M., Vapalahti, O., Jacobson, M. P. P., McMinn, D., Kirk, C. J., Huiskonen, J. T. & Taunton, J. & 1 others, Paavilainen, V. O., 2023, In: Nature Chemical Biology. 19, p. 1054–1062 27 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File

2 Finished
7 Active

EU HE RIA VIGILANT / Paavilainen Ville
Paavilainen, V. (Project manager), Paatero, A. (Participant) & Tranter, D. (Participant)
European Commission
01/01/2025 → 31/12/2028
Project: EU Research and Innovation Actions (RIA)
Yliopiston profilointi 8 - DIVSOL - Humt
Airavaara, M. (Project manager), Eronen, J. T. (Project manager), Hietakangas, V. (Project manager), Huiskonen, J. (Project manager), Kaartinen, T. (Project manager), Kangasharju, J. (Project manager), Kouvonen, P. J. (Project manager), Martikainen, P. (Project manager), Mäkelä, J. (Project manager), Niemi, M. (Project manager), Ojanen, T. (Project manager), Pönkä, V. (Project manager), Ripatti, S. (Project manager), Räsänen, A. (Project manager), Simojoki, H. (Project manager), Sinnemäki, K. (Project manager), Suomalainen Wartiovaara, A. (Project manager), Toivonen, R. (Project manager), Toom, A. (Project manager), Björkroth, J. (Participant), Bärlund, J. C. (Participant), Enkavi, G. (Participant), Floréen, P. (Participant), Fogelholm, M. (Participant), Grönlund, H. (Participant), Heinonen, M. (Participant), Holmström, A.-R. (Participant), Hämäläinen, K. K. (Participant), Jahnukainen, M. (Participant), Jeltsch, M. (Participant), Juhola, S. (Participant), Kakouros, S. (Participant), Keskinen, S. (Participant), Khan, S. H. (Participant), Klami, A. (Participant), Korhonen, K. (Participant), Kuosmanen, S. (Participant), Laaksonen, T. (Participant), Leino, T. (Participant), Lindh, I. (Participant), Luukkonen, J. (Participant), McWilliams, T. (Participant), Norio, J. (Participant), Nur, N. H. M. (Participant), Näre, L. (Participant), Paavilainen, V. (Participant), Pajari, A.-M. (Participant), Pessi, A. B. (Participant), Pitkänen, E. (Participant), Rantamäki, T. (Participant), Repo, H. D. (Participant), Rubinacci, S. (Participant), STRATOULIAS, V. (Participant), Sandell, M. (Participant), Strachan, C. (Participant), Uimari, P. (Participant), Vattulainen, I. T. (Participant), Wohlström, T. (Participant), Wrede, S. (Participant) & Öörni, K. (Participant)
Academy of Finland, Suomen Akatemia Projektilaskutus, Suomen Akatemia Talous/Paula Pesola
01/01/2025 → 31/12/2030
Project: Research Council of Finland: Strengthening university research profiles (PROFI)
NIH Paavilainen / The Johns Hopkins Univ
Paavilainen, V. (Project manager), Collin, P. M. (Participant), Sipilä, T. J. O. (Participant), Venkatesha Murthy, A. (Participant) & Yuan, Y. (Participant)
Johns Hopkins University
17/09/2024 → 31/08/2027
Project: Other funder
Jusélius / Ville Paavilainen 2024-2027
Paavilainen, V. (Project manager), Kleemola, P. (Participant), Paatero, A. (Participant), Paudel, P. (Participant) & Venkatesha Murthy, A. (Participant)
Sigrid Juséliuksen Säätiö @003701165704@
01/05/2024 → 30/04/2026
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
NIH / Ville Paavilainen 2023-2027
Paavilainen, V. (Project manager), Paatero, A. (Participant) & Tranter, D. (Participant)
Oregon State University Department of Environmental & Molecular Toxicology
01/09/2023 → 31/07/2027
Project: Other funder

7 Member of doctoral thesis committee / follow-up group
5 Invited talk
3 Academic visit at UH
2 Organisation and participation in conferences, workshops, courses, seminars
More
- 1 Supervisor or co-supervisor of doctoral thesis
- 1 Supervision of other thesis (Master's, Licentiate)

Keynote Lecture at 1st Drug Discovery and Development Conference -Pakistan
Paavilainen, V. (Speaker)
3 Jan 2018
Activity: Talk or presentation types › Invited talk
Talk at EMBO Proteostasis Meeting -Ericeira, Portugal
Paavilainen, V. (Speaker)
30 Nov 2017
Activity: Talk or presentation types › Invited talk
Member of doctoral thesis committee Sudeep Karki
Paavilainen, V. (Supervisor)
2016
Activity: Examination types › Member of doctoral thesis committee / follow-up group
XXVII Paulo Foundation Symposium, Organelle communication in metabolism – from intracellular lipid fluxes to fatty liver
Paavilainen, V. (Attendee)
13 Jun 2016 → 15 Jun 2016
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Janet Iwasa
Paavilainen, V. (Host)
5 Sept 2016
Activity: Hosting a visitor types › Academic visit at UH

Finnish drug lead molecule shows promise in targeting the new coronavirus
Vapalahti, O. & Paavilainen, V.
15/07/2020
1 item of Media coverage
Press/Media: Press / Media
Ongoing research shows potential of anti-coronavirus drug
Paavilainen, V.
07/05/2020
1 item of Media coverage
Press/Media: Press / Media
-UNIVERSITY OF HELSINKI: A drug lead molecule studied by Viikki Biochemists may help in the fight against COVID-19
Vapalahti, O. & Paavilainen, V.
07/05/2020
1 item of Media coverage
Press/Media: Press / Media
A drug lead molecule studied by Viikki Biochemists may help in the fight against COVID-19
Vapalahti, O. & Paavilainen, V.
06/05/2020
1 item of Media coverage
Press/Media: Press / Media
Drug lead molecule may help to fight against coronavirus
Paavilainen, V.
06/05/2020
1 item of Media coverage
Press/Media: Press / Media

Ville Paavilainen

Personal profile

External positions

Fields of Science

Collaborations and top research areas from the last five years

Dive into details

Lipid Scrambling Pathways in the Sec61 Translocon Complex

Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity

Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells

Molecular view of ER membrane remodeling by the Sec61/TRAP translocon

Signal peptide mimicry primes Sec61 for client-selective inhibition

EU HE RIA VIGILANT / Paavilainen Ville

Yliopiston profilointi 8 - DIVSOL - Humt

NIH Paavilainen / The Johns Hopkins Univ

Jusélius / Ville Paavilainen 2024-2027

NIH / Ville Paavilainen 2023-2027

Keynote Lecture at 1st Drug Discovery and Development Conference -Pakistan

Talk at EMBO Proteostasis Meeting -Ericeira, Portugal

Member of doctoral thesis committee Sudeep Karki

XXVII Paulo Foundation Symposium, Organelle communication in metabolism – from intracellular lipid fluxes to fatty liver

Janet Iwasa

Finnish drug lead molecule shows promise in targeting the new coronavirus

Ongoing research shows potential of anti-coronavirus drug

-UNIVERSITY OF HELSINKI: A drug lead molecule studied by Viikki Biochemists may help in the fight against COVID-19

A drug lead molecule studied by Viikki Biochemists may help in the fight against COVID-19

Drug lead molecule may help to fight against coronavirus

Ville Paavilainen

Personal profile

External positions

Fields of Science

Collaborations and top research areas from the last five years

Research output

Projects

Activities

Press/Media