Photo of Virpi Talman
  • PL 56 (Viikinkaari 5)

    00014

    Finland

20042024
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Publications 2004 2019

  • 20 Article
  • 5 Meeting Abstract
  • 4 Review Article
  • 1 Doctoral Thesis
2019

A potent partial agonist of PKC orients in membranes like the biological activator diacylglycerol

Lautala, S., Koivuniemi, A., Kulig, W., Rog, T., Talman, V., Tuominen, R. & Bunker, A., Jul 2019, In : European Biophysics Journal. 48, p. S122-S122 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access
File

Cardiomyocyte—Endothelial Cell Interactions in Cardiac Remodeling and Regeneration

Talman, V. & Kivelä, M. R., 26 Jul 2018, In : Frontiers in cardiovascular medicine. 2018 / 5, 8 p., 101.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Combined transcriptomics, proteomics and metabolomics analysis identifies metabolic pathways associated with the loss of cardiac regeneration

Talman, V., Teppo, J., Poho, P., Movahedi, P., Vaikkinen, A., Pahikkala, T., Kotiaho, T., Kostiainen, R., Varjosalo, M. & Ruskoaho, H., Apr 2018, In : Cardiovascular Research. 114, p. S22-S23 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access
File

Dual‐drug delivery using dextran‐functionalized nanoparticles targeting cardiac fibroblasts for cellular reprogramming

Ferreira, M. P. A., Talman, V., Torrieri, G., Liu, D., Marques, G., Moslova, K., Liu, Z., Pinto, J. F., Hirvonen, J., Ruskoaho, H. & Santos, H. A., 11 Apr 2018, In : Advanced Functional Materials. 28, 15, 12 p., 1705134.

Research output: Contribution to journalArticleScientificpeer-review

Identification of cardiomyocyte-specific lncRNAs as potential regulators of cardiac regeneration

Pohjolainen, L., Kinnunen, S., Ruskoaho, H. & Talman, V., Apr 2018, In : Cardiovascular Research. 114, p. S1-S1 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

Molecular Atlas of Postnatal Mouse Heart Development

Talman, V., Teppo, J. S., Pöhö, P. A., Movahedi, P., Vaikkinen, A., Karhu, S. T., Trošt, K., Suvitaival, T., Heikkonen, J., Pahikkala, T., Kotiaho, A. A. T., Kostiainen, R. K., Varjosalo, M. T. & Ruskoaho, H. J., 16 Oct 2018, In : Journal of the American Heart Association. 7, 20, 46 p., 010378.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Protein kinase C-activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

Sarajärvi, T., Jäntti, M., Paldanius, K. M. A., Natunen, T., Wu, J. C., Mäkinen, P., Tarvainen, I., Tuominen, R. K., Talman, V. & Hiltunen, M., Oct 2018, In : Neuropharmacology. 141, p. 76-88 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

Välimäki, M. J., Tölli, M. A., Kinnunen, S. M., Aro, J., Serpi, R., Pohjolainen, L., Talman, V., Poso, A. & Ruskoaho, H. J., 28 Sep 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7781-7798 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Drug-loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

Ferreira, M. P. A., Ranjan, S., Kinnunen, S., Correia, A., Talman, V., Mäkilä, E., Barrios-Lopez, B., Kemell, M., Balasubramanian, V., Salonen, J., Hirvonen, J., Ruskoaho, H., Airaksinen, A. J. & Santos, H. A., 6 Sep 2017, In : Small. 13, 33, 14 p., 1701276.

Research output: Contribution to journalArticleScientificpeer-review

2016

Cardiac fibrosis in myocardial infarction - from repair and remodeling to regeneration

Talman, V. & Ruskoaho, H. J., 1 Sep 2016, In : Cell and Tissue Research. 365, 3, p. 563-581 19 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?

Talman, V., Pascale, A., Jäntti, M., Amadio, M. & Tuominen, R. K., Aug 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 2, p. 149-160 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
2015

Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

Rossi, D., Talman, V., Boije af Gennäs, G., Marra, A., Picconi, P., Nasti, R., Serra, M., Ann, J., Amadio, M., Pascale, A., Tuominen, R. K., Yli-Kauhaluoma, J., Lee, J. & Collina, S., 2015, In : MedChemComm. 6, 4, p. 547-554 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3

Talman, V., Gateva, G., Ahti, M., Ekokoski, E., Lappalainen, P. & Tuominen, R. K., 2014, In : European Journal of Pharmaceutical Sciences. 55, p. 46-57 12 p.

Research output: Contribution to journalArticleScientificpeer-review

File

Lääkekehityksen alkumetreillä: kohteena proteiinikinaasi C:n C1 osa

Talman, V., 2014, In : Farmasia : Suomen farmasialiiton jäsenlehti. 2014, 1, p. 44-46 3 p.

Research output: Contribution to journalArticleProfessional

2013

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

Talman, V., Amadio, M., Osera, C., Sorvari, S., Boije af Gennäs, G., Yli-Kauhaluoma, J., Rossi, D., Govoni, S., Collina, S., Ekokoski, E., Tuominen, R. K. & Pascale, A., 2013, In : Pharmacological Research. 73, p. 44-54 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

Talman, V., Tuominen, R. K., Boije af Gennäs, G., Yli-Kauhaluoma, J. & Ekokoski, E., 2011, In : PLoS One. 6, 5, p. e20053 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Current Status and Future Prospects of C1 Domain Ligands as Drug Candidates

Boije af Gennäs, G., Talman, V., Yli-Kauhaluoma, J., Tuominen, R. K. & Ekokoski, E., 2011, In : Current Topics in Medicinal Chemistry. 11, 11, p. 1370-1392 23 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Stereoselective synthesis of (3-aminodecahydro-1,4-methanonaphthalen-2-yl) methanols targeted to the C1 domain of protein kinase C

Kiriazis, A., Boije af Gennäs, G., Talman, V., Ekokoski, E., Ruotsalainen, T., Kylänlahti, I., Rüffer, T., Wissel, G., Xhaard, H., Lang, H., Tuominen, R. K. & Yli-Kauhaluoma, J., 11 Nov 2011, In : Tetrahedron. 67, 45, p. 8665-8670 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C

Boije af Gennäs, G., Talman, V., Aitio, O., Ekokoski, E., Finel, M., Tuominen, R. K. & Yli-Kauhaluoma, J., 2009, In : Journal of Medicinal Chemistry. 52, 13, p. 3969-3981 13 p.

Research output: Contribution to journalArticleScientificpeer-review

File
2005

Nivelreuman hoidossa monia mullistuksia

Talman, V., 2005, In : Suomen apteekkarilehti. 2005, 5, p. 28-29 2 p.

Research output: Contribution to journalArticleProfessional

2004

Screening of natural compounds and their derivatives as potential protein kinase C inhibitors

Tammela, P., Ekokoski, E., Garcia Horsman, J. A., Talman, V., Finel, M., Tuominen, R. & Vuorela, P., 2004, In : Drug Development Research. 63, 2, p. 76-87 12 p.

Research output: Contribution to journalArticleScientificpeer-review