Research output per year
Research output per year
Personal profile
External positions
Academy postdoctoral researcher, Tampere University of Technology
1 Jan 2013 → 31 Aug 2016
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- Computational biology
- Computational Chemistry
- Computational drug design
- 119 Other natural sciences
- Molecular dynamics simulations
- Quantum Chemistry
- Hybrid QM/MM MD simulations
- Mitochondrial proteins
- Redox coupled proton pumping
- Mitochondrial dysfunction
International and National Collaboration
Publications and projects within past five years.
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On the role of ubiquinone in the proton translocation mechanism of respiratory complex I
Wikström, M., Djurabekova, A. & Sharma, V., Jan 2023, In: FEBS Letters. 597, 2, p. 224-236 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Structural basis of mitochondrial membrane bending by the I-II-III2-IV2 supercomplex
Mühleip, A., Flygaard, R. K., Baradaran, R., Haapanen, O., Gruhl, T., Tobiasson, V., Maréchal, A., Sharma, V. & Amunts, A., 30 Mar 2023, In: Nature. 615, 7954, p. 934–938 23 p.Research output: Contribution to journal › Article › Scientific
Open AccessFile -
Tunnel dynamics of quinone derivatives and its coupling to protein conformational rearrangements in respiratory complex I
Lasham, J., Haapanen, O., Zickermann, V. & Sharma, V., Apr 2023, In: Biochimica et Biophysica Acta. Bioenergetics. 1864, 2, 9 p., 148951.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
(S2.P4) Mechanistic insights on sodium and proton transfer pathways from molecular dynamics simulations of Mrp-type antiporter
Haapanen, O., Lee, Y., Altmeyer, A., Kühlbrandt, W., Zickermann, V. & Sharma, V., Sep 2022, In: Biochimica et Biophysica Acta. Bioenergetics. 1863, p. 15-16 5 p., 148644.Research output: Contribution to journal › Meeting Abstract
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(S3.P1) Oxidised states of cytochrome c oxidase
Sharma, V. & Wikström, M., Sep 2022, In: Biochimica et Biophysica Acta. Bioenergetics. 1863, p. 24-24 1 p., 148671.Research output: Contribution to journal › Meeting Abstract
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Molecular basis of oncogenic mutations
Syöpäsäätiö sr Cancerstiftelsen sr
01/01/2023 → 31/12/2025
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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Molecular mechanisms of mitochondrial enzymes, and their role in health and diseases
Sharma, V., Djurabekova, A., Haapanen, O., Malkamäki, A., Lasham, J., Reidelbach, M., Chiarini, V. & Nyman, A. I.
01/01/2018 → 31/12/2021
Project: University of Helsinki Three-Year Research Project
Datasets
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Snapshots from MD simulations of bacterial and mitochondrial complex I
Sharma, V. (Creator), Zenodo, 2018
Dataset
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Simulation snapshots of complex I molecular dynamics simulation
Sharma, V. (Creator), Zenodo, 2017
DOI: https://doi.org/10.5281/zenodo.267916
Dataset
Activities
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A truly long range e-/H+ coupling in respiratory complex I - MD simulations of quinone chamber and antiporter-like subunits
Vivek Sharma (Speaker)
2022 → …Activity: Talk or presentation types › Invited talk
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Biochimica et Biophysica Acta. Bioenergetics (Journal)
Vivek Sharma (Reviewer)
2022Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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Nature Communications (Journal)
Vivek Sharma (Reviewer)
2022Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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Quinone Binding and Dynamics in Respiratory Complex I
Vivek Sharma (Supervisor)
2022Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
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Frontiers in Chemistry (Journal)
Vivek Sharma (Reviewer)
2022Activity: Publication peer-review and editorial work types › Editor of series
Press/Media
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Atomistic insights into the structure of mitochondrial complex I
23/11/2021
1 Media contribution
Press/Media: Press / Media
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Researchers discovered an important role for hydrogen bonding in mitochondrial disease mutation
30/08/2021
1 Media contribution
Press/Media: Press / Media
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Structural biology, biochemistry and molecular simulations of mitochondrial complex I – a key role of accessory protein in biological energy conversion
02/12/2020
1 item of Media coverage
Press/Media: Press / Media
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Researchers find that accessory subunit plays a key role in biological energy conversion by mitochondrial complex I
02/12/2020
1 Media contribution
Press/Media: Press / Media
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Mechanism of signal transmission in blood cell development deciphered
07/02/2020
1 item of Media coverage
Press/Media: Press / Media