Research output per year
Research output per year
Personal profile
External positions
Academy postdoctoral researcher, Tampere University of Technology
1 Jan 2013 → 31 Aug 2016
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- Computational biology
- Computational Chemistry
- Computational drug design
- 119 Other natural sciences
- Molecular dynamics simulations
- Quantum Chemistry
- Hybrid QM/MM MD simulations
- Mitochondrial proteins
- Redox coupled proton pumping
- Mitochondrial dysfunction
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Assessment of amino acid charge states based on cryo-electron microscopy and molecular dynamics simulations of respiratory complex I
Lasham, J., Djurabekova, A., Kolypetris, G., Zickermann, V., Vonck, J. & Sharma, V., 1 Jan 2025, In: Biochimica et Biophysica Acta - Bioenergetics. 1866, 1, 8 p., 149512.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Conformational dynamics of a histidine molecular switch in a cation/proton antiporter
Pecorilla, C., Altmeyer, A., Haapanen, O., Lee, Y., Zickermann, V. & Sharma, V., 1 Nov 2025, In: Biochimica et Biophysica Acta. Bioenergetics. 1866, 4, 14 p., 149563.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Dynamic binding of acetogenin-type inhibitors to mitochondrial complex I revealed by photoaffinity labeling
Nishida, M., Pecorilla, C., Masuya, T., Hirano, K., Abe, M., Zdorevskyi, O., Sharma, V., Miyoshi, H. & Murai, M., 1 Nov 2025, In: Biochimica et Biophysica Acta - Bioenergetics. 1866, 4, 11 p., 149566.Research output: Contribution to journal › Article › Scientific › peer-review
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Proton Transfer through a Charged Conduit in Respiratory Complex I: Long-Range Effects and Conformational Gating
Zdorevskyi, O. & Sharma, V., 18 Sept 2025, In: Journal of Chemical Information and Modeling. 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Analysis of the Atomistic MD Simulations of CI+CIII2 Interactions and Associated Lipid Binding
Djurabekova, A., Shin, Y.-C., Latorre-Muro, P., Zdorevskyi, O., Bennett, C. F., Burger, N., Song, K., Xu, C., Liao, M., Puigserver, P. & Sharma, V., 1 Sept 2024, In: Biochimica et Biophysica Acta. Bioenergetics. 1865, Supplement, p. 56-57 2 p., 149253.Research output: Contribution to journal › Meeting Abstract
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Sharma JAES 2025-2028
Sharma, V. (Project manager), Endres, E. A. (Participant), Jousmäki, M. A. I. (Participant), Laukkanen, J. O. A. (Participant) & Pecorilla, C. (Participant)
01/05/2025 → 30/04/2028
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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Computer simulation and cryo EM modeling
Sharma, V. (Project manager), Kolypetris, G. (Participant) & Torabi, M. (Participant)
Suomen Tiedeseura r.y. Finska Vetenskaps-Societeten r.f.
01/04/2025 → 30/04/2026
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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Jusélius/Sharma 2024
Sharma, V. (Project manager), Abettan, A. (Participant), Jousmäki, M. A. I. (Participant), Kolypetris, G. (Participant) & Laukkanen, J. O. A. (Participant)
Sigrid Juséliuksen Säätiö @003701165704@
01/05/2024 → 30/04/2026
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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Molecular basis of oncogenic mutations
Goldman, A. (Project manager), Sharma, V. (Project manager), Haapanen, O. (Participant) & de Castro Ribeiro, O. M. (Participant)
Syöpäsäätiö sr Cancerstiftelsen sr
01/01/2023 → 31/12/2025
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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Molecular mechanisms of mitochondrial enzymes, and their role in health and diseases
Sharma, V. (Project manager), Djurabekova, A. (Participant), Haapanen, O. (Participant), Malkamäki, A. (Participant), Lasham, J. (Participant), Reidelbach, M. (Participant), Chiarini, V. (Participant) & Nyman, A. I. (Participant)
01/01/2018 → 31/12/2021
Project: University of Helsinki Three-Year Research Project
Datasets
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Snapshots from MD simulations of Yarrowia lipolytica complex I
Sharma, V. (Creator) & Lasham, J. (Creator), Zenodo, 2023
Dataset
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Snapshots from MD simulations of Yarrowia lipolytica complex I with 2Qs
Sharma, V. (Creator) & Djurabekova, A. (Creator), Zenodo, 2023
Dataset
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Snapshots from MD simulations of bacterial and mitochondrial complex I
Sharma, V. (Creator), Zenodo, 2018
Dataset
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Simulation snapshots of complex I molecular dynamics simulation
Sharma, V. (Creator), Zenodo, 2017
DOI: https://doi.org/10.5281/zenodo.267916
Dataset
Activities
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3rd Kumpula-Viikki collaboration "Open doors day"
Sharma, V. (Member of organizing committee)
2024Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Probing the long-range coupling mechanism of respiratory complex I by multiscale computational modeling
Sharma, V. (Supervisor)
2024Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
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COMPUTATIONAL EXPLORATION OF OATP SUBSTRATE BINDING AND TRANSPORT DYNAMICS
Sharma, V. (Pre-examiner)
2024Activity: Examination types › Pre-examiner of doctoral thesis
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Max Planck Society (External organisation)
Sharma, V. (Assessment)
2024Activity: Membership types › Assessment of candidates for academic posts
Press/Media
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How cold adaptation works in brown adipose tissue?
22/10/2024
1 Media contribution
Press/Media: Press / Media
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Membrane shaping by a large bioenergetic complex for functional specialization
27/03/2023
1 Media contribution
Press/Media: Press / Media
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Atomistic insights into the structure of mitochondrial complex I
23/11/2021
1 Media contribution
Press/Media: Press / Media
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Researchers discovered an important role for hydrogen bonding in mitochondrial disease mutation
30/08/2021
1 Media contribution
Press/Media: Press / Media
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Researchers find that accessory subunit plays a key role in biological energy conversion by mitochondrial complex I
02/12/2020
1 Media contribution
Press/Media: Press / Media