If you made any changes in Pure these will be visible here soon.

Personal profile

Description of research and teaching

Key research interests

Tissue engineering for drug research

My research focuses on developing functional and predictive cell-based tools for drug research and personalized medicine. We use stem cells- and biomaterials-based tissue engineering approach to produce functional cells and tissues. We have developed flexible, dynamic three-dimensional (3D) culture systems for human pluripotent stem cells (human embryonic stem cells and induced pluripotent stem cells) and human cancer cells. The current specific objective is to generate functional hepatocytes with 3D configuration as drug development tools for drug and chemical testing. We apply advanced cell culture technologies and novel biomaterials, along with molecular biology methods. Our research not only develops new cell-based technologies but also advance fundamental understanding of how matrix and biomaterials affect cell behavior and performance.

https://scholar.google.fi/citations?user=ZrW2FTsAAAAJ&hl=en&oi=ao

Teaching

Cell-biomaterials interactions, pharmaceutical and medical applications (lecture course 590284, 3 credits)

In vitro drug permeability (Advanced biopharmaceutics practicals 590289)

Curriculum vitae

Short curriculum vitae

Education

BSc in Pharmacy, School of Pharmacy, West China University of Medical Sciences, Chengdu, China, 1996

PhD in Molecular Endocrinology, Faculty of Medicine, University of Tampere, Finland, 2005

Academic posts

Pharmacist, Institute for Drug Control, Xi'An, China, 1996-1999

Researcher, University of Tampere, Tampere, Finland, 1999-2006

Senior researcher, REGEA Institute for Regenerative Medicine, Tampere, Finland, 2006-2007

Research scientist, A*STAR Institute of Bioengineering and Nanotechnology (IBN), Singapore, 2007-2009

Principal investigator, University of Helsinki, Helsinki, Finland, 2009-

 

Education/Academic qualification

Biopharmaceutics, Adjunct Professor, University of Helsinki

Keywords

  • 317 Pharmacy
  • 314 Health sciences
  • Molecular endocrinology
  • Cancer biology
  • 311 Basic medicine
  • Stem cell biology
  • 1182 Biochemistry, cell and molecular biology
  • Cell and molecular biology

International and National Collaboration Publications and projects within past five years.

Publications 2001 2019

Quantified forces between HepG2 hepatocarcinoma and WA07 pluripotent stem cells with natural biomaterials correlate with in vitro cell behavior

Harjumaki, R., Nugroho, R. W. N., Zhang, X., Lou, Y-R., Yliperttula, M., Valle-Delgado, J. J. & Österberg, M., 14 May 2019, In : Scientific Reports. 9, 14 p., 7354.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Quantifying the interactions between biomimetic biomaterials - collagen I, collagen IV, laminin 521 and cellulose nanofibrils - by colloidal probe microscopy

Nugroho, R. W. N., Harjumäki, R., Zhang, X., Lou, Y-R., Yliperttula, M., Valle-Delgado, J. J. & Österberg, M., 1 Jan 2019, In : Colloids and Surfaces B: Biointerfaces. 173, p. 571-580 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals

Smutný, T., Harjumäki, R., Kanninen, L., Yliperttula, M. L., Pávek, P. & Lou, Y-R., Oct 2018, In : Toxicology in Vitro. 52, p. 94-105 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Differences in definitive endoderm induction approaches using growth factors and small molecules

Bogacheva, M. S., Khan, S., Kanninen, L. K., Yliperttula, M., Leung, A. W. & Lou, Y-R., Apr 2018, In : Journal of Cellular Physiology. 233, 4, p. 3578-3589 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Next generation organoids for biomedical research and applications

Lou, Y-R. & Leung, A. W., 2018, In : Biotechnology Advances. 36, 1, p. 132-149 18 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Projects 2008 2019

EDUFI-Fellowship / Bystriakova

Lou, Y. & Bystriakova, M.

01/01/201930/09/2019

Project: Research project

Stem cell-derived, three-dimensional liver: the missing link in drug discovery

Lou, Y., Harjumäki, R., Kanninen, L., Smutný, T., Bogacheva, M., Salmi, T., Makhdoom, Y. & Taalas, A. P.

SUOMEN AKATEMIA

02/09/201531/12/2016

Project: Research project

CIMO Fellowship / Bogacheva

Lou, Y. & Bogacheva, M.

08/04/201530/04/2016

Project: Research project

Activities 2004 2017

Bioscience Reports (Journal)

Yan-Ru Lou (Reviewer)
May 2017

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Scientific Reports (Journal)

Yan-Ru Lou (Member of editorial board)
Jan 2017 → …

Activity: Publication peer-review and editorial work typesEditor of research journal

keynote speaker

Yan-Ru Lou (Keynote speaker)
28 Sep 201729 Sep 2017

Activity: Talk or presentation typesInvited talk

Scientific Reports (Journal)

Yan-Ru Lou (Reviewer)
Jun 2017

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Journal of Cellular and Molecular Medicine (Journal)

Yan-Ru Lou (Reviewer)
Jan 2017

Activity: Publication peer-review and editorial work typesPeer review of manuscripts