A Drug Nanocrystal-Encapsulated Nanovector Toward Targeted Cancer Theranostics

Project Details

Description

This highly interdisciplinary project aims to develop an optimal nano-in-nano vector for cancer targeted theranostics. The proposed nanovector merges the favorable features of calcium phosphate nanoparticles, such as biocompatibility, biodegradability and pH-responsive release of payloads, those of drug nanocrystals including the ultrahigh drug loading degree and enhanced dissolution rate, and contrast agent nanoparticles for non-invasive imaging of tumor malignancy. Overall, this theranostic nanovector is expected to simultaneously boost contrast agents relaxivity when the contrast agent is discharged from the disintegrative calcium phosphate shell, and to kill the cancer cells when ultrahigh mass fraction of therapeutics is released, in response to the intratumoral pH.
StatusFinished
Effective start/end date01/09/201731/08/2020

Funding

  • SUOMEN AKATEMIA: €279,990.00

Fields of Science

  • 317 Pharmacy
  • Drug delivery
  • nanoparticles
  • theranostics
  • ultrahigh drug loading
  • 216 Materials engineering
  • microfluidics
  • sequential nanoprecipitation

Projects

Research Output

Chapter 7 - Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems

Zhang, Y., Liu, D., Zhang, H. & Almeida Santos, H., 2019, Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery. Santos, H. A., Liu, D. & Zhang, H. (eds.). 1st ed. San Diego: Elsevier, p. 155-177 23 p. (Micro and Nano Technologies).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Liu, Z., Li, Y., Li, W., Lian, W., Kemell, M., Hietala, S., Figueiredo, P., Li, L., Mäkilä, E., Ma, M., Salonen, J., Hirvonen, J. T., Liu, D., Zhang, H., Deng, X. & Santos, H. A., 1 Feb 2019, In : Materials Horizons. 6, 2, p. 385-393 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery

Almeida Santos, H. (ed.), Liu, D. (ed.) & Zhang, H. (ed.), 2019, 1st ed. Amsterdam: Elsevier Scientific Publ. Co. 495 p. ( Micro & nano technologies)

Research output: Book/ReportAnthology or special issueScientificpeer-review