Projects per year
Project Details
Description (abstract)
BACKGROUND
Cerebral small vessel disease (SVD) is a major health problem, with estimated 250,000 persons in Finland with severe white matter changes. Our first research project aims to find tools for future intervention studies in order to prevent and treat small vessel disease. By improving the function of the small vessels and thus avoiding vascular exacerbations, the clinical manifestations of neurodegenerative illnesses can be postponed, such as Alzheimer´s disease.
CURRENT STAGE AND RESULTS
At the moment we are recruiting and examining a hospital-based cohort of 200 patients with white matter changes ranging from Fazekas 0 to 3. The patients will undergo advanced brain imaging with resting state fMRI, multicontrast-MRI and tractography. In addition to clinical neurological examination, the patients are examined by neuropsychologist. We also analyze cerebrospinal fluid from a subgroup. Development of MRI protocols and pipelines for the new imaging methods has been an important part of the project.
AIMS OF THE RESEARCH
The SVD study is preparation for an intervention study, giving tools for detecting subtle changes in small vessels in an earlier phase than before.
Cerebral small vessel disease (SVD) is a major health problem, with estimated 250,000 persons in Finland with severe white matter changes. Our first research project aims to find tools for future intervention studies in order to prevent and treat small vessel disease. By improving the function of the small vessels and thus avoiding vascular exacerbations, the clinical manifestations of neurodegenerative illnesses can be postponed, such as Alzheimer´s disease.
CURRENT STAGE AND RESULTS
At the moment we are recruiting and examining a hospital-based cohort of 200 patients with white matter changes ranging from Fazekas 0 to 3. The patients will undergo advanced brain imaging with resting state fMRI, multicontrast-MRI and tractography. In addition to clinical neurological examination, the patients are examined by neuropsychologist. We also analyze cerebrospinal fluid from a subgroup. Development of MRI protocols and pipelines for the new imaging methods has been an important part of the project.
AIMS OF THE RESEARCH
The SVD study is preparation for an intervention study, giving tools for detecting subtle changes in small vessels in an earlier phase than before.
Status | Active |
---|---|
Effective start/end date | 01/01/2016 → 31/08/2025 |
Fields of Science
- 3124 Neurology and psychiatry
- 515 Psychology
Projects
- 2 Active
-
Cognitive impairment in cerebral small vessel disease: Early signs and determinants of progression
Jokinen, H. (Participant)
01/09/2022 → 31/08/2026
Project: Research Council of Finland: Clinical Researcher
-
Cognitive impairment in cerebral small vessel disease: Early signs and determinants of progression
Jokinen, H. (Project manager)
01/09/2022 → 30/08/2026
Project: Research Council of Finland: Clinical Researcher
-
Executive functions and processing speed in covert cerebral small vessel disease
Jokinen, H., Laakso, H. M., Arola, A., Paajanen, T., Virkkala , J., Särkämö, T., Makkonen, T., Kyläheiko, I. S., Heinonen, H., Pitkänen, J., Korvenoja, A. & Melkas, S., 2025, In: European Journal of Neurology. 32, 1, 9 p., e16533.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
European Stroke Organisation (ESO) Guideline on Cerebral Small Vessel Disease, Part 2, Lacunar Ischaemic Stroke
Wardlaw, J. M., Chabriat, H., de Leeuw, F.-E., Debette, S., Dichgans, M., Doubal, F., Jokinen, H., Katsanos, A., Ornello, R., Pantoni, L., Pasi, M., Pavlovic, A. M., Rudilosso, S., Schmidt, R., Staals, J., Taylor-Rowan, M., Hussain, S. & Lindgren, A. G., Mar 2024, In: European Stroke Journal. 9, 1, p. 5-68 64 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
In memoriam, Timo Juha Erkinjuntti, MD PhD, Professor in Neurology, University of Helsinki, Finland
Pantoni, L., Jokinen, H., Melkas, S. & Kalaria, R., 30 Aug 2024, In: Cerebral circulation, cognition and behavior. 7, 3 p., 100365.Research output: Contribution to journal › Article › Scientific
Open AccessFile
-
Determinants and early identification of cognitive and neuropsychiatric symptoms in cerebral small vessel disease
Jokinen, H. (Speaker)
10 Oct 2024Activity: Talk or presentation types › Invited talk
-
20th European Angiology Days: Cognitive and neuropsychiatric symptoms in covert cerebral small vessel disease
Jokinen, H. (Invited speaker)
1 Dec 2023Activity: Talk or presentation types › Invited talk
-
Supervisor of doctoral dissertation: Anne Arola
Jokinen, H. (Supervisor)
2019 → …Activity: Examination types › Supervisor or co-supervisor of doctoral thesis