Projects per year
Project Details
Layman's description
Cerebrovascular diseases and particularly cerebral small vessel disease are common causes of cognitive impairment and progressive neurocognitive disorders. Previous research has focused on dementia as the end-state of the disease, while the early mechanisms of cognitive impairment are not well known. The aim of this study is to extend scientific knowledge on risk factors, diagnostic tools and determinants of progressive brain changes, cognitive impairment and behavioral symptoms as well as protective factors related to functional impairment in small vessel disease. The investigations will be carried out at the Helsinki University Hospital and University of Helsinki as part of two longitudinal studies, which both include extensive neuropsychological and clinical evaluations, and magnetic resonance imaging of the brain. The project will leverage digitalized neuropsychological tests and novel image analysis methods that enable more accurate quantification of brain changes than before.
Status | Active |
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Effective start/end date | 01/09/2022 → 31/08/2025 |
Fields of Science
- 515 Psychology
- 3124 Neurology and psychiatry
Projects
- 1 Active
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Cerebral small vessel disease - preparing for RCT
Melkas, S., Erkinjuntti, T. J., Jokinen, H., Laakso, H., Pitkänen, J., Arola, A. M., Korvenoja, A., Vanni, S., Ruuth, R., Lempiäinen, J. & Kartau, M.
01/01/2016 → 31/08/2025
Project: Research project
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Neuropsychiatric symptoms are associated with exacerbated cognitive impairment in covert cerebral small vessel disease
Arola, A., Levänen, T., Laakso, H. M., Pitkänen, J., Koikkalainen, J., Lötjönen, J., Korvenoja, A., Erkinjuntti, T., Melkas, S. & Jokinen, H., 30 Aug 2022, (E-pub ahead of print) In: Journal of the International Neuropsychological Society. 8 p., 1355617722000480.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
Synergistic associations of cognitive and motor impairments with functional outcome in covert cerebral small vessel disease
Jokinen, H., Laakso, H. M., Ahlström, M., Arola, A., Lempiäinen, J., Pitkänen, J., Paajnen, T., Sikkes, S. A. M., Koikkalainen, J., Lötjönen, J., Korvenoja, A., Erkinjuntti, T. & Melkas, S., Jan 2022, In: European Journal of Neurology. 29, 1, p. 158-167 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Associations of cognitive reserve and psychological resilience with cognitive functioning in subjects with cerebral white matter hyperintensities
Arola, A., Laakso, H. M., Pitkänen, J., Koikkalainen, J., Lötjönen, J., Korvenoja, A., Erkinjuntti, T., Melkas, S. & Jokinen, H., Aug 2021, In: European Journal of Neurology. 28, 8, p. 2622-2630 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile