Discovery and therapeutic exploitation of immunological vulnerabilities in ovarian cancer

Research output

Research output per year 2021 2021 2023

• 18 Article
• 1 Editorial
• 1 Review Article

Research output per year

Research output per year

Search results

• 2023

  Dysregulated germinal centre reaction with expanded T follicular helper cells in APECED lymph nodes

  Hetemäki, I., Sarkkinen, J., Heikkilä, N., Drechsel, K., Mäyränpää, M. I., Färkkilä, A., Laakso, S., Mäkitie, O., Arstila, T. P. & Kekäläinen, E., 19 Dec 2023, In: Journal of Allergy and Clinical Immunology. 153, 5, p. 1445-1455 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

  Pikkusaari, S., Tumiati, M., Virtanen, A., Oikkonen, J., Li, Y., Perez-Villatoro, F., Muranen, T., Salko, M., Huhtinen, K., Kanerva, A., Koskela, H., Tapper, J., Koivisto-Korander, R., Joutsiniemi, T., Haltia, U-M., Lassus, H., Hautaniemi, S., Färkkilä, A., Hynninen, J., Hietanen, S., & 2 othersCarpen, O. & Kauppi, L., 15 Aug 2023, In: Clinical Cancer Research. 29, 16, p. 3110-3123 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer

  Ding, L., Wang, Q., Martincuks, A., Kearns, M. J., Jiang, T., Lin, Z., Cheng, X., Qian, C., Xie, S., Kim, H-J., Launonen, I-M., Färkkilä, A., Roberts, T. M., Freeman, G. J., Liu, J. F., Konstantinopoulos, P. A., Matulonis, U., Yu, H. & Zhao, J. J., Jan 2023, In: Journal for Immunotherapy of Cancer. 11, 1, 15 p., e005627.

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• The Emerging Role of the Single-Cell and Spatial Tumor Microenvironment in High-Grade Serous Ovarian Cancer

  Launonen, I-M., Vähärautio, A. & Färkkilä, A., Oct 2023, In: Cold Spring Harbor Perspectives in Medicine. 13, 10, 9 p., a041314.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Uusi työkalu räätälöityyn munasarjasyövän hoitoon

  Translated title of the contribution: Functional homologous recombination assay on FFPE specimens of advanced high-grade serous ovarian cancer predicts clinical outcomesPikkusaari, S., Tumiati, M., Virtanen, A., Oikkonen, J., Li, Y., Perez-Villatoro, F., Muranen, T., Salko, M., Huhtinen, K., Kanerva, A., Koskela, H., Tapper, J., Koivisto-Korander, R., Joutsiniemi, T., Haltia, U-M., Lassus, H., Hautaniemi, S., Färkkilä, A., Hynninen, J., Hietanen, S., & 2 othersCarpen, O. & Kauppi, L., 15 Aug 2023, In: Duodecim. 139, 9, p. 760 1 p.

  Research output: Contribution to journal › Article › Professional

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• 2022

  Analysis of Non-Relapsed and Relapsed Adult Type Granulosa Cell Tumors Suggests Stable Transcriptomes during Tumor Progression

  Andersson, N., Haltia, U-M., Färkkilä, A., Wong, S. C., Eloranta, K., Wilson, D. B., Unkila-Kallio, L., Pihlajoki, M., Kyrönlahti, A. & Heikinheimo, M., Feb 2022, In: Current Issues in Molecular Biology. 44, 2, p. 686-698 13 p.

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• Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer

  Perez Villatoro, F. R., Oikkonen, J., Casado, J., Chernenko, A., Gulhan, D. C., Tumiati, M., Li, Y., Lavikka, K. A., Hietanen, S., Hynninen, J., Haltia, U-M., Tyrmi, J. S., Laivuori, H., Konstantinopoulos, P. A., Hautaniemi, S., Kauppi, L. & Färkkilä, A., 2022, In: npj precision oncology. 6, 1, 13 p., 96.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer

  Launonen, I-M., Lyytikäinen, N., Casado, J., Anttila, E. A., Szabo, A., Haltia, U-M., Jacobson, C. A., Lin, J. R., Maliga, Z., Howitt, B. E., Strickland, K. C., Santagata, S., Elias, K., D'Andrea, A. D., Konstantinopoulos, P. A., Sorger, P. K. & Färkkilä, A., Dec 2022, In: Nature Communications. 13, 1, 14 p., 835.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer

  Chae, C. S., Sandoval, T. A., Hwang, S. M., Park, E. S., Giovanelli, P., Awasthi, D., Salvagno, C., Emmanuelli, A., Tan, C., Chaudhary, V., Casado, J., Kossenkov, A. V., Song, M., Barrat, F. J., Holcomb, K., Romero-Sandoval, E. A., Zamarin, D., Pépin, D., D’andrea, A. D., Färkkilä, A., & 1 othersCubillos-Ruiz, J. R., 1 Aug 2022, In: Cancer Discovery. 12, 8, p. 1904-1921 18 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2021

  Adult-type granulosa cell tumor of the ovary: a FOXL2-centric disease

  Pilsworth, J. A., Cochrane, D. R., Neilson, S. J., Moussavi, B. H., Lai, D., Munzur, A. D., Senz, J., Wang, Y. K., Zareian, S., Bashashati, A., Wong, A., Keul, J., Staebler, A., van Meurs, H. S., Horlings, H. M., Kommoss, S., Kommoss, F., Oliva, E., Färkkilä, A. E. M., Gilks, B., & 1 othersHuntsman, D. G., May 2021, In: The Journal of Pathology. Clinical Research. 7, 3, p. 243-252 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Agile workflow for interactive analysis of mass cytometry data

  Casado, J., Lehtonen, O., Rantanen, V., Kaipio, K., Pasquini, L., Häkkinen, A., Petrucci, E., Hynninen, J., Hietanen, S., Carpen, O., Biffoni, M., Färkkilä, A. & Hautaniemi, S., 1 May 2021, In: Bioinformatics. 37, 9, p. 1263-1268 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer

  Konstantinopoulos, P. A., da Costa, A. A. B. A., Gulhan, D., Lee, E. K., Cheng, S-C., Hendrickson, A. E. W., Kochupurakkal, B., Kolin, D. L., Kohn, E. C., Liu, J. F., Stover, E. H., Curtis, J., Tayob, N., Polak, M., Chowdhury, D., Matulonis, U. A., Färkkilä, A., D'Andrea, A. D. & Shapiro, G., 22 Sept 2021, In: Nature Communications. 12, 1, 8 p., 5574.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• DNA-vaurioiden hyödyntäminen munasarjasyövän hoidossa

  Färkkilä, A., Launonen, I-M., Perez, F., Virtanen, A. & Lassus, H., 2021, In: Duodecim. 137, 21, p. 2287-2295 9 p.

  Research output: Contribution to journal › Review Article › peer-review

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• Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunothrapy

  Iyer, S., Zhang, S., Yucel, S., Horn, H., Smith, S. G., Reinhardt, F., Hoefsmit, E., Assatova, B., Casado, J., Meinsohn, M-C., Barrasa, M. I., Bell, G. W., Perez-Villatoro, F., Huhtinen, K., Hynninen, J., Oikkonen, J., Galhenage, P. M., Pathania, S., Hammond, P. T., Neel, B. G., & 3 othersFarkkila, A., Pepin, D. & Weinberg, R. A., Feb 2021, In: Cancer Discovery. 11, 2, p. 384-407 24 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells

  Färkkilä, A., Rodriguez, A., Oikkonen, J., Gulhan, D. C., Huy Nguyen, Dominguez, J., Ramos, S., Mills, C. E., Perez-Villatoro, F., Lazaro, J-B., Zhou, J., Clairmont, C. S., Moreau, L. A., Park, P. J., Sorger, P. K., Hautaniemi, S., Frias, S. & D'Andrea, A. D., 15 May 2021, In: Cancer Research. 81, 10, p. 2774-2787 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Inhibition of TGF beta 1 and TGF beta 3 promotes hematopoiesis in Fanconi anemia

  Rodriguez, A., Yang, C., Furutani, E., Teresa, B. G. D., Velazquez, M., Filiatrault, J., Sambel, L. A., Phan, T., Flores-Guzman, P., Sanchez, S., Orozco, A. M., Mayani, H., Bolukbasi, O. V., Färkkilä, A., Epperly, M., Greenberger, J., Shimamura, A., Frias, S., Grompe, M., Parmar, K., & 1 othersD'Andrea, A. D., Jan 2021, In: Experimental Hematology. 93, p. 70-U53 19 p.

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• MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

  Rodriguez, A., Zhang, K., Färkkilä, A., Filiatrault, J., Yang, C., Velazquez, M., Furutani, E., Goldman, D. C., Garcia de Teresa, B., Garza-Mayen, G., McQueen, K., Sambel, L. A., Molina, B., Torres, L., Gonzalez, M., Vadillo, E., Pelayo, R., Fleming, W. H., Grompe, M., Shimamura, A., & 5 othersHautaniemi, S., Greenberger, J., Frias, S., Parmar, K. & D'Andrea, A. D., 7 Jan 2021, In: Cell Stem Cell. 28, 1, p. 33-+ 23 p.

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• Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation

  Duraiswamy, J., Turrini, R., Minasyan, A., Barras, D., Crespo, I., Grimm, A. J., Casado, J., Genolet, R., Benedetti, F., Wicky, A., Ioannidou, K., Castro, W., Neal, C., Moriot, A., Renaud-Tissot, S., Anstett, V., Fahr, N., Tanyi, J. L., Eiva, M. A., Jacobson, C. A., & 16 othersMontone, K. T., Westergaard, M. C. W., Svane, I. M., Kandalaft, L. E., Delorenzi, M., Sorger, P. K., Färkkilä, A., Michielin, O., Zoete, V., Carmona, S. J., Foukas, P. G., Jr, D. J. P., Rusakiewicz, S., Doucey, M-A., Laniti, D. D. & Coukos, G., 13 Dec 2021, In: Cancer Cell. 39, 12, p. 1623-+ 41 p.

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• PARP:n estäjät mullistavat munasarjasyövän hoidon : hoidosta eniten hyötyvät voidaan tunnistaa geneettisen testauksen avulla

  Färkkilä, A., Lassus, H. & Loukovaara, M., 2021, In: Duodecim. 137, 21, p. 2228-2230 3 p.

  Research output: Contribution to journal › Editorial › Professional

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• Procaspase-Activating Compound-1 Synergizes with TRAIL to Induce Apoptosis in Established Granulosa Cell Tumor Cell Line (KGN) and Explanted Patient Granulosa Cell Tumor Cells In Vitro

  Crosley, P., Farkkila, A., Jenner, AL., Burlot, C., Cardinal, O., Potts, KG., Agopsowicz, K., Pihlajoki, M., Heikinheimo, M., Craig, M., Fu, YX. & Hitt, MM., May 2021, In: International Journal of Molecular Sciences. 22, 9, 17 p., 4699.

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