Kansainvälinen vertaileva tutkimus metabolisen oireyhtymän ja sen osatekijöiden vaikutuksesta sydän-ja verisuonitautiriskiin----sukupuolen, iän ja etnisyyden vaikutus

  • Qiao, Qing (Project manager)

Project Details

Description

The primary objective is to estimate whether a definition of the MetS portend a greater CVD risk than does its individual component or does the European Heart Score, and is worthy of the
definition. The secondary objectives are to find out: 1) Are all risk factors equally important? Do some combinations (of two, three, or four factors) convey greater CVD risk than others? 2) the
ethnic and sex differences in the definition of MetS and its individual components; 3) which of the definitions is the best if there is one; 4) additional values of age, smoking and CVD history and
their relationship to MetS of different definitions.
The data analyses will be performed based on the large existing data sets of the DECODE and the DECODA studies. The two studies
comprised more than 60 cohorts of mainly population-based from 24 countries, with 65903 Europeans and 84207 Asians of Chinese, Japanese, Indians, Mongolians and Philippines. The age
ranges from 25-99 years. 22 European cohorts and 8 Asian cohorts provide with follow-up data on vital status, comprising 7649 all-cause deaths and 4064 CVD deaths in Europeans and 1024
and 455 in Asians, respectively. Various relevant statistical methods will be applied.
Both Finish and international researchers are involved in the project. Five postgraduate research
fellows involved in the project are pursuing their Ph.D degree, and at least 4 doctoral theses will be finished in 5 years.
The results will not only add fuel to the hot debates on the MetS, but
also provide with solid and essential evidence to show the pros and cons about the definitions of the MetS, which will be impossible to be achieved by a single study. This evidence will be very
useful to the decision makers to make an evidence-based definition for the MetS as well as useful in guiding the physicians in their clinical practice. The sub-data-analysis on glucose will
provide valuable information on the new category of IFG (fasting plasma glucose of 5.6-6.0 vs. 6.1-6.9 mmol/l), its relationship with other variables and its impact on CVD morbidity and
mortality. This information is very important for WHO Consultation to make a recommendation on the diagnostic criteria for diabetes and mild abnormalities of glucose metabolism. The
sub-data analysis on the ethnicity will provide with valuable evidence on whether a worldwide uniform definition for MetS and its individual abnormalities is possible or whether different criteria
should be applied for different races. Information on the impact of age and sex will be obtained because the large database ensures a detailed data analysis for sub-groups. All the results will
be published in international peer-reviewed journals and will be disseminated through the DECODE/DECODA network as well as IDF¿ and WHO¿s networks.
StatusFinished
Effective start/end date01/01/201031/07/2011

Funding

  • Unknown funder

Fields of Science

  • 3142 Public health care science, environmental and occupational health
  • diabetes
  • decode
  • decoda