Kinase signaling linking metabolism and growth control

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Project Details

Description (abstract)

Major human diseases such as diabetes and cancer are due to deregulated signaling stemming from genetic alterations and extrinsic factors. Signaling in pathways and in larger networks typically involves sequential activation of kinases phosphorylating substrates and thus relaying and amplifying signals ultimately modulating transcriptional responses in target gene sets. Our longstanding interest is to characterize signaling pathways regulating mammalian cell growth and how these impinge on transcriptional responses in human disease.
Effective start/end date01/01/1996 → …