Medical Physics: BNCT & Medical Imaging (BNCTMI)

Project Details

Description (abstract)

The Boron neutron capture therapy (BNCT) research is conducted by dedicated researchers (RC) con-sisting of physicists, chemists, engineers and physicians from the University of Helsinki (UH) [Depart-ment of Physics, Department of Chemistry, Faculty of Sciences and Centre of Drug Research (CDR), Faculty of Pharmacy], Helsinki University Central Hospital (HUCH) [HUS Helsinki Medical Imaging Cen-ter, HUSLAB and Department of Oncology], VTT Technical Research Centre of Finland, STUK - Radiati-on and Nuclear Safety Authority, Radiation Metrology Laboratory and also from private health care sec-tor.

BNCT is highly challenging and multidisciplinary therapy against cancer. The outcome depends on the complex spatio-temporal distribution of boron and neutron interactions in the tumour. Quantitative imaging of the boron carrier molecules with various modalities (e.g. SPECT/CT, PET/CT, MRI and MRS) is essential for accurate treatment planning, extending from macrodosimetry to cell level microdosimetry. There are various preclinical and clinical problems motivating further research i.e. dosimetric calcula-tions, in vivo dosimetry and imaging, reconstruction and study of new molecular carriers, which the RC have expertise needed for resolving the issues. FiR1 reactor operated by VTT, has been converted into a full-scale BNCT facility. Finnish BNCT Consortium has been established to develop BNCT into a viable cancer treatment by HUCH and VTT. The CDR hosts a nanoSPECT/CT instrument, which enables quantitative, real-time ultra-high resolution 3D morphological imaging and tracking of radiolabeled sub-stances in rodents. The computational materials science group at the Department of Physics at UH de-velops cell cluster models, micro and macro-level dosimetry. Laboratory of Organic Chemistry at the UH, has modern equipment for organic synthesis, sample purification and molecular structure characterizati-on. Research at STUK and Radiation Metrology Laboratory is focused on the detection, dosimetry and safe medical use of radiation.

The RC benefits HUCH by developing novel and improving methods for medical diagnosis and treat-ment. Additionally, the medical physicist specialized training ensures competent experts in the field of medical physics for HUCH. Collaboration between institutes of RC provides a wide range of expertise, warranting multidisciplinary research with highest quality. The Finnish BNCT project has also gained societal vantage point to address the significance of versatile collaboration in natural sciences and medicine, to overcome a type of the most common, yet fatal pathologies of the present Western world.

Responsible person: Sauli Savolainen, Dept. of Physics

Participation category: 2
Effective start/end date22/02/201131/12/2012
  • Custos

    Sauli Savolainen (Supervisor)


    Activity: Examination typesSupervisor or co-supervisor of doctoral thesis