Research output per year
Research output per year
Project Details
Description (abstract)
The project aims to study the mitochondrial proteins such as the ones involved in generating ATP by carrying out complicated electron and proton transfer reactions. These are studied in my group with computational techniques and using high-performance supercomputing. To support computational work a large number of collaborations exist with experimental teams in Finland and abroad.
| Status | Finished |
|---|---|
| Effective start/end date | 01/01/2018 → 31/12/2021 |
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Threshold of heteroplasmic truncating MT-ATP6 mutation in reprogramming, Notch hyperactivation and motor neuron metabolism
Kenvin, S., Torregrosa-Munumer, R., Reidelbach, M., Pennonen, J., Turkia, J. J., Rannila, E., Kvist, J., Sainio, M. T., Huber, N., Herukka, S.-K., Haapasalo, A., Auranen, M., Trokovic, R., Sharma, V., Ylikallio, E. & Tyynismaa, H., 15 Mar 2022, In: Human Molecular Genetics. 31, 6, p. 958-974 17 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
A novel approach to the detection of unusual mitochondrial protein change suggests hypometabolism of ancestral simians
Akpinar, A., Sharma, V. & Dunn, C., 2021, (Unpublished) In: bioRxiv. 36 p.Research output: Contribution to journal › Article › Scientific
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Editorial: Computational and Experimental Insights in Redox-Coupled Proton Pumping in Proteins
Sharma, V., Imhof, P. & Hellwig, P., 15 Sept 2021, In: Frontiers in Chemistry. 9, 2 p., 762612.Research output: Contribution to journal › Editorial › Scientific
Open AccessFile
Datasets
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Snapshots from MD simulations of bacterial and mitochondrial complex I
Sharma, V. (Creator), Zenodo, 2018
Dataset
Activities
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Structural and biochemical studies of a posttranslational modification platform in early Eukaryota
Sharma, V. (Supervisor)
2021Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
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Computational modeling of redox-coupled proton pumping by respiratory complex I
Sharma, V. (Speaker)
2021Activity: Talk or presentation types › Invited talk
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Perspectives in Bioenergetics
Sharma, V. (Attendee)
2021Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Press/Media
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Atomistic insights into the structure of mitochondrial complex I
23/11/2021
1 Media contribution
Press/Media: Press / Media
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Researchers discovered an important role for hydrogen bonding in mitochondrial disease mutation
30/08/2021
1 Media contribution
Press/Media: Press / Media
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Researchers find that accessory subunit plays a key role in biological energy conversion by mitochondrial complex I
02/12/2020
1 Media contribution
Press/Media: Press / Media