Phenotypic biosensor-based HTS and mode of action analysis by metabolomics and transcriptomics for enhancing antimicrobial drug discovery against Gram-negative bacteria

Research output

Research output per year 2015 2015 2016 2017 2018 2019 2020 2020

• 26 Article

Research output per year

Research output per year

Search results

• 2020

  2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa

  McVey, A., Bartlett, S., Kajbaf, M., Pellacani, A., Gatta, V., Tammela, P., Spring, D. R. & Welch, M., 3 Apr 2020, In: International Journal of Molecular Sciences. 21, 7, 16 p., 2490.

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• A new cell-based AI-2-mediated quorum sensing interference assay in screening of LsrK-targeted inhibitors

  Gatta, V., Tomašič, T., Ilaš, J., Zidar, N., Peterlin Mašič, L., Barančoková, M., Frlan, R., Anderluh, M., Kikelj, D. & Tammela, P., 1 Jul 2020, In: ChemBioChem : a European journal of chemical biology. 21, 13, p. 1918-1922 5 p.

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• Chemical Composition and Antibacterial Effect of Mentha spp. Grown in Estonia

  Kapp, K., Püssa, T., Orav, A., Roasto, M., Raal, A., Vuorela, P., Vuorela, H. & Tammela, P., 8 Dec 2020, In: Natural Product Communications. 15, 12, 14 p.

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• Composition and Antibacterial Effect of Mint Flavorings in Candies and Food Supplements

  Kapp, K., Orav, A., Roasto, M., Raal, A., Püssa, T., Vuorela, H., Tammela, P. & Vuorela, P., Oct 2020, In: Planta Medica. 86, 15, p. 1089-1096 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• 2019

  An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors

  Benetto Tiz, D., Skok, Ž., Durcik, M., Tomašič, T., Peterlin Mašič, L., Ilaš, J., Draskovits, G., Révész, T., Nyerges, Á., Pál, C., Cruz, C. D., Tammela, P. S. M., Žigon, D., Kikelj, D. & Zidar, N., 1 Apr 2019, In: European Journal of Medicinal Chemistry. 167, p. 269-290 22 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Identification and characterization of approved drugs and drug-like compounds as covalent Escherichia coli ClpP inhibitors

  Sassetti, E., Cruz, C. D., Tammela, P., Winterhalter, M., Augustyns, K., Gribbon, P. & Windshügel, B., 1 Jun 2019, In: International Journal of Molecular Sciences. 20, 11, 13 p., 2686.

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• New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors

  Zidar, N., Macut, H., Tomašič, T., Peterlin Mašič, L., Ilaš, J., Zega, A., Tammela, P. & Kikelj, D., 1 Jun 2019, In: MedChemComm. 10, 6, p. 1007-1017 11 p.

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• Targeting Quorum Sensing: High-Throughput Screening to Identify Novel LsrK Inhibitors

  Gatta, V., Ilina, P., Porter, A., McElroy, S. & Tammela, P., 2 Jun 2019, In: International Journal of Molecular Sciences. 20, 12, 17 p., 3112.

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• α-Amino diphenyl phosphonates as novel inhibitors of Escherichia coli ClpP protease

  Moreno-Cinos, C., Sassetti, E., Salado, I. G., Witt, G., Benramdane, S., Reinhardt, L., Cruz, C. D., Joossens, J., Van der Veken, P., Brötz-Oesterhelt, H., Tammela, P. S. M., Winterhalter, M., Gribbon, P., Windshügel, B. & Augustyns, K., 24 Jan 2019, In: Journal of Medicinal Chemistry. 62, 2, p. 774-797 24 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• 2018

  Defining conditions for biofilm inhibition and eradication assays for Gram-positive clinical reference strains

  Cruz, C. D., Shah, S. & Tammela, P., 3 Nov 2018, In: BMC Microbiology. 18, 9 p., 173.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Design, Synthesis and Biological Evaluation of 1-Ethyl-3-(thiazol-2-yl)urea Derivatives as Escherichia coli DNA Gyrase Inhibitors

  Tomašič, T., Barančoková, M., Zidar, N., Ilaš, J., Tammela, P. S. M. & Kikelj, D., 3 Jan 2018, In: Archiv der Pharmazie : Chemistry in life sciences. 351, 1, 16 p., e1700333.

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• Marine Microalgae: Promising Source for New Bioactive Compounds

  de Vera, C. R., Díaz Crespín, G., Hernández Daranas, A., Montalvão Looga, S., Lillsunde, K-E., Tammela, P., Perälä, M., Hongisto, V., Virtanen, J., Rischer, H., Muller, C. D., Norte, M., Fernández, J. J. & Souto, M. L., 6 Sept 2018, In: Marine Drugs. 16, 9, 12 p., 317.

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• New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity

  Durcik, M., Lovison, D., Skok, Ž., Durante Cruz, C., Tammela, P., Tomašič, T., Benetto Tiz, D., Draskovits, G., Nyerges, Á., Pál, C., Ilaš, J., Peterlin Mašič, L., Kikelj, D. & Zidar, N., 25 Jun 2018, In: European Journal of Medicinal Chemistry. 154, p. 117-132 16 p.

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• Synthesis and Evaluation of N-Phenylpyrrolamides as DNA Gyrase B Inhibitors

  Durcik, M., Tammela, P. S. M., Barančoková, M., Tomašič, T., Ilaš, J., Kikelj, D. & Zidar, N., 22 Jan 2018, In: ChemMedChem : chemistry enabling drug discovery.. 13, 2, p. 186-198 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• 2017

  Analyzing user-generated online content for drug discovery: Development and use of MedCrawler

  Helfenstein, A. & Tammela, P., 15 Apr 2017, In: Bioinformatics. 33, 8, p. 1205-1209 5 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Antibacterial profiling of abietane-type diterpenoids

  Helfenstein, A., Vahermo, M. M. A., Nawrot, D. A., Demirci, F., İşcan, G., Krogerus, S., Yli-Kauhaluoma, J. T., Moreira, V. M. & Tammela, P. S. M., Jan 2017, In: Bioorganic & Medicinal Chemistry. 25, 1, p. 132-137 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors

  Tomašič, T., Mirt, M., Barančoková, M., Ilaš, J., Zidar, N., Tammela, P. S. M. & Kikelj, D., 1 Jan 2017, In: Bioorganic & Medicinal Chemistry. 25, 1, p. 338-349 12 p.

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• Design, Synthesis and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors

  Cotman, A., Trampuž, M., Brvar, M., Kikelj, D., Ilaš, J., Peterlin-Mašič, L., Montalvao, S. I. G. H., Tammela, P. S. M. & Frlan, R., Aug 2017, In: Archiv der Pharmazie : Chemistry in life sciences. 350, 8, 16 p., 1700087 .

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• Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors

  Jakopin, Z., Ilas, J., Barancokova, M., Brvar, M., Tammela, P., Dolenc, M. S., Tomasic, T. & Kikelj, D., 21 Apr 2017, In: European Journal of Medicinal Chemistry. 130, p. 171-184 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• 2016

  Discovery of bentzothiazole scaffold-based DNA gyrase B inhibitors

  Gjorgjieva, M., Tomašič, T., Barančokova, M., Katsamakas, S., Ilaš, J., Tammela, P., Peterlin Mašič, L. & Kikelj, D., Oct 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8941-8954 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• New N-phenyl-4,5-dibromopyrrolamides and N-phenylindolamides as ATPase inhibitors of DNA gyrase

  Zidar, N., Tomasic, T., Macut, H., Sirc, A., Brvar, M., Montalvao, S., Tammela, P., Ilas, J. & Kikelj, D., 30 Mar 2016, In: European Journal of Medicinal Chemistry. 117, p. 197-211 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Synthesis and Biological Evaluation of 2-Aminobenzothiazole and Benzimidazole Analogs Based on the Clathrodin Structure

  Montalvao, S., Leino, T. O., Kiuru, P. S., Lillsunde, K-E., Yli-Kauhaluoma, J. & Tammela, P., 2 Feb 2016, In: Archiv der Pharmazie : Chemistry in life sciences. 349, 2, p. 137-149 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Synthesis and biological evaluation of crown ether acyl derivatives

  Febles, M., Montalvao, S. I. G. H., Crespín, G. D., Norte, M., Padrón, J. M., Tammela, P. S. M., Fernández, J. J. & Daranas, A. H., Nov 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 22, p. 5591-5593 3 p.

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• 2015

  Acetate-Derived Metabolites from the Brown Alga Lobophora variegata

  Gutiérrez-Cepeda, A., Fernández, J. J., Norte, M., Montalvão, S., Tammela, P. & Souto, M. L., Jul 2015, In: Journal of Natural Products. 78, 7, p. 1716-1722 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Bioluminescent whole-cell reporter gene assays as screening tools in the identification of antimicrobial natural product extracts

  Nybond, S. C. S., Karp, M., Yrjönen, T. J. & Tammela, P. S. M., May 2015, In: Journal of Microbiological Methods. 114, p. 54-56 3 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Integrated in vitro - in silico screening strategy for the discovery of antibacterial compounds

  Nybond, S., Ghemtio, L., Nawrot, D., Karp, M., Xhaard, H. & Tammela, P., 2015, In: Assay and drug development technologies. 13, 1, p. 25-33 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review