3-Hydroxyanthralinic acid Metabolism Controls the Hepatic Srebp/Lipoprotein axis, Inhibits Inflammasome Activation in Macrophages, and Decreases Atherosclerosis in LDLR-/- Mice

Martin Berg, Konstantinos A Polyzos, Hanna Agardh, Roland Baumgartner, Maria J Forteza, Ilona Kareinen, Anton Gisterå, Gerhard Bottcher, Eva Hurt-Camejo, Göran K Hansson, Daniel F J Ketelhuth

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalCardiovascular Research
Volume116
Issue number12
Pages (from-to)1948-1957
ISSN0008-6363
DOIs
Publication statusPublished - 2020
Externally publishedYes
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3-hydroxyanthranilic acid
  • apolipoproteins b
  • atherogenesis
  • atherosclerosis
  • bodily secretions
  • cardiovascular diseases
  • catabolism
  • cell culture techniques
  • dioxygenases
  • fat metabolism
  • hypercholesterolemia
  • hyperlipidemia
  • immune cell activation
  • immune response
  • inflammasomes
  • inflammation
  • inflammatory disorders
  • kynurenine
  • lipids
  • lipoproteins
  • liver
  • low density lipoprotein receptor
  • macrophages
  • metabolism
  • metabolites
  • mice
  • nuclear translocation
  • pathology
  • plasma
  • rna
  • messenger
  • signal pathway
  • signal transduction pathways
  • tryptophan
  • 3121 General medicine, internal medicine and other clinical medicine

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