A common missense variant of LILRB5 is associated with statin intolerance and myalgia

Moneeza K. Siddiqui; Cyrielle Maroteau; Abirami Veluchamy; Aleksi Tornio; Roger Tavendale; Fiona Carr; Ngu-Uma Abelega; Dan Carr; Katyrzyna Bloch; Par Hallberg; Qun-Ying Yue; Ewan R. Pearson; Helen M. Colhoun; Andrew D. Morris; Eleanor Dow; Jacob George; Munir Pirmohamed; Paul M. Ridker; Alex S. F. Doney; Ana Alfirevic; Mia Wadelius; Anke-Hilse Maitland-van der Zee; Daniel I. Chasman; Colin N. A. Palmer; PREDICTION-ADR Consortium

doi:10.1093/eurheartj/ehx467

A common missense variant of LILRB5 is associated with statin intolerance and myalgia

Moneeza K. Siddiqui, Cyrielle Maroteau, Abirami Veluchamy, Aleksi Tornio, Roger Tavendale, Fiona Carr, Ngu-Uma Abelega, Dan Carr, Katyrzyna Bloch, Par Hallberg, Qun-Ying Yue, Ewan R. Pearson, Helen M. Colhoun, Andrew D. Morris, Eleanor Dow, Jacob George, Munir Pirmohamed, Paul M. Ridker, Alex S. F. Doney, Ana AlfirevicMia Wadelius, Anke-Hilse Maitland-van der Zee, Daniel I. Chasman, Colin N. A. Palmer, PREDICTION-ADR Consortium

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	European Heart Journal
Volume	38
Issue number	48
Pages (from-to)	3569-3575
Number of pages	7
ISSN	0195-668X
DOIs	https://doi.org/10.1093/eurheartj/ehx467
Publication status	Published - 21 Dec 2017
Externally published	Yes
MoE publication type	A1 Journal article-refereed

Fields of Science

Statins
Pharmacogenetics
Immunogenetics
Precision medicine
Adverse drug reactions
Myalgia
REGULATORY T-CELLS
SKELETAL-MUSCLE
CARDIOVASCULAR-DISEASE
INDUCED MYOTOXICITY
CLINICAL-PRACTICE
CHOLESTEROL
MYOPATHY
ROSUVASTATIN
PREVENTION
EFFICACY

Access to Document

10.1093/eurheartj/ehx467

Cite this

Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., Abelega, N.-U., Carr, D., Bloch, K., Hallberg, P., Yue, Q.-Y., Pearson, E. R., Colhoun, H. M., Morris, A. D., Dow, E., George, J., Pirmohamed, M., Ridker, P. M., Doney, A. S. F., ... PREDICTION-ADR Consortium (2017). A common missense variant of LILRB5 is associated with statin intolerance and myalgia. European Heart Journal, 38(48), 3569-3575. https://doi.org/10.1093/eurheartj/ehx467

@article{0574e170225a4f8b8982749c3c2d223f,

title = "A common missense variant of LILRB5 is associated with statin intolerance and myalgia",

keywords = "Statins, Pharmacogenetics, Immunogenetics, Precision medicine, Adverse drug reactions, Myalgia, REGULATORY T-CELLS, SKELETAL-MUSCLE, CARDIOVASCULAR-DISEASE, INDUCED MYOTOXICITY, CLINICAL-PRACTICE, CHOLESTEROL, MYOPATHY, ROSUVASTATIN, PREVENTION, EFFICACY",

author = "Siddiqui, {Moneeza K.} and Cyrielle Maroteau and Abirami Veluchamy and Aleksi Tornio and Roger Tavendale and Fiona Carr and Ngu-Uma Abelega and Dan Carr and Katyrzyna Bloch and Par Hallberg and Qun-Ying Yue and Pearson, {Ewan R.} and Colhoun, {Helen M.} and Morris, {Andrew D.} and Eleanor Dow and Jacob George and Munir Pirmohamed and Ridker, {Paul M.} and Doney, {Alex S. F.} and Ana Alfirevic and Mia Wadelius and {Maitland-van der Zee}, Anke-Hilse and Chasman, {Daniel I.} and Palmer, {Colin N. A.} and {PREDICTION-ADR Consortium}",

year = "2017",

month = dec,

day = "21",

doi = "10.1093/eurheartj/ehx467",

language = "English",

volume = "38",

pages = "3569--3575",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "48",

}

Siddiqui, MK, Maroteau, C, Veluchamy, A, Tornio, A, Tavendale, R, Carr, F, Abelega, N-U, Carr, D, Bloch, K, Hallberg, P, Yue, Q-Y, Pearson, ER, Colhoun, HM, Morris, AD, Dow, E, George, J, Pirmohamed, M, Ridker, PM, Doney, ASF, Alfirevic, A, Wadelius, M, Maitland-van der Zee, A-H, Chasman, DI, Palmer, CNA & PREDICTION-ADR Consortium 2017, 'A common missense variant of LILRB5 is associated with statin intolerance and myalgia', European Heart Journal, vol. 38, no. 48, pp. 3569-3575. https://doi.org/10.1093/eurheartj/ehx467

TY - JOUR

T1 - A common missense variant of LILRB5 is associated with statin intolerance and myalgia

AU - Siddiqui, Moneeza K.

AU - Maroteau, Cyrielle

AU - Veluchamy, Abirami

AU - Tornio, Aleksi

AU - Tavendale, Roger

AU - Carr, Fiona

AU - Abelega, Ngu-Uma

AU - Carr, Dan

AU - Bloch, Katyrzyna

AU - Hallberg, Par

AU - Yue, Qun-Ying

AU - Pearson, Ewan R.

AU - Colhoun, Helen M.

AU - Morris, Andrew D.

AU - Dow, Eleanor

AU - George, Jacob

AU - Pirmohamed, Munir

AU - Ridker, Paul M.

AU - Doney, Alex S. F.

AU - Alfirevic, Ana

AU - Wadelius, Mia

AU - Maitland-van der Zee, Anke-Hilse

AU - Chasman, Daniel I.

AU - Palmer, Colin N. A.

AU - PREDICTION-ADR Consortium

PY - 2017/12/21

Y1 - 2017/12/21

KW - Statins

KW - Pharmacogenetics

KW - Immunogenetics

KW - Precision medicine

KW - Adverse drug reactions

KW - Myalgia

KW - REGULATORY T-CELLS

KW - SKELETAL-MUSCLE

KW - CARDIOVASCULAR-DISEASE

KW - INDUCED MYOTOXICITY

KW - CLINICAL-PRACTICE

KW - CHOLESTEROL

KW - MYOPATHY

KW - ROSUVASTATIN

KW - PREVENTION

KW - EFFICACY

U2 - 10.1093/eurheartj/ehx467

DO - 10.1093/eurheartj/ehx467

M3 - Article

SN - 0195-668X

VL - 38

SP - 3569

EP - 3575

JO - European Heart Journal

JF - European Heart Journal

IS - 48

ER -