A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions

Joni Nikkanen, Juan Cruz Landoni, Diego Balboa, Maarja Haugas, Juha Partanen, Anders Paetau, Pirjo Isohanni, Virginia Brilhante, Anu Suomalainen

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalEMBO molecular medicine
Volume10
Issue number1
Pages (from-to)13-21
Number of pages9
ISSN1757-4676
DOIs
Publication statusPublished - Jan 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • enhancer
  • gene regulation
  • mtDNA maintenance
  • POLG
  • tissue specificity
  • MITOCHONDRIAL-DNA POLYMERASE
  • PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA
  • GAMMA MUTATIONS
  • RECESSIVE ATAXIA
  • LANDSCAPE
  • CHROMATIN
  • BRAIN
  • CELLS
  • MICE
  • 3112 Neurosciences
  • 3124 Neurology and psychiatry
  • 3111 Biomedicine

Cite this

@article{6c450cfceaa54d0d81c2fb00041c45ba,
title = "A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions",
keywords = "enhancer, gene regulation, mtDNA maintenance, POLG, tissue specificity, MITOCHONDRIAL-DNA POLYMERASE, PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA, GAMMA MUTATIONS, RECESSIVE ATAXIA, LANDSCAPE, CHROMATIN, BRAIN, CELLS, MICE, 3112 Neurosciences, 3124 Neurology and psychiatry, 3111 Biomedicine",
author = "Joni Nikkanen and Landoni, {Juan Cruz} and Diego Balboa and Maarja Haugas and Juha Partanen and Anders Paetau and Pirjo Isohanni and Virginia Brilhante and Anu Suomalainen",
year = "2018",
month = "1",
doi = "10.15252/emmm.201707993",
language = "English",
volume = "10",
pages = "13--21",
journal = "EMBO molecular medicine",
issn = "1757-4676",
publisher = "Wiley",
number = "1",

}

A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions. / Nikkanen, Joni; Landoni, Juan Cruz; Balboa, Diego; Haugas, Maarja; Partanen, Juha; Paetau, Anders; Isohanni, Pirjo; Brilhante, Virginia; Suomalainen, Anu.

In: EMBO molecular medicine, Vol. 10, No. 1, 01.2018, p. 13-21.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions

AU - Nikkanen, Joni

AU - Landoni, Juan Cruz

AU - Balboa, Diego

AU - Haugas, Maarja

AU - Partanen, Juha

AU - Paetau, Anders

AU - Isohanni, Pirjo

AU - Brilhante, Virginia

AU - Suomalainen, Anu

PY - 2018/1

Y1 - 2018/1

KW - enhancer

KW - gene regulation

KW - mtDNA maintenance

KW - POLG

KW - tissue specificity

KW - MITOCHONDRIAL-DNA POLYMERASE

KW - PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA

KW - GAMMA MUTATIONS

KW - RECESSIVE ATAXIA

KW - LANDSCAPE

KW - CHROMATIN

KW - BRAIN

KW - CELLS

KW - MICE

KW - 3112 Neurosciences

KW - 3124 Neurology and psychiatry

KW - 3111 Biomedicine

U2 - 10.15252/emmm.201707993

DO - 10.15252/emmm.201707993

M3 - Article

VL - 10

SP - 13

EP - 21

JO - EMBO molecular medicine

JF - EMBO molecular medicine

SN - 1757-4676

IS - 1

ER -