A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions

Joni Nikkanen, Juan Cruz Landoni, Diego Balboa, Maarja Haugas, Juha Partanen, Anders Paetau, Pirjo Isohanni, Virginia Brilhante, Anu Suomalainen

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalEMBO molecular medicine
Volume10
Issue number1
Pages (from-to)13-21
Number of pages9
ISSN1757-4676
DOIs
Publication statusPublished - Jan 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • enhancer
  • gene regulation
  • mtDNA maintenance
  • POLG
  • tissue specificity
  • MITOCHONDRIAL-DNA POLYMERASE
  • PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA
  • GAMMA MUTATIONS
  • RECESSIVE ATAXIA
  • LANDSCAPE
  • CHROMATIN
  • BRAIN
  • CELLS
  • MICE
  • 3112 Neurosciences
  • 3124 Neurology and psychiatry
  • 3111 Biomedicine

Cite this