A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials:: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides

Leena Keurulainen; Mikko Vahermo; Margarita Puente-Felipe; Elena Sandoval-Izquierdo; Benigno Crespo-Fernandez; Laura Guijarro-Lopez; Leticia Huertas-Valentin; Laura de las Heras-Duena; Teppo O. Leino; Antti Siiskonen; Lluis Balla-Pages; Laura M. Sanz; Pablo Castaneda-Casado; M. Belen Jimenez-Diaz; Maria S. Martinez-Martinez; Sara Viera; Paula Kiuru; Felix Calderon; Jari Yli-Kauhaluoma

doi:10.1021/acs.jmedchem.5b00114

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides

Leena Keurulainen, Mikko Vahermo, Margarita Puente-Felipe, Elena Sandoval-Izquierdo, Benigno Crespo-Fernandez, Laura Guijarro-Lopez, Leticia Huertas-Valentin, Laura de las Heras-Duena, Teppo O. Leino, Antti Siiskonen, Lluis Balla-Pages, Laura M. Sanz, Pablo Castaneda-Casado, M. Belen Jimenez-Diaz, Maria S. Martinez-Martinez, Sara Viera, Paula Kiuru, Felix Calderon, Jari Yli-Kauhaluoma

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Journal of Medicinal Chemistry
Volume	58
Issue number	11
Pages (from-to)	4573-4580
Number of pages	8
ISSN	0022-2623
DOIs	https://doi.org/10.1021/acs.jmedchem.5b00114
Publication status	Published - 11 Jun 2015
MoE publication type	A1 Journal article-refereed

Fields of Science

PLASMODIUM-FALCIPARUM
STARTING POINTS
DE-POINTES
MALARIA
BENZIMIDAZOLES
PROLONGATION
TCAMS
317 Pharmacy

Access to Document

10.1021/acs.jmedchem.5b00114

Tres Cantos Open Lab Foundation: Identifying benzimidazole-derived leads against <em>Plasmodium falciparum</em>
Keurulainen, L. (Participant), Kiuru, P. (Participant), Vahermo, M. (Participant) & Yli-Kauhaluoma, J. (Project manager)
01/01/2013 → 31/12/2013
Project: Research project

Cite this

Keurulainen, L., Vahermo, M., Puente-Felipe, M., Sandoval-Izquierdo, E., Crespo-Fernandez, B., Guijarro-Lopez, L., Huertas-Valentin, L., de las Heras-Duena, L., Leino, T. O., Siiskonen, A., Balla-Pages, L., Sanz, L. M., Castaneda-Casado, P., Belen Jimenez-Diaz, M., Martinez-Martinez, M. S., Viera, S., Kiuru, P., Calderon, F., & Yli-Kauhaluoma, J. (2015). A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides. Journal of Medicinal Chemistry, 58(11), 4573-4580. https://doi.org/10.1021/acs.jmedchem.5b00114

@article{21e247feddaf4e77bcab48565506863b,

title = "A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials:: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides",

keywords = "PLASMODIUM-FALCIPARUM, STARTING POINTS, DE-POINTES, MALARIA, BENZIMIDAZOLES, PROLONGATION, TCAMS, 317 Pharmacy",

author = "Leena Keurulainen and Mikko Vahermo and Margarita Puente-Felipe and Elena Sandoval-Izquierdo and Benigno Crespo-Fernandez and Laura Guijarro-Lopez and Leticia Huertas-Valentin and {de las Heras-Duena}, Laura and Leino, {Teppo O.} and Antti Siiskonen and Lluis Balla-Pages and Sanz, {Laura M.} and Pablo Castaneda-Casado and {Belen Jimenez-Diaz}, M. and Martinez-Martinez, {Maria S.} and Sara Viera and Paula Kiuru and Felix Calderon and Jari Yli-Kauhaluoma",

year = "2015",

month = jun,

day = "11",

doi = "10.1021/acs.jmedchem.5b00114",

language = "English",

volume = "58",

pages = "4573--4580",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "11",

}

Keurulainen, L, Vahermo, M, Puente-Felipe, M, Sandoval-Izquierdo, E, Crespo-Fernandez, B, Guijarro-Lopez, L, Huertas-Valentin, L, de las Heras-Duena, L, Leino, TO, Siiskonen, A, Balla-Pages, L, Sanz, LM, Castaneda-Casado, P, Belen Jimenez-Diaz, M, Martinez-Martinez, MS, Viera, S, Kiuru, P, Calderon, F & Yli-Kauhaluoma, J 2015, 'A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides', Journal of Medicinal Chemistry, vol. 58, no. 11, pp. 4573-4580. https://doi.org/10.1021/acs.jmedchem.5b00114

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides. / Keurulainen, Leena; Vahermo, Mikko; Puente-Felipe, Margarita et al.
In: Journal of Medicinal Chemistry, Vol. 58, No. 11, 11.06.2015, p. 4573-4580.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials:

T2 - N-[3-[(Benzimidazol-2-yl)amino]propyl]amides

AU - Keurulainen, Leena

AU - Vahermo, Mikko

AU - Puente-Felipe, Margarita

AU - Sandoval-Izquierdo, Elena

AU - Crespo-Fernandez, Benigno

AU - Guijarro-Lopez, Laura

AU - Huertas-Valentin, Leticia

AU - de las Heras-Duena, Laura

AU - Leino, Teppo O.

AU - Siiskonen, Antti

AU - Balla-Pages, Lluis

AU - Sanz, Laura M.

AU - Castaneda-Casado, Pablo

AU - Belen Jimenez-Diaz, M.

AU - Martinez-Martinez, Maria S.

AU - Viera, Sara

AU - Kiuru, Paula

AU - Calderon, Felix

AU - Yli-Kauhaluoma, Jari

PY - 2015/6/11

Y1 - 2015/6/11

KW - PLASMODIUM-FALCIPARUM

KW - STARTING POINTS

KW - DE-POINTES

KW - MALARIA

KW - BENZIMIDAZOLES

KW - PROLONGATION

KW - TCAMS

KW - 317 Pharmacy

U2 - 10.1021/acs.jmedchem.5b00114

DO - 10.1021/acs.jmedchem.5b00114

M3 - Article

SN - 0022-2623

VL - 58

SP - 4573

EP - 4580

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 11

ER -

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides

Fields of Science

Access to Document

Projects

Tres Cantos Open Lab Foundation: Identifying benzimidazole-derived leads against <em>Plasmodium falciparum</em>

Cite this