A framework for space-efficient variable-order Markov models

Fabio Cunial, Jarno Alanko, Djamal Belazzougui

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Motivation

Markov models with contexts of variable length are widely used in bioinformatics for representing sets of sequences with similar biological properties. When models contain many long contexts, existing implementations are either unable to handle genome-scale training datasets within typical memory budgets, or they are optimized for specific model variants and are thus inflexible.
Results

We provide practical, versatile representations of variable-order Markov models and of interpolated Markov models, that support a large number of context-selection criteria, scoring functions, probability smoothing methods, and interpolations, and that take up to four times less space than previous implementations based on the suffix array, regardless of the number and length of contexts, and up to ten times less space than previous trie-based representations, or more, while matching the size of related, state-of-the-art data structures from Natural Language Processing. We describe how to further compress our indexes to a quantity related to the redundancy of the training data, saving up to 90% of their space on very repetitive datasets, and making them become up to 60 times smaller than previous implementations based on the suffix array. Finally, we show how to exploit constraints on the length and frequency of contexts to further shrink our compressed indexes to half of their size or more, achieving data structures that are a hundred times smaller than previous implementations based on the suffix array, or more. This allows variable-order Markov models to be used with bigger datasets and with longer contexts on the same hardware, thus possibly enabling new applications.
Original languageEnglish
JournalBioinformatics
Volume35
Issue number22
Pages (from-to)4607-4616
Number of pages10
ISSN1367-4803
DOIs
Publication statusPublished - 15 Nov 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 113 Computer and information sciences
  • Data Structures
  • 1184 Genetics, developmental biology, physiology
  • bioinformatics

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