A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

Ida Surakka; Aaron Isaacs; Lennart C. Karssen; Pirkka-Pekka P. Laurila; Rita P. S. Middelberg; Emmi Tikkanen; Janina S. Ried; Claudia Lamina; Massimo Mangino; Wilmar Igl; Jouke-Jan Hottenga; Vasiliki Lagou; Pim van der Harst; Irene Mateo Leach; Tonu Esko; Zoltan Kutalik; Nicholas W. Wainwright; Maksim V. Struchalin; Antti-Pekka Sarin; Antti J. Kangas; Jorma S. Viikari; Markus Perola; Taina Rantanen; Ann-Kristin Petersen; Pasi Soininen; Asa Johansson; Nicole Soranzo; Andrew C. Heath; Theodore Papamarkou; Inga Prokopenko; Anke Toenjes; Florian Kronenberg; Angela Doering; Fernando Rivadeneira; Grant W. Montgomery; John B. Whitfield; Mika Kahonen; Terho Lehtimaki; Nelson B. Freimer; Gonneke Willemsen; Eco J. C. de Geus; Aarno Palotie; Manj S. Sandhu; Dawn M. Waterworth; Andres Metspalu; Michael Stumvoll; Andre G. Uitterlinden; Antti Jula; Gerjan Navis; Cisca Wijmenga; Bruce H. R. Wolffenbuttel; Marja-Riitta Taskinen; Mika Ala-Korpela; Jaakko Kaprio; Kirsten O. Kyvik; Dorret I. Boomsma; Nancy L. Pedersen; Ulf Gyllensten; James F. Wilson; Igor Rudan; Harry Campbell; Peter P. Pramstaller; Tim D. Spector; Jacqueline C. M. Witteman; Johan G. Eriksson; Veikko Salomaa; Ben A. Oostra; Olli T. Raitakari; H. -Erich Wichmann; Christian Gieger; Marjo-Riitta Jaervelin; Nicholas G. Martin; Albert Hofman; Mark I. McCarthy; Leena Palotie; Cornelia M. van Duijn; Yurii S. Aulchenko; Samuli Ripatti

doi:10.1371/journal.pgen.1002333

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

Ida Surakka, Aaron Isaacs, Lennart C. Karssen, Pirkka-Pekka P. Laurila, Rita P. S. Middelberg, Emmi Tikkanen, Janina S. Ried, Claudia Lamina, Massimo Mangino, Wilmar Igl, Jouke-Jan Hottenga, Vasiliki Lagou, Pim van der Harst, Irene Mateo Leach, Tonu Esko, Zoltan Kutalik, Nicholas W. Wainwright, Maksim V. Struchalin, Antti-Pekka Sarin, Antti J. KangasJorma S. Viikari, Markus Perola, Taina Rantanen, Ann-Kristin Petersen, Pasi Soininen, Asa Johansson, Nicole Soranzo, Andrew C. Heath, Theodore Papamarkou, Inga Prokopenko, Anke Toenjes, Florian Kronenberg, Angela Doering, Fernando Rivadeneira, Grant W. Montgomery, John B. Whitfield, Mika Kahonen, Terho Lehtimaki, Nelson B. Freimer, Gonneke Willemsen, Eco J. C. de Geus, Aarno Palotie, Manj S. Sandhu, Dawn M. Waterworth, Andres Metspalu, Michael Stumvoll, Andre G. Uitterlinden, Antti Jula, Gerjan Navis, Cisca Wijmenga, Bruce H. R. Wolffenbuttel, Marja-Riitta Taskinen, Mika Ala-Korpela, Jaakko Kaprio, Kirsten O. Kyvik, Dorret I. Boomsma, Nancy L. Pedersen, Ulf Gyllensten, James F. Wilson, Igor Rudan, Harry Campbell, Peter P. Pramstaller, Tim D. Spector, Jacqueline C. M. Witteman, Johan G. Eriksson, Veikko Salomaa, Ben A. Oostra, Olli T. Raitakari, H. -Erich Wichmann, Christian Gieger, Marjo-Riitta Jaervelin, Nicholas G. Martin, Albert Hofman, Mark I. McCarthy, Leena Palotie, Cornelia M. van Duijn, Yurii S. Aulchenko, Samuli Ripatti

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	PLoS Genetics
Volume	7
Issue number	10
Pages (from-to)	e1002333
Number of pages	8
ISSN	1553-7390
DOIs	https://doi.org/10.1371/journal.pgen.1002333
Publication status	Published - 2011
MoE publication type	A1 Journal article-refereed

Fields of Science

DENSITY-LIPOPROTEIN CHOLESTEROL
HDL CHOLESTEROL
ASSOCIATION
GENE
SMOKING
PLASMA
TRIGLYCERIDE
OBESITY
LIPIDS
POLYMORPHISMS
3111 Biomedicine

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10.1371/journal.pgen.1002333

A Genome-Wide Screen for Interactions Reveals a NewFinal published version, 305 KBLicence: CC BY

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Surakka, I., Isaacs, A., Karssen, L. C., Laurila, P-P. P., Middelberg, R. P. S., Tikkanen, E., Ried, J. S., Lamina, C., Mangino, M., Igl, W., Hottenga, J-J., Lagou, V., van der Harst, P., Leach, I. M., Esko, T., Kutalik, Z., Wainwright, N. W., Struchalin, M. V., Sarin, A-P., ... Ripatti, S. (2011). A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol. PLoS Genetics, 7(10), e1002333. https://doi.org/10.1371/journal.pgen.1002333

Surakka, Ida ; Isaacs, Aaron ; Karssen, Lennart C. ; Laurila, Pirkka-Pekka P. ; Middelberg, Rita P. S. ; Tikkanen, Emmi ; Ried, Janina S. ; Lamina, Claudia ; Mangino, Massimo ; Igl, Wilmar ; Hottenga, Jouke-Jan ; Lagou, Vasiliki ; van der Harst, Pim ; Leach, Irene Mateo ; Esko, Tonu ; Kutalik, Zoltan ; Wainwright, Nicholas W. ; Struchalin, Maksim V. ; Sarin, Antti-Pekka ; Kangas, Antti J. ; Viikari, Jorma S. ; Perola, Markus ; Rantanen, Taina ; Petersen, Ann-Kristin ; Soininen, Pasi ; Johansson, Asa ; Soranzo, Nicole ; Heath, Andrew C. ; Papamarkou, Theodore ; Prokopenko, Inga ; Toenjes, Anke ; Kronenberg, Florian ; Doering, Angela ; Rivadeneira, Fernando ; Montgomery, Grant W. ; Whitfield, John B. ; Kahonen, Mika ; Lehtimaki, Terho ; Freimer, Nelson B. ; Willemsen, Gonneke ; de Geus, Eco J. C. ; Palotie, Aarno ; Sandhu, Manj S. ; Waterworth, Dawn M. ; Metspalu, Andres ; Stumvoll, Michael ; Uitterlinden, Andre G. ; Jula, Antti ; Navis, Gerjan ; Wijmenga, Cisca ; Wolffenbuttel, Bruce H. R. ; Taskinen, Marja-Riitta ; Ala-Korpela, Mika ; Kaprio, Jaakko ; Kyvik, Kirsten O. ; Boomsma, Dorret I. ; Pedersen, Nancy L. ; Gyllensten, Ulf ; Wilson, James F. ; Rudan, Igor ; Campbell, Harry ; Pramstaller, Peter P. ; Spector, Tim D. ; Witteman, Jacqueline C. M. ; Eriksson, Johan G. ; Salomaa, Veikko ; Oostra, Ben A. ; Raitakari, Olli T. ; Wichmann, H. -Erich ; Gieger, Christian ; Jaervelin, Marjo-Riitta ; Martin, Nicholas G. ; Hofman, Albert ; McCarthy, Mark I. ; Palotie, Leena ; van Duijn, Cornelia M. ; Aulchenko, Yurii S. ; Ripatti, Samuli. / A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol. In: PLoS Genetics. 2011 ; Vol. 7, No. 10. pp. e1002333.

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title = "A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol",

keywords = "DENSITY-LIPOPROTEIN CHOLESTEROL, HDL CHOLESTEROL, ASSOCIATION, GENE, SMOKING, PLASMA, TRIGLYCERIDE, OBESITY, LIPIDS, POLYMORPHISMS, 3111 Biomedicine",

author = "Ida Surakka and Aaron Isaacs and Karssen, {Lennart C.} and Laurila, {Pirkka-Pekka P.} and Middelberg, {Rita P. S.} and Emmi Tikkanen and Ried, {Janina S.} and Claudia Lamina and Massimo Mangino and Wilmar Igl and Jouke-Jan Hottenga and Vasiliki Lagou and {van der Harst}, Pim and Leach, {Irene Mateo} and Tonu Esko and Zoltan Kutalik and Wainwright, {Nicholas W.} and Struchalin, {Maksim V.} and Antti-Pekka Sarin and Kangas, {Antti J.} and Viikari, {Jorma S.} and Markus Perola and Taina Rantanen and Ann-Kristin Petersen and Pasi Soininen and Asa Johansson and Nicole Soranzo and Heath, {Andrew C.} and Theodore Papamarkou and Inga Prokopenko and Anke Toenjes and Florian Kronenberg and Angela Doering and Fernando Rivadeneira and Montgomery, {Grant W.} and Whitfield, {John B.} and Mika Kahonen and Terho Lehtimaki and Freimer, {Nelson B.} and Gonneke Willemsen and {de Geus}, {Eco J. C.} and Aarno Palotie and Sandhu, {Manj S.} and Waterworth, {Dawn M.} and Andres Metspalu and Michael Stumvoll and Uitterlinden, {Andre G.} and Antti Jula and Gerjan Navis and Cisca Wijmenga and Wolffenbuttel, {Bruce H. R.} and Marja-Riitta Taskinen and Mika Ala-Korpela and Jaakko Kaprio and Kyvik, {Kirsten O.} and Boomsma, {Dorret I.} and Pedersen, {Nancy L.} and Ulf Gyllensten and Wilson, {James F.} and Igor Rudan and Harry Campbell and Pramstaller, {Peter P.} and Spector, {Tim D.} and Witteman, {Jacqueline C. M.} and Eriksson, {Johan G.} and Veikko Salomaa and Oostra, {Ben A.} and Raitakari, {Olli T.} and Wichmann, {H. -Erich} and Christian Gieger and Marjo-Riitta Jaervelin and Martin, {Nicholas G.} and Albert Hofman and McCarthy, {Mark I.} and Leena Palotie and {van Duijn}, {Cornelia M.} and Aulchenko, {Yurii S.} and Samuli Ripatti",

year = "2011",

doi = "10.1371/journal.pgen.1002333",

language = "English",

volume = "7",

pages = "e1002333",

journal = "PLoS Genetics",

issn = "1553-7390",

publisher = "PUBLIC LIBRARY OF SCIENCE",

number = "10",

}

Surakka, I, Isaacs, A, Karssen, LC, Laurila, P-PP, Middelberg, RPS, Tikkanen, E, Ried, JS, Lamina, C, Mangino, M, Igl, W, Hottenga, J-J, Lagou, V, van der Harst, P, Leach, IM, Esko, T, Kutalik, Z, Wainwright, NW, Struchalin, MV, Sarin, A-P, Kangas, AJ, Viikari, JS, Perola, M, Rantanen, T, Petersen, A-K, Soininen, P, Johansson, A, Soranzo, N, Heath, AC, Papamarkou, T, Prokopenko, I, Toenjes, A, Kronenberg, F, Doering, A, Rivadeneira, F, Montgomery, GW, Whitfield, JB, Kahonen, M, Lehtimaki, T, Freimer, NB, Willemsen, G, de Geus, EJC, Palotie, A, Sandhu, MS, Waterworth, DM, Metspalu, A, Stumvoll, M, Uitterlinden, AG, Jula, A, Navis, G, Wijmenga, C, Wolffenbuttel, BHR, Taskinen, M-R, Ala-Korpela, M, Kaprio, J, Kyvik, KO, Boomsma, DI, Pedersen, NL, Gyllensten, U, Wilson, JF, Rudan, I, Campbell, H, Pramstaller, PP, Spector, TD, Witteman, JCM, Eriksson, JG, Salomaa, V, Oostra, BA, Raitakari, OT, Wichmann, H-E, Gieger, C, Jaervelin, M-R, Martin, NG, Hofman, A, McCarthy, MI, Palotie, L, van Duijn, CM, Aulchenko, YS & Ripatti, S 2011, 'A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol', PLoS Genetics, vol. 7, no. 10, pp. e1002333. https://doi.org/10.1371/journal.pgen.1002333

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol. / Surakka, Ida; Isaacs, Aaron; Karssen, Lennart C.; Laurila, Pirkka-Pekka P.; Middelberg, Rita P. S.; Tikkanen, Emmi; Ried, Janina S.; Lamina, Claudia; Mangino, Massimo; Igl, Wilmar; Hottenga, Jouke-Jan; Lagou, Vasiliki; van der Harst, Pim; Leach, Irene Mateo; Esko, Tonu; Kutalik, Zoltan; Wainwright, Nicholas W.; Struchalin, Maksim V.; Sarin, Antti-Pekka; Kangas, Antti J.; Viikari, Jorma S.; Perola, Markus; Rantanen, Taina; Petersen, Ann-Kristin; Soininen, Pasi; Johansson, Asa; Soranzo, Nicole; Heath, Andrew C.; Papamarkou, Theodore; Prokopenko, Inga; Toenjes, Anke; Kronenberg, Florian; Doering, Angela; Rivadeneira, Fernando; Montgomery, Grant W.; Whitfield, John B.; Kahonen, Mika; Lehtimaki, Terho; Freimer, Nelson B.; Willemsen, Gonneke; de Geus, Eco J. C.; Palotie, Aarno; Sandhu, Manj S.; Waterworth, Dawn M.; Metspalu, Andres; Stumvoll, Michael; Uitterlinden, Andre G.; Jula, Antti; Navis, Gerjan; Wijmenga, Cisca; Wolffenbuttel, Bruce H. R.; Taskinen, Marja-Riitta; Ala-Korpela, Mika; Kaprio, Jaakko; Kyvik, Kirsten O.; Boomsma, Dorret I.; Pedersen, Nancy L.; Gyllensten, Ulf; Wilson, James F.; Rudan, Igor; Campbell, Harry; Pramstaller, Peter P.; Spector, Tim D.; Witteman, Jacqueline C. M.; Eriksson, Johan G.; Salomaa, Veikko; Oostra, Ben A.; Raitakari, Olli T.; Wichmann, H. -Erich; Gieger, Christian; Jaervelin, Marjo-Riitta; Martin, Nicholas G.; Hofman, Albert; McCarthy, Mark I.; Palotie, Leena; van Duijn, Cornelia M.; Aulchenko, Yurii S.; Ripatti, Samuli.

In: PLoS Genetics, Vol. 7, No. 10, 2011, p. e1002333.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

AU - Surakka, Ida

AU - Isaacs, Aaron

AU - Karssen, Lennart C.

AU - Laurila, Pirkka-Pekka P.

AU - Middelberg, Rita P. S.

AU - Tikkanen, Emmi

AU - Ried, Janina S.

AU - Lamina, Claudia

AU - Mangino, Massimo

AU - Igl, Wilmar

AU - Hottenga, Jouke-Jan

AU - Lagou, Vasiliki

AU - van der Harst, Pim

AU - Leach, Irene Mateo

AU - Esko, Tonu

AU - Kutalik, Zoltan

AU - Wainwright, Nicholas W.

AU - Struchalin, Maksim V.

AU - Sarin, Antti-Pekka

AU - Kangas, Antti J.

AU - Viikari, Jorma S.

AU - Perola, Markus

AU - Rantanen, Taina

AU - Petersen, Ann-Kristin

AU - Soininen, Pasi

AU - Johansson, Asa

AU - Soranzo, Nicole

AU - Heath, Andrew C.

AU - Papamarkou, Theodore

AU - Prokopenko, Inga

AU - Toenjes, Anke

AU - Kronenberg, Florian

AU - Doering, Angela

AU - Rivadeneira, Fernando

AU - Montgomery, Grant W.

AU - Whitfield, John B.

AU - Kahonen, Mika

AU - Lehtimaki, Terho

AU - Freimer, Nelson B.

AU - Willemsen, Gonneke

AU - de Geus, Eco J. C.

AU - Palotie, Aarno

AU - Sandhu, Manj S.

AU - Waterworth, Dawn M.

AU - Metspalu, Andres

AU - Stumvoll, Michael

AU - Uitterlinden, Andre G.

AU - Jula, Antti

AU - Navis, Gerjan

AU - Wijmenga, Cisca

AU - Wolffenbuttel, Bruce H. R.

AU - Taskinen, Marja-Riitta

AU - Ala-Korpela, Mika

AU - Kaprio, Jaakko

AU - Kyvik, Kirsten O.

AU - Boomsma, Dorret I.

AU - Pedersen, Nancy L.

AU - Gyllensten, Ulf

AU - Wilson, James F.

AU - Rudan, Igor

AU - Campbell, Harry

AU - Pramstaller, Peter P.

AU - Spector, Tim D.

AU - Witteman, Jacqueline C. M.

AU - Eriksson, Johan G.

AU - Salomaa, Veikko

AU - Oostra, Ben A.

AU - Raitakari, Olli T.

AU - Wichmann, H. -Erich

AU - Gieger, Christian

AU - Jaervelin, Marjo-Riitta

AU - Martin, Nicholas G.

AU - Hofman, Albert

AU - McCarthy, Mark I.

AU - Palotie, Leena

AU - van Duijn, Cornelia M.

AU - Aulchenko, Yurii S.

AU - Ripatti, Samuli

PY - 2011

Y1 - 2011

KW - DENSITY-LIPOPROTEIN CHOLESTEROL

KW - HDL CHOLESTEROL

KW - ASSOCIATION

KW - GENE

KW - SMOKING

KW - PLASMA

KW - TRIGLYCERIDE

KW - OBESITY

KW - LIPIDS

KW - POLYMORPHISMS

KW - 3111 Biomedicine

U2 - 10.1371/journal.pgen.1002333

DO - 10.1371/journal.pgen.1002333

M3 - Article

VL - 7

SP - e1002333

JO - PLoS Genetics

JF - PLoS Genetics

SN - 1553-7390

IS - 10

ER -