A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

Alisa Manning, Heather M. Highland, Jessica Gasser, Xueling Sim, Taru Tukiainen, Pierre Fontanillas, Niels Grarup, Manuel A. Rivas, Anubha Mahajan, Adam E. Locke, Pablo Cingolani, Tune H. Pers, Ana Vinuela, Andrew A. Brown, Ying Wu, Jason Flannick, Christian Fuchsberger, Eric R. Gamazon, Kyle J. Gaulton, Hae Kyung Im & 243 others Tanya M. Teslovich, Thomas W. Blackwell, Jette Bork-Jensen, Noel P. Burtt, Yuhui Chen, Todd Green, Christopher Hartl, Hyun Min Kang, Ashish Kumar, Claes Ladenvall, Clement Ma, Loukas Moutsianas, Richard D. Pearson, John R. B. Perry, N. William Rayner, Neil R. Robertson, Laura J. Scott, Martijn van de Bunt, Johan G. Eriksson, Antti Jula, Seppo Koskinen, Terho Lehtimaki, Aarno Palotie, Olli T. Raitakari, Suzanne B. R. Jacobs, Jennifer Wessel, Audrey Y. Chu, Robert A. Scott, Mark O. Goodarzi, Christine Blancher, Gemma Buck, David Buck, Peter S. Chines, Stacey Gabriel, Anette P. Gjesing, Christopher J. Groves, Mette Hollensted, Jeroen R. Huyghe, Anne U. Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S. Small, Heather M. Stringham, Joseph Trakalo, Eric Banks, Jason Carey, Mauricio O. Carneiro, Mark DePristo, Yossi Farjoun, Timothy Fennell, Jacqueline I. Goldstein, George Grant, Martin Hrabe de Angelis, Jared Maguire, Benjamin M. Neale, Ryan Poplin, Shaun Purcell, Thomas Schwarzmayr, Khalid Shakir, Joshua D. Smith, Tim M. Strom, Thomas Wieland, Jaana Lindstrom, Ivan Brandslund, Cramer Christensen, Gabriela L. Surdulescu, Timo A. Lakka, Alex S. F. Doney, Peter Nilsson, Nicholas J. Wareham, Claudia Langenberg, Tibor V. Varga, Paul W. Franks, Olov Rolandsson, Anders H. Rosengren, Vidya S. Farook, Farook Thameem, Sobha Puppala, Satish Kumar, Donna M. Lehman, Christopher P. Jenkinson, Joanne E. Curran, Daniel Esten Hale, Sharon P. Fowler, Rector Arya, Ralph A. DeFronzo, Hanna E. Abboud, Ann-Christine Syvanen, Pamela J. Hicks, Nicholette D. Palmer, Maggie C. Y. Ng, Donald W. Bowden, Barry I. Freedman, Tonu Esko, Reedik Magi, Lili Milani, Evelin Mihailov, Andres Metspalu, Narisu Narisu, Leena Kinnunen, Lori L. Bonnycastle, Amy Swift, Dorota Pasko, Andrew R. Wood, Joao Fadista, Toni I. Pollin, Nir Barzilai, Gil Atzmon, Benjamin Glaser, Barbara Thorand, Konstantin Strauch, Annette Peters, Michael Roden, Martina Mueller-Nurasyid, Liming Liang, Jennifer Kriebel, Thomas Illig, Harald Grallert, Christian Gieger, Christa Meisinger, Lars Lannfelt, Solomon K. Musani, Michael Griswold, Herman A. Taylor, Gregory Wilson, Adolfo Correa, Heikki Oksa, William R. Scott, Uzma Afzal, Sian-Tsung Tan, Marie Loh, John C. Chambers, Jobanpreet Sehmi, Jaspal Singh Kooner, Benjamin Lehne, Yoon Shin Cho, Jong-Young Lee, Bok-Ghee Han, Annemari Karajamaki, Qibin Qi, Lu Qi, Jinyan Huang, Frank B. Hu, Olle Melander, Marju Orho-Melander, Jennifer E. Below, David Aguilar, Tien Yin Wong, Jianjun Liu, Chiea-Chuen Khor, Kee Seng Chia, Wei Yen Lim, Ching-Yu Cheng, Edmund Chan, E. Shyong Tai, Tin Aung, Allan Linneberg, Bo Isomaa, Thomas Meitinger, Tiinamaija Tuomi, Liisa Hakaste, Jasmina Kravic, Marit E. Jorgensen, Torsten Lauritzen, Panos Deloukas, Kathleen E. Stirrups, Katharine R. Owen, Andrew J. Farmer, Timothy M. Frayling, Stephen P. O'Rahilly, Mark Walker, Jonathan C. Levy, Dylan Hodgkiss, Andrew T. Hattersley, Teemu Kuulasmaa, Alena Stancakova, Ines Barroso, Dwaipayan Bharadwaj, Juliana Chan, Giriraj R. Chandak, Mark J. Daly, Peter J. Donnelly, Shah B. Ebrahim, Paul Elliott, Tasha Fingerlin, Philippe Froguel, Cheng Hu, Weiping Jia, Ronald C. W. Ma, Gilean McVean, Taesung Park, Dorairaj Prabhakaran, Manjinder Sandhu, James Scott, Rob Sladek, Nikhil Tandon, Yik Ying Teo, Eleftheria Zeggini, Richard M. Watanabe, Heikki A. Koistinen, Y. Antero Kesaniemi, Matti Uusitupa, Timothy D. Spector, Veikko Salomaa, Rainer Rauramaa, Colin N. A. Palmer, Inga Prokopenko, Andrew D. Morris, Richard N. Bergman, Francis S. Collins, Lars Lind, Erik Ingelsson, Jaakko Tuomilehto, Fredrik Karpe, Leif Groop, Torben Jorgensen, Torben Hansen, Oluf Pedersen, Johanna Kuusisto, GonOalo Abecasis, Graeme I. Bell, John Blangero, Nancy J. Cox, Ravindranath Duggirala, Mark Seielstad, James G. Wilson, Josee Dupuis, Samuli Ripatti, Craig L. Hanis, Jose C. Florez, Karen L. Mohlke, James B. Meigs, Markku Laakso, Andrew P. Morris, Michael Boehnke, David Altshuler, Mark I. McCarthy, Anna L. Gloyn, Cecilia M. Lindgren

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalDiabetes
Volume66
Issue number7
Pages (from-to)2019-2032
Number of pages14
ISSN0012-1797
DOIs
Publication statusPublished - 1 Jul 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • BETA-CELL MASS
  • NEUROTROPHIC FACTOR
  • GDNF FAMILY
  • GLUCOSE-HOMEOSTASIS
  • FATTY RAT
  • ZDF RATS
  • EXPRESSION
  • SECRETION
  • NEURTURIN
  • MELLITUS
  • 3121 Internal medicine

Cite this

Manning, Alisa ; Highland, Heather M. ; Gasser, Jessica ; Sim, Xueling ; Tukiainen, Taru ; Fontanillas, Pierre ; Grarup, Niels ; Rivas, Manuel A. ; Mahajan, Anubha ; Locke, Adam E. ; Cingolani, Pablo ; Pers, Tune H. ; Vinuela, Ana ; Brown, Andrew A. ; Wu, Ying ; Flannick, Jason ; Fuchsberger, Christian ; Gamazon, Eric R. ; Gaulton, Kyle J. ; Im, Hae Kyung ; Teslovich, Tanya M. ; Blackwell, Thomas W. ; Bork-Jensen, Jette ; Burtt, Noel P. ; Chen, Yuhui ; Green, Todd ; Hartl, Christopher ; Kang, Hyun Min ; Kumar, Ashish ; Ladenvall, Claes ; Ma, Clement ; Moutsianas, Loukas ; Pearson, Richard D. ; Perry, John R. B. ; Rayner, N. William ; Robertson, Neil R. ; Scott, Laura J. ; van de Bunt, Martijn ; Eriksson, Johan G. ; Jula, Antti ; Koskinen, Seppo ; Lehtimaki, Terho ; Palotie, Aarno ; Raitakari, Olli T. ; Jacobs, Suzanne B. R. ; Wessel, Jennifer ; Chu, Audrey Y. ; Scott, Robert A. ; Goodarzi, Mark O. ; Blancher, Christine ; Buck, Gemma ; Buck, David ; Chines, Peter S. ; Gabriel, Stacey ; Gjesing, Anette P. ; Groves, Christopher J. ; Hollensted, Mette ; Huyghe, Jeroen R. ; Jackson, Anne U. ; Jun, Goo ; Justesen, Johanne Marie ; Mangino, Massimo ; Murphy, Jacquelyn ; Neville, Matt ; Onofrio, Robert ; Small, Kerrin S. ; Stringham, Heather M. ; Trakalo, Joseph ; Banks, Eric ; Carey, Jason ; Carneiro, Mauricio O. ; DePristo, Mark ; Farjoun, Yossi ; Fennell, Timothy ; Goldstein, Jacqueline I. ; Grant, George ; de Angelis, Martin Hrabe ; Maguire, Jared ; Neale, Benjamin M. ; Poplin, Ryan ; Purcell, Shaun ; Schwarzmayr, Thomas ; Shakir, Khalid ; Smith, Joshua D. ; Strom, Tim M. ; Wieland, Thomas ; Lindstrom, Jaana ; Brandslund, Ivan ; Christensen, Cramer ; Surdulescu, Gabriela L. ; Lakka, Timo A. ; Doney, Alex S. F. ; Nilsson, Peter ; Wareham, Nicholas J. ; Langenberg, Claudia ; Varga, Tibor V. ; Franks, Paul W. ; Rolandsson, Olov ; Rosengren, Anders H. ; Farook, Vidya S. ; Thameem, Farook ; Puppala, Sobha ; Kumar, Satish ; Lehman, Donna M. ; Jenkinson, Christopher P. ; Curran, Joanne E. ; Hale, Daniel Esten ; Fowler, Sharon P. ; Arya, Rector ; DeFronzo, Ralph A. ; Abboud, Hanna E. ; Syvanen, Ann-Christine ; Hicks, Pamela J. ; Palmer, Nicholette D. ; Ng, Maggie C. Y. ; Bowden, Donald W. ; Freedman, Barry I. ; Esko, Tonu ; Magi, Reedik ; Milani, Lili ; Mihailov, Evelin ; Metspalu, Andres ; Narisu, Narisu ; Kinnunen, Leena ; Bonnycastle, Lori L. ; Swift, Amy ; Pasko, Dorota ; Wood, Andrew R. ; Fadista, Joao ; Pollin, Toni I. ; Barzilai, Nir ; Atzmon, Gil ; Glaser, Benjamin ; Thorand, Barbara ; Strauch, Konstantin ; Peters, Annette ; Roden, Michael ; Mueller-Nurasyid, Martina ; Liang, Liming ; Kriebel, Jennifer ; Illig, Thomas ; Grallert, Harald ; Gieger, Christian ; Meisinger, Christa ; Lannfelt, Lars ; Musani, Solomon K. ; Griswold, Michael ; Taylor, Herman A. ; Wilson, Gregory ; Correa, Adolfo ; Oksa, Heikki ; Scott, William R. ; Afzal, Uzma ; Tan, Sian-Tsung ; Loh, Marie ; Chambers, John C. ; Sehmi, Jobanpreet ; Kooner, Jaspal Singh ; Lehne, Benjamin ; Cho, Yoon Shin ; Lee, Jong-Young ; Han, Bok-Ghee ; Karajamaki, Annemari ; Qi, Qibin ; Qi, Lu ; Huang, Jinyan ; Hu, Frank B. ; Melander, Olle ; Orho-Melander, Marju ; Below, Jennifer E. ; Aguilar, David ; Wong, Tien Yin ; Liu, Jianjun ; Khor, Chiea-Chuen ; Chia, Kee Seng ; Lim, Wei Yen ; Cheng, Ching-Yu ; Chan, Edmund ; Tai, E. Shyong ; Aung, Tin ; Linneberg, Allan ; Isomaa, Bo ; Meitinger, Thomas ; Tuomi, Tiinamaija ; Hakaste, Liisa ; Kravic, Jasmina ; Jorgensen, Marit E. ; Lauritzen, Torsten ; Deloukas, Panos ; Stirrups, Kathleen E. ; Owen, Katharine R. ; Farmer, Andrew J. ; Frayling, Timothy M. ; O'Rahilly, Stephen P. ; Walker, Mark ; Levy, Jonathan C. ; Hodgkiss, Dylan ; Hattersley, Andrew T. ; Kuulasmaa, Teemu ; Stancakova, Alena ; Barroso, Ines ; Bharadwaj, Dwaipayan ; Chan, Juliana ; Chandak, Giriraj R. ; Daly, Mark J. ; Donnelly, Peter J. ; Ebrahim, Shah B. ; Elliott, Paul ; Fingerlin, Tasha ; Froguel, Philippe ; Hu, Cheng ; Jia, Weiping ; Ma, Ronald C. W. ; McVean, Gilean ; Park, Taesung ; Prabhakaran, Dorairaj ; Sandhu, Manjinder ; Scott, James ; Sladek, Rob ; Tandon, Nikhil ; Teo, Yik Ying ; Zeggini, Eleftheria ; Watanabe, Richard M. ; Koistinen, Heikki A. ; Kesaniemi, Y. Antero ; Uusitupa, Matti ; Spector, Timothy D. ; Salomaa, Veikko ; Rauramaa, Rainer ; Palmer, Colin N. A. ; Prokopenko, Inga ; Morris, Andrew D. ; Bergman, Richard N. ; Collins, Francis S. ; Lind, Lars ; Ingelsson, Erik ; Tuomilehto, Jaakko ; Karpe, Fredrik ; Groop, Leif ; Jorgensen, Torben ; Hansen, Torben ; Pedersen, Oluf ; Kuusisto, Johanna ; Abecasis, GonOalo ; Bell, Graeme I. ; Blangero, John ; Cox, Nancy J. ; Duggirala, Ravindranath ; Seielstad, Mark ; Wilson, James G. ; Dupuis, Josee ; Ripatti, Samuli ; Hanis, Craig L. ; Florez, Jose C. ; Mohlke, Karen L. ; Meigs, James B. ; Laakso, Markku ; Morris, Andrew P. ; Boehnke, Michael ; Altshuler, David ; McCarthy, Mark I. ; Gloyn, Anna L. ; Lindgren, Cecilia M. / A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. In: Diabetes. 2017 ; Vol. 66, No. 7. pp. 2019-2032.
@article{49f43a510f41416f873debd13032bdd1,
title = "A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk",
keywords = "BETA-CELL MASS, NEUROTROPHIC FACTOR, GDNF FAMILY, GLUCOSE-HOMEOSTASIS, FATTY RAT, ZDF RATS, EXPRESSION, SECRETION, NEURTURIN, MELLITUS, 3121 Internal medicine",
author = "Alisa Manning and Highland, {Heather M.} and Jessica Gasser and Xueling Sim and Taru Tukiainen and Pierre Fontanillas and Niels Grarup and Rivas, {Manuel A.} and Anubha Mahajan and Locke, {Adam E.} and Pablo Cingolani and Pers, {Tune H.} and Ana Vinuela and Brown, {Andrew A.} and Ying Wu and Jason Flannick and Christian Fuchsberger and Gamazon, {Eric R.} and Gaulton, {Kyle J.} and Im, {Hae Kyung} and Teslovich, {Tanya M.} and Blackwell, {Thomas W.} and Jette Bork-Jensen and Burtt, {Noel P.} and Yuhui Chen and Todd Green and Christopher Hartl and Kang, {Hyun Min} and Ashish Kumar and Claes Ladenvall and Clement Ma and Loukas Moutsianas and Pearson, {Richard D.} and Perry, {John R. B.} and Rayner, {N. William} and Robertson, {Neil R.} and Scott, {Laura J.} and {van de Bunt}, Martijn and Eriksson, {Johan G.} and Antti Jula and Seppo Koskinen and Terho Lehtimaki and Aarno Palotie and Raitakari, {Olli T.} and Jacobs, {Suzanne B. R.} and Jennifer Wessel and Chu, {Audrey Y.} and Scott, {Robert A.} and Goodarzi, {Mark O.} and Christine Blancher and Gemma Buck and David Buck and Chines, {Peter S.} and Stacey Gabriel and Gjesing, {Anette P.} and Groves, {Christopher J.} and Mette Hollensted and Huyghe, {Jeroen R.} and Jackson, {Anne U.} and Goo Jun and Justesen, {Johanne Marie} and Massimo Mangino and Jacquelyn Murphy and Matt Neville and Robert Onofrio and Small, {Kerrin S.} and Stringham, {Heather M.} and Joseph Trakalo and Eric Banks and Jason Carey and Carneiro, {Mauricio O.} and Mark DePristo and Yossi Farjoun and Timothy Fennell and Goldstein, {Jacqueline I.} and George Grant and {de Angelis}, {Martin Hrabe} and Jared Maguire and Neale, {Benjamin M.} and Ryan Poplin and Shaun Purcell and Thomas Schwarzmayr and Khalid Shakir and Smith, {Joshua D.} and Strom, {Tim M.} and Thomas Wieland and Jaana Lindstrom and Ivan Brandslund and Cramer Christensen and Surdulescu, {Gabriela L.} and Lakka, {Timo A.} and Doney, {Alex S. F.} and Peter Nilsson and Wareham, {Nicholas J.} and Claudia Langenberg and Varga, {Tibor V.} and Franks, {Paul W.} and Olov Rolandsson and Rosengren, {Anders H.} and Farook, {Vidya S.} and Farook Thameem and Sobha Puppala and Satish Kumar and Lehman, {Donna M.} and Jenkinson, {Christopher P.} and Curran, {Joanne E.} and Hale, {Daniel Esten} and Fowler, {Sharon P.} and Rector Arya and DeFronzo, {Ralph A.} and Abboud, {Hanna E.} and Ann-Christine Syvanen and Hicks, {Pamela J.} and Palmer, {Nicholette D.} and Ng, {Maggie C. Y.} and Bowden, {Donald W.} and Freedman, {Barry I.} and Tonu Esko and Reedik Magi and Lili Milani and Evelin Mihailov and Andres Metspalu and Narisu Narisu and Leena Kinnunen and Bonnycastle, {Lori L.} and Amy Swift and Dorota Pasko and Wood, {Andrew R.} and Joao Fadista and Pollin, {Toni I.} and Nir Barzilai and Gil Atzmon and Benjamin Glaser and Barbara Thorand and Konstantin Strauch and Annette Peters and Michael Roden and Martina Mueller-Nurasyid and Liming Liang and Jennifer Kriebel and Thomas Illig and Harald Grallert and Christian Gieger and Christa Meisinger and Lars Lannfelt and Musani, {Solomon K.} and Michael Griswold and Taylor, {Herman A.} and Gregory Wilson and Adolfo Correa and Heikki Oksa and Scott, {William R.} and Uzma Afzal and Sian-Tsung Tan and Marie Loh and Chambers, {John C.} and Jobanpreet Sehmi and Kooner, {Jaspal Singh} and Benjamin Lehne and Cho, {Yoon Shin} and Jong-Young Lee and Bok-Ghee Han and Annemari Karajamaki and Qibin Qi and Lu Qi and Jinyan Huang and Hu, {Frank B.} and Olle Melander and Marju Orho-Melander and Below, {Jennifer E.} and David Aguilar and Wong, {Tien Yin} and Jianjun Liu and Chiea-Chuen Khor and Chia, {Kee Seng} and Lim, {Wei Yen} and Ching-Yu Cheng and Edmund Chan and Tai, {E. Shyong} and Tin Aung and Allan Linneberg and Bo Isomaa and Thomas Meitinger and Tiinamaija Tuomi and Liisa Hakaste and Jasmina Kravic and Jorgensen, {Marit E.} and Torsten Lauritzen and Panos Deloukas and Stirrups, {Kathleen E.} and Owen, {Katharine R.} and Farmer, {Andrew J.} and Frayling, {Timothy M.} and O'Rahilly, {Stephen P.} and Mark Walker and Levy, {Jonathan C.} and Dylan Hodgkiss and Hattersley, {Andrew T.} and Teemu Kuulasmaa and Alena Stancakova and Ines Barroso and Dwaipayan Bharadwaj and Juliana Chan and Chandak, {Giriraj R.} and Daly, {Mark J.} and Donnelly, {Peter J.} and Ebrahim, {Shah B.} and Paul Elliott and Tasha Fingerlin and Philippe Froguel and Cheng Hu and Weiping Jia and Ma, {Ronald C. W.} and Gilean McVean and Taesung Park and Dorairaj Prabhakaran and Manjinder Sandhu and James Scott and Rob Sladek and Nikhil Tandon and Teo, {Yik Ying} and Eleftheria Zeggini and Watanabe, {Richard M.} and Koistinen, {Heikki A.} and Kesaniemi, {Y. Antero} and Matti Uusitupa and Spector, {Timothy D.} and Veikko Salomaa and Rainer Rauramaa and Palmer, {Colin N. A.} and Inga Prokopenko and Morris, {Andrew D.} and Bergman, {Richard N.} and Collins, {Francis S.} and Lars Lind and Erik Ingelsson and Jaakko Tuomilehto and Fredrik Karpe and Leif Groop and Torben Jorgensen and Torben Hansen and Oluf Pedersen and Johanna Kuusisto and GonOalo Abecasis and Bell, {Graeme I.} and John Blangero and Cox, {Nancy J.} and Ravindranath Duggirala and Mark Seielstad and Wilson, {James G.} and Josee Dupuis and Samuli Ripatti and Hanis, {Craig L.} and Florez, {Jose C.} and Mohlke, {Karen L.} and Meigs, {James B.} and Markku Laakso and Morris, {Andrew P.} and Michael Boehnke and David Altshuler and McCarthy, {Mark I.} and Gloyn, {Anna L.} and Lindgren, {Cecilia M.}",
year = "2017",
month = "7",
day = "1",
doi = "10.2337/db16-1329",
language = "English",
volume = "66",
pages = "2019--2032",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "7",

}

Manning, A, Highland, HM, Gasser, J, Sim, X, Tukiainen, T, Fontanillas, P, Grarup, N, Rivas, MA, Mahajan, A, Locke, AE, Cingolani, P, Pers, TH, Vinuela, A, Brown, AA, Wu, Y, Flannick, J, Fuchsberger, C, Gamazon, ER, Gaulton, KJ, Im, HK, Teslovich, TM, Blackwell, TW, Bork-Jensen, J, Burtt, NP, Chen, Y, Green, T, Hartl, C, Kang, HM, Kumar, A, Ladenvall, C, Ma, C, Moutsianas, L, Pearson, RD, Perry, JRB, Rayner, NW, Robertson, NR, Scott, LJ, van de Bunt, M, Eriksson, JG, Jula, A, Koskinen, S, Lehtimaki, T, Palotie, A, Raitakari, OT, Jacobs, SBR, Wessel, J, Chu, AY, Scott, RA, Goodarzi, MO, Blancher, C, Buck, G, Buck, D, Chines, PS, Gabriel, S, Gjesing, AP, Groves, CJ, Hollensted, M, Huyghe, JR, Jackson, AU, Jun, G, Justesen, JM, Mangino, M, Murphy, J, Neville, M, Onofrio, R, Small, KS, Stringham, HM, Trakalo, J, Banks, E, Carey, J, Carneiro, MO, DePristo, M, Farjoun, Y, Fennell, T, Goldstein, JI, Grant, G, de Angelis, MH, Maguire, J, Neale, BM, Poplin, R, Purcell, S, Schwarzmayr, T, Shakir, K, Smith, JD, Strom, TM, Wieland, T, Lindstrom, J, Brandslund, I, Christensen, C, Surdulescu, GL, Lakka, TA, Doney, ASF, Nilsson, P, Wareham, NJ, Langenberg, C, Varga, TV, Franks, PW, Rolandsson, O, Rosengren, AH, Farook, VS, Thameem, F, Puppala, S, Kumar, S, Lehman, DM, Jenkinson, CP, Curran, JE, Hale, DE, Fowler, SP, Arya, R, DeFronzo, RA, Abboud, HE, Syvanen, A-C, Hicks, PJ, Palmer, ND, Ng, MCY, Bowden, DW, Freedman, BI, Esko, T, Magi, R, Milani, L, Mihailov, E, Metspalu, A, Narisu, N, Kinnunen, L, Bonnycastle, LL, Swift, A, Pasko, D, Wood, AR, Fadista, J, Pollin, TI, Barzilai, N, Atzmon, G, Glaser, B, Thorand, B, Strauch, K, Peters, A, Roden, M, Mueller-Nurasyid, M, Liang, L, Kriebel, J, Illig, T, Grallert, H, Gieger, C, Meisinger, C, Lannfelt, L, Musani, SK, Griswold, M, Taylor, HA, Wilson, G, Correa, A, Oksa, H, Scott, WR, Afzal, U, Tan, S-T, Loh, M, Chambers, JC, Sehmi, J, Kooner, JS, Lehne, B, Cho, YS, Lee, J-Y, Han, B-G, Karajamaki, A, Qi, Q, Qi, L, Huang, J, Hu, FB, Melander, O, Orho-Melander, M, Below, JE, Aguilar, D, Wong, TY, Liu, J, Khor, C-C, Chia, KS, Lim, WY, Cheng, C-Y, Chan, E, Tai, ES, Aung, T, Linneberg, A, Isomaa, B, Meitinger, T, Tuomi, T, Hakaste, L, Kravic, J, Jorgensen, ME, Lauritzen, T, Deloukas, P, Stirrups, KE, Owen, KR, Farmer, AJ, Frayling, TM, O'Rahilly, SP, Walker, M, Levy, JC, Hodgkiss, D, Hattersley, AT, Kuulasmaa, T, Stancakova, A, Barroso, I, Bharadwaj, D, Chan, J, Chandak, GR, Daly, MJ, Donnelly, PJ, Ebrahim, SB, Elliott, P, Fingerlin, T, Froguel, P, Hu, C, Jia, W, Ma, RCW, McVean, G, Park, T, Prabhakaran, D, Sandhu, M, Scott, J, Sladek, R, Tandon, N, Teo, YY, Zeggini, E, Watanabe, RM, Koistinen, HA, Kesaniemi, YA, Uusitupa, M, Spector, TD, Salomaa, V, Rauramaa, R, Palmer, CNA, Prokopenko, I, Morris, AD, Bergman, RN, Collins, FS, Lind, L, Ingelsson, E, Tuomilehto, J, Karpe, F, Groop, L, Jorgensen, T, Hansen, T, Pedersen, O, Kuusisto, J, Abecasis, G, Bell, GI, Blangero, J, Cox, NJ, Duggirala, R, Seielstad, M, Wilson, JG, Dupuis, J, Ripatti, S, Hanis, CL, Florez, JC, Mohlke, KL, Meigs, JB, Laakso, M, Morris, AP, Boehnke, M, Altshuler, D, McCarthy, MI, Gloyn, AL & Lindgren, CM 2017, 'A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk', Diabetes, vol. 66, no. 7, pp. 2019-2032. https://doi.org/10.2337/db16-1329

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. / Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A.; Mahajan, Anubha; Locke, Adam E.; Cingolani, Pablo; Pers, Tune H.; Vinuela, Ana; Brown, Andrew A.; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R.; Gaulton, Kyle J.; Im, Hae Kyung; Teslovich, Tanya M.; Blackwell, Thomas W.; Bork-Jensen, Jette; Burtt, Noel P.; Chen, Yuhui; Green, Todd; Hartl, Christopher; Kang, Hyun Min; Kumar, Ashish; Ladenvall, Claes; Ma, Clement; Moutsianas, Loukas; Pearson, Richard D.; Perry, John R. B.; Rayner, N. William; Robertson, Neil R.; Scott, Laura J.; van de Bunt, Martijn; Eriksson, Johan G.; Jula, Antti; Koskinen, Seppo; Lehtimaki, Terho; Palotie, Aarno; Raitakari, Olli T.; Jacobs, Suzanne B. R.; Wessel, Jennifer; Chu, Audrey Y.; Scott, Robert A.; Goodarzi, Mark O.; Blancher, Christine; Buck, Gemma; Buck, David; Chines, Peter S.; Gabriel, Stacey; Gjesing, Anette P.; Groves, Christopher J.; Hollensted, Mette; Huyghe, Jeroen R.; Jackson, Anne U.; Jun, Goo; Justesen, Johanne Marie; Mangino, Massimo; Murphy, Jacquelyn; Neville, Matt; Onofrio, Robert; Small, Kerrin S.; Stringham, Heather M.; Trakalo, Joseph; Banks, Eric; Carey, Jason; Carneiro, Mauricio O.; DePristo, Mark; Farjoun, Yossi; Fennell, Timothy; Goldstein, Jacqueline I.; Grant, George; de Angelis, Martin Hrabe; Maguire, Jared; Neale, Benjamin M.; Poplin, Ryan; Purcell, Shaun; Schwarzmayr, Thomas; Shakir, Khalid; Smith, Joshua D.; Strom, Tim M.; Wieland, Thomas; Lindstrom, Jaana; Brandslund, Ivan; Christensen, Cramer; Surdulescu, Gabriela L.; Lakka, Timo A.; Doney, Alex S. F.; Nilsson, Peter; Wareham, Nicholas J.; Langenberg, Claudia; Varga, Tibor V.; Franks, Paul W.; Rolandsson, Olov; Rosengren, Anders H.; Farook, Vidya S.; Thameem, Farook; Puppala, Sobha; Kumar, Satish; Lehman, Donna M.; Jenkinson, Christopher P.; Curran, Joanne E.; Hale, Daniel Esten; Fowler, Sharon P.; Arya, Rector; DeFronzo, Ralph A.; Abboud, Hanna E.; Syvanen, Ann-Christine; Hicks, Pamela J.; Palmer, Nicholette D.; Ng, Maggie C. Y.; Bowden, Donald W.; Freedman, Barry I.; Esko, Tonu; Magi, Reedik; Milani, Lili; Mihailov, Evelin; Metspalu, Andres; Narisu, Narisu; Kinnunen, Leena; Bonnycastle, Lori L.; Swift, Amy; Pasko, Dorota; Wood, Andrew R.; Fadista, Joao; Pollin, Toni I.; Barzilai, Nir; Atzmon, Gil; Glaser, Benjamin; Thorand, Barbara; Strauch, Konstantin; Peters, Annette; Roden, Michael; Mueller-Nurasyid, Martina; Liang, Liming; Kriebel, Jennifer; Illig, Thomas; Grallert, Harald; Gieger, Christian; Meisinger, Christa; Lannfelt, Lars; Musani, Solomon K.; Griswold, Michael; Taylor, Herman A.; Wilson, Gregory; Correa, Adolfo; Oksa, Heikki; Scott, William R.; Afzal, Uzma; Tan, Sian-Tsung; Loh, Marie; Chambers, John C.; Sehmi, Jobanpreet; Kooner, Jaspal Singh; Lehne, Benjamin; Cho, Yoon Shin; Lee, Jong-Young; Han, Bok-Ghee; Karajamaki, Annemari; Qi, Qibin; Qi, Lu; Huang, Jinyan; Hu, Frank B.; Melander, Olle; Orho-Melander, Marju; Below, Jennifer E.; Aguilar, David; Wong, Tien Yin; Liu, Jianjun; Khor, Chiea-Chuen; Chia, Kee Seng; Lim, Wei Yen; Cheng, Ching-Yu; Chan, Edmund; Tai, E. Shyong; Aung, Tin; Linneberg, Allan; Isomaa, Bo; Meitinger, Thomas; Tuomi, Tiinamaija; Hakaste, Liisa; Kravic, Jasmina; Jorgensen, Marit E.; Lauritzen, Torsten; Deloukas, Panos; Stirrups, Kathleen E.; Owen, Katharine R.; Farmer, Andrew J.; Frayling, Timothy M.; O'Rahilly, Stephen P.; Walker, Mark; Levy, Jonathan C.; Hodgkiss, Dylan; Hattersley, Andrew T.; Kuulasmaa, Teemu; Stancakova, Alena; Barroso, Ines; Bharadwaj, Dwaipayan; Chan, Juliana; Chandak, Giriraj R.; Daly, Mark J.; Donnelly, Peter J.; Ebrahim, Shah B.; Elliott, Paul; Fingerlin, Tasha; Froguel, Philippe; Hu, Cheng; Jia, Weiping; Ma, Ronald C. W.; McVean, Gilean; Park, Taesung; Prabhakaran, Dorairaj; Sandhu, Manjinder; Scott, James; Sladek, Rob; Tandon, Nikhil; Teo, Yik Ying; Zeggini, Eleftheria; Watanabe, Richard M.; Koistinen, Heikki A.; Kesaniemi, Y. Antero; Uusitupa, Matti; Spector, Timothy D.; Salomaa, Veikko; Rauramaa, Rainer; Palmer, Colin N. A.; Prokopenko, Inga; Morris, Andrew D.; Bergman, Richard N.; Collins, Francis S.; Lind, Lars; Ingelsson, Erik; Tuomilehto, Jaakko; Karpe, Fredrik; Groop, Leif; Jorgensen, Torben; Hansen, Torben; Pedersen, Oluf; Kuusisto, Johanna; Abecasis, GonOalo; Bell, Graeme I.; Blangero, John; Cox, Nancy J.; Duggirala, Ravindranath; Seielstad, Mark; Wilson, James G.; Dupuis, Josee; Ripatti, Samuli; Hanis, Craig L.; Florez, Jose C.; Mohlke, Karen L.; Meigs, James B.; Laakso, Markku; Morris, Andrew P.; Boehnke, Michael; Altshuler, David; McCarthy, Mark I.; Gloyn, Anna L.; Lindgren, Cecilia M.

In: Diabetes, Vol. 66, No. 7, 01.07.2017, p. 2019-2032.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

AU - Manning, Alisa

AU - Highland, Heather M.

AU - Gasser, Jessica

AU - Sim, Xueling

AU - Tukiainen, Taru

AU - Fontanillas, Pierre

AU - Grarup, Niels

AU - Rivas, Manuel A.

AU - Mahajan, Anubha

AU - Locke, Adam E.

AU - Cingolani, Pablo

AU - Pers, Tune H.

AU - Vinuela, Ana

AU - Brown, Andrew A.

AU - Wu, Ying

AU - Flannick, Jason

AU - Fuchsberger, Christian

AU - Gamazon, Eric R.

AU - Gaulton, Kyle J.

AU - Im, Hae Kyung

AU - Teslovich, Tanya M.

AU - Blackwell, Thomas W.

AU - Bork-Jensen, Jette

AU - Burtt, Noel P.

AU - Chen, Yuhui

AU - Green, Todd

AU - Hartl, Christopher

AU - Kang, Hyun Min

AU - Kumar, Ashish

AU - Ladenvall, Claes

AU - Ma, Clement

AU - Moutsianas, Loukas

AU - Pearson, Richard D.

AU - Perry, John R. B.

AU - Rayner, N. William

AU - Robertson, Neil R.

AU - Scott, Laura J.

AU - van de Bunt, Martijn

AU - Eriksson, Johan G.

AU - Jula, Antti

AU - Koskinen, Seppo

AU - Lehtimaki, Terho

AU - Palotie, Aarno

AU - Raitakari, Olli T.

AU - Jacobs, Suzanne B. R.

AU - Wessel, Jennifer

AU - Chu, Audrey Y.

AU - Scott, Robert A.

AU - Goodarzi, Mark O.

AU - Blancher, Christine

AU - Buck, Gemma

AU - Buck, David

AU - Chines, Peter S.

AU - Gabriel, Stacey

AU - Gjesing, Anette P.

AU - Groves, Christopher J.

AU - Hollensted, Mette

AU - Huyghe, Jeroen R.

AU - Jackson, Anne U.

AU - Jun, Goo

AU - Justesen, Johanne Marie

AU - Mangino, Massimo

AU - Murphy, Jacquelyn

AU - Neville, Matt

AU - Onofrio, Robert

AU - Small, Kerrin S.

AU - Stringham, Heather M.

AU - Trakalo, Joseph

AU - Banks, Eric

AU - Carey, Jason

AU - Carneiro, Mauricio O.

AU - DePristo, Mark

AU - Farjoun, Yossi

AU - Fennell, Timothy

AU - Goldstein, Jacqueline I.

AU - Grant, George

AU - de Angelis, Martin Hrabe

AU - Maguire, Jared

AU - Neale, Benjamin M.

AU - Poplin, Ryan

AU - Purcell, Shaun

AU - Schwarzmayr, Thomas

AU - Shakir, Khalid

AU - Smith, Joshua D.

AU - Strom, Tim M.

AU - Wieland, Thomas

AU - Lindstrom, Jaana

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Surdulescu, Gabriela L.

AU - Lakka, Timo A.

AU - Doney, Alex S. F.

AU - Nilsson, Peter

AU - Wareham, Nicholas J.

AU - Langenberg, Claudia

AU - Varga, Tibor V.

AU - Franks, Paul W.

AU - Rolandsson, Olov

AU - Rosengren, Anders H.

AU - Farook, Vidya S.

AU - Thameem, Farook

AU - Puppala, Sobha

AU - Kumar, Satish

AU - Lehman, Donna M.

AU - Jenkinson, Christopher P.

AU - Curran, Joanne E.

AU - Hale, Daniel Esten

AU - Fowler, Sharon P.

AU - Arya, Rector

AU - DeFronzo, Ralph A.

AU - Abboud, Hanna E.

AU - Syvanen, Ann-Christine

AU - Hicks, Pamela J.

AU - Palmer, Nicholette D.

AU - Ng, Maggie C. Y.

AU - Bowden, Donald W.

AU - Freedman, Barry I.

AU - Esko, Tonu

AU - Magi, Reedik

AU - Milani, Lili

AU - Mihailov, Evelin

AU - Metspalu, Andres

AU - Narisu, Narisu

AU - Kinnunen, Leena

AU - Bonnycastle, Lori L.

AU - Swift, Amy

AU - Pasko, Dorota

AU - Wood, Andrew R.

AU - Fadista, Joao

AU - Pollin, Toni I.

AU - Barzilai, Nir

AU - Atzmon, Gil

AU - Glaser, Benjamin

AU - Thorand, Barbara

AU - Strauch, Konstantin

AU - Peters, Annette

AU - Roden, Michael

AU - Mueller-Nurasyid, Martina

AU - Liang, Liming

AU - Kriebel, Jennifer

AU - Illig, Thomas

AU - Grallert, Harald

AU - Gieger, Christian

AU - Meisinger, Christa

AU - Lannfelt, Lars

AU - Musani, Solomon K.

AU - Griswold, Michael

AU - Taylor, Herman A.

AU - Wilson, Gregory

AU - Correa, Adolfo

AU - Oksa, Heikki

AU - Scott, William R.

AU - Afzal, Uzma

AU - Tan, Sian-Tsung

AU - Loh, Marie

AU - Chambers, John C.

AU - Sehmi, Jobanpreet

AU - Kooner, Jaspal Singh

AU - Lehne, Benjamin

AU - Cho, Yoon Shin

AU - Lee, Jong-Young

AU - Han, Bok-Ghee

AU - Karajamaki, Annemari

AU - Qi, Qibin

AU - Qi, Lu

AU - Huang, Jinyan

AU - Hu, Frank B.

AU - Melander, Olle

AU - Orho-Melander, Marju

AU - Below, Jennifer E.

AU - Aguilar, David

AU - Wong, Tien Yin

AU - Liu, Jianjun

AU - Khor, Chiea-Chuen

AU - Chia, Kee Seng

AU - Lim, Wei Yen

AU - Cheng, Ching-Yu

AU - Chan, Edmund

AU - Tai, E. Shyong

AU - Aung, Tin

AU - Linneberg, Allan

AU - Isomaa, Bo

AU - Meitinger, Thomas

AU - Tuomi, Tiinamaija

AU - Hakaste, Liisa

AU - Kravic, Jasmina

AU - Jorgensen, Marit E.

AU - Lauritzen, Torsten

AU - Deloukas, Panos

AU - Stirrups, Kathleen E.

AU - Owen, Katharine R.

AU - Farmer, Andrew J.

AU - Frayling, Timothy M.

AU - O'Rahilly, Stephen P.

AU - Walker, Mark

AU - Levy, Jonathan C.

AU - Hodgkiss, Dylan

AU - Hattersley, Andrew T.

AU - Kuulasmaa, Teemu

AU - Stancakova, Alena

AU - Barroso, Ines

AU - Bharadwaj, Dwaipayan

AU - Chan, Juliana

AU - Chandak, Giriraj R.

AU - Daly, Mark J.

AU - Donnelly, Peter J.

AU - Ebrahim, Shah B.

AU - Elliott, Paul

AU - Fingerlin, Tasha

AU - Froguel, Philippe

AU - Hu, Cheng

AU - Jia, Weiping

AU - Ma, Ronald C. W.

AU - McVean, Gilean

AU - Park, Taesung

AU - Prabhakaran, Dorairaj

AU - Sandhu, Manjinder

AU - Scott, James

AU - Sladek, Rob

AU - Tandon, Nikhil

AU - Teo, Yik Ying

AU - Zeggini, Eleftheria

AU - Watanabe, Richard M.

AU - Koistinen, Heikki A.

AU - Kesaniemi, Y. Antero

AU - Uusitupa, Matti

AU - Spector, Timothy D.

AU - Salomaa, Veikko

AU - Rauramaa, Rainer

AU - Palmer, Colin N. A.

AU - Prokopenko, Inga

AU - Morris, Andrew D.

AU - Bergman, Richard N.

AU - Collins, Francis S.

AU - Lind, Lars

AU - Ingelsson, Erik

AU - Tuomilehto, Jaakko

AU - Karpe, Fredrik

AU - Groop, Leif

AU - Jorgensen, Torben

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Kuusisto, Johanna

AU - Abecasis, GonOalo

AU - Bell, Graeme I.

AU - Blangero, John

AU - Cox, Nancy J.

AU - Duggirala, Ravindranath

AU - Seielstad, Mark

AU - Wilson, James G.

AU - Dupuis, Josee

AU - Ripatti, Samuli

AU - Hanis, Craig L.

AU - Florez, Jose C.

AU - Mohlke, Karen L.

AU - Meigs, James B.

AU - Laakso, Markku

AU - Morris, Andrew P.

AU - Boehnke, Michael

AU - Altshuler, David

AU - McCarthy, Mark I.

AU - Gloyn, Anna L.

AU - Lindgren, Cecilia M.

PY - 2017/7/1

Y1 - 2017/7/1

KW - BETA-CELL MASS

KW - NEUROTROPHIC FACTOR

KW - GDNF FAMILY

KW - GLUCOSE-HOMEOSTASIS

KW - FATTY RAT

KW - ZDF RATS

KW - EXPRESSION

KW - SECRETION

KW - NEURTURIN

KW - MELLITUS

KW - 3121 Internal medicine

U2 - 10.2337/db16-1329

DO - 10.2337/db16-1329

M3 - Article

VL - 66

SP - 2019

EP - 2032

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 7

ER -