A migration-associated supergene reveals loss of biocomplexity in Atlantic cod

Tony Kess, Paul Bentzen, Sarah J. Lehnert, Emma V.A. Sylvester, Sigbjorn Lien, Matthew P. Kent, Marion Sinclair-Waters, Corey J. Morris, Paul Regular, Robert Fairweather, Ian R. Bradbury

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Chromosome structural variation may underpin ecologically important intraspecific diversity by reducing recombination within supergenes containing linked, coadapted alleles. Here, we confirm that an ancient chromosomal rearrangement is strongly associated with migratory phenotype and individual genetic structure in Atlantic cod (Gadus morhua) across the Northwest Atlantic. We reconstruct trends in effective population size over the last century and reveal declines in effective population size matching onset of industrialized harvest (after 1950). We find different demographic trajectories between individuals homozygous for the chromosomal rearrangement relative to heterozygous or homozygous individuals for the noninverted haplotype, suggesting different selective histories across the past 150 years. These results illustrate how chromosomal structural diversity can mediate fine-scale genetic, phenotypic, and demographic variation in a highly connected marine species and show how overfishing may have led to loss of biocomplexity within Northern cod stock.

Original languageEnglish
Article number2461
JournalScience Advances
Volume5
Issue number6
Number of pages8
ISSN2375-2548
DOIs
Publication statusPublished - 26 Jun 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 1184 Genetics, developmental biology, physiology
  • EFFECTIVE POPULATION-SIZE
  • LINKAGE DISEQUILIBRIUM
  • SELECTIVE SWEEPS
  • GADUS-MORHUA
  • R PACKAGE
  • EVOLUTION
  • INVERSIONS
  • DIVERGENCE
  • SCANS
  • CONSEQUENCES

Cite this

Kess, T., Bentzen, P., Lehnert, S. J., Sylvester, E. V. A., Lien, S., Kent, M. P., ... Bradbury, I. R. (2019). A migration-associated supergene reveals loss of biocomplexity in Atlantic cod. Science Advances, 5(6), [2461]. https://doi.org/10.1126/sciadv.aav2461
Kess, Tony ; Bentzen, Paul ; Lehnert, Sarah J. ; Sylvester, Emma V.A. ; Lien, Sigbjorn ; Kent, Matthew P. ; Sinclair-Waters, Marion ; Morris, Corey J. ; Regular, Paul ; Fairweather, Robert ; Bradbury, Ian R. . / A migration-associated supergene reveals loss of biocomplexity in Atlantic cod. In: Science Advances. 2019 ; Vol. 5, No. 6.
@article{cbe7cde8332e4573aa4f1049030e5c89,
title = "A migration-associated supergene reveals loss of biocomplexity in Atlantic cod",
abstract = "Chromosome structural variation may underpin ecologically important intraspecific diversity by reducing recombination within supergenes containing linked, coadapted alleles. Here, we confirm that an ancient chromosomal rearrangement is strongly associated with migratory phenotype and individual genetic structure in Atlantic cod (Gadus morhua) across the Northwest Atlantic. We reconstruct trends in effective population size over the last century and reveal declines in effective population size matching onset of industrialized harvest (after 1950). We find different demographic trajectories between individuals homozygous for the chromosomal rearrangement relative to heterozygous or homozygous individuals for the noninverted haplotype, suggesting different selective histories across the past 150 years. These results illustrate how chromosomal structural diversity can mediate fine-scale genetic, phenotypic, and demographic variation in a highly connected marine species and show how overfishing may have led to loss of biocomplexity within Northern cod stock.",
keywords = "1184 Genetics, developmental biology, physiology, EFFECTIVE POPULATION-SIZE, LINKAGE DISEQUILIBRIUM, SELECTIVE SWEEPS, GADUS-MORHUA, R PACKAGE, EVOLUTION, INVERSIONS, DIVERGENCE, SCANS, CONSEQUENCES",
author = "Tony Kess and Paul Bentzen and Lehnert, {Sarah J.} and Sylvester, {Emma V.A.} and Sigbjorn Lien and Kent, {Matthew P.} and Marion Sinclair-Waters and Morris, {Corey J.} and Paul Regular and Robert Fairweather and Bradbury, {Ian R.}",
year = "2019",
month = "6",
day = "26",
doi = "10.1126/sciadv.aav2461",
language = "English",
volume = "5",
journal = "Science Advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science (AAAS)",
number = "6",

}

Kess, T, Bentzen, P, Lehnert, SJ, Sylvester, EVA, Lien, S, Kent, MP, Sinclair-Waters, M, Morris, CJ, Regular, P, Fairweather, R & Bradbury, IR 2019, 'A migration-associated supergene reveals loss of biocomplexity in Atlantic cod' Science Advances, vol. 5, no. 6, 2461. https://doi.org/10.1126/sciadv.aav2461

A migration-associated supergene reveals loss of biocomplexity in Atlantic cod. / Kess, Tony; Bentzen, Paul; Lehnert, Sarah J.; Sylvester, Emma V.A.; Lien, Sigbjorn; Kent, Matthew P.; Sinclair-Waters, Marion; Morris, Corey J.; Regular, Paul; Fairweather, Robert; Bradbury, Ian R. .

In: Science Advances, Vol. 5, No. 6, 2461, 26.06.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A migration-associated supergene reveals loss of biocomplexity in Atlantic cod

AU - Kess, Tony

AU - Bentzen, Paul

AU - Lehnert, Sarah J.

AU - Sylvester, Emma V.A.

AU - Lien, Sigbjorn

AU - Kent, Matthew P.

AU - Sinclair-Waters, Marion

AU - Morris, Corey J.

AU - Regular, Paul

AU - Fairweather, Robert

AU - Bradbury, Ian R.

PY - 2019/6/26

Y1 - 2019/6/26

N2 - Chromosome structural variation may underpin ecologically important intraspecific diversity by reducing recombination within supergenes containing linked, coadapted alleles. Here, we confirm that an ancient chromosomal rearrangement is strongly associated with migratory phenotype and individual genetic structure in Atlantic cod (Gadus morhua) across the Northwest Atlantic. We reconstruct trends in effective population size over the last century and reveal declines in effective population size matching onset of industrialized harvest (after 1950). We find different demographic trajectories between individuals homozygous for the chromosomal rearrangement relative to heterozygous or homozygous individuals for the noninverted haplotype, suggesting different selective histories across the past 150 years. These results illustrate how chromosomal structural diversity can mediate fine-scale genetic, phenotypic, and demographic variation in a highly connected marine species and show how overfishing may have led to loss of biocomplexity within Northern cod stock.

AB - Chromosome structural variation may underpin ecologically important intraspecific diversity by reducing recombination within supergenes containing linked, coadapted alleles. Here, we confirm that an ancient chromosomal rearrangement is strongly associated with migratory phenotype and individual genetic structure in Atlantic cod (Gadus morhua) across the Northwest Atlantic. We reconstruct trends in effective population size over the last century and reveal declines in effective population size matching onset of industrialized harvest (after 1950). We find different demographic trajectories between individuals homozygous for the chromosomal rearrangement relative to heterozygous or homozygous individuals for the noninverted haplotype, suggesting different selective histories across the past 150 years. These results illustrate how chromosomal structural diversity can mediate fine-scale genetic, phenotypic, and demographic variation in a highly connected marine species and show how overfishing may have led to loss of biocomplexity within Northern cod stock.

KW - 1184 Genetics, developmental biology, physiology

KW - EFFECTIVE POPULATION-SIZE

KW - LINKAGE DISEQUILIBRIUM

KW - SELECTIVE SWEEPS

KW - GADUS-MORHUA

KW - R PACKAGE

KW - EVOLUTION

KW - INVERSIONS

KW - DIVERGENCE

KW - SCANS

KW - CONSEQUENCES

U2 - 10.1126/sciadv.aav2461

DO - 10.1126/sciadv.aav2461

M3 - Article

VL - 5

JO - Science Advances

JF - Science Advances

SN - 2375-2548

IS - 6

M1 - 2461

ER -

Kess T, Bentzen P, Lehnert SJ, Sylvester EVA, Lien S, Kent MP et al. A migration-associated supergene reveals loss of biocomplexity in Atlantic cod. Science Advances. 2019 Jun 26;5(6). 2461. https://doi.org/10.1126/sciadv.aav2461