A Multifunctional Nanocomplex for Enhanced Cell Uptake, Endosomal Escape and Improved Cancer Therapeutic Effect

Patrick Vingadas Almeida, Mohammad-Ali Shahbazi, Alexandra Correia, Ermei Mikael Mäkilä, Marianna Leena Kemell, Jarno Salonen, Helder Almeida Santos

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Aim: To evaluate the chemotherapeutic potential of a novel multifunctional nanocomposite encapsulating both porous silicon (PSi) and gold (Au) nanoparticles in a polymeric nanocomplex. Materials & Methods: The nanocomposite was physicochemically characterized and evaluated in vitro for biocompatibility, cellular internalization, endosomolytic properties, cytoplasmatic drug delivery and chemotherapeutic efficacy. Results: The nanocomposites were successfully produced and exhibited adequate physicochemical properties and superior in vitro cyto- and hemo-compatibilities. The encapsulation of PSi nanoparticles in the nanocomplexes significantly enhanced their cellular internalization and enabled their endosomal escape, resulting in the efficient cytoplasmic delivery of these nanosystems. Sorafenib-loaded nanocomposites showed a potent in vitro anti-proliferative effect on MDA-MB-231 breast cancer cells. Conclusion: The multifunctional nanocomposite herein presented exhibits great potential as a chemotherapeutic nanoplatform.
Original languageEnglish
JournalNanomedicine
Volume12
Issue number12
Pages (from-to)1401-1420
Number of pages20
ISSN1743-5889
DOIs
Publication statusPublished - Jun 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 116 Chemical sciences
  • 317 Pharmacy
  • cancer theranostics
  • endosomal escape
  • gold nanoparticles
  • multifunctional nanocomposite
  • nanocomplexes
  • porous silicon nanoparticles
  • sorafenib

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