A Nano-in-Nano Vector: Merging the Best of Polymeric Nanoparticles and Drug Nanocrystals

Research output: Contribution to journalArticleScientificpeer-review

Abstract

An advanced approach that can prepare narrowly size distributed nanomaterials with ultrahigh mass fraction of therapeutics, superior colloidal stability, minimal off-target effects, as well as precisely controlled drug release profiles, is strongly desirable. Herein, we have successfully fabricated an optimal nano-in-nano vector, consisting of a drug (sorafenib, SFN or itraconazole, ICZ) nanocrystal core and a polymer (folic acid conjugated spermine-functionalized acetalated dextran, ADS-FA) shell on a 1:1 ratio (HSFN@ADS-FA or ICZ@ADS-FA). With the help of computational fluid dynamics, we computed the concentration and velocity field in the microfluidic domain as well as the mixing time between the solvent and non-solvent for nanovector precursors. The favorable features of both polymer nanoparticles and drug nanocrystals have been inherited by the obtained nano-in-nano vector, showing ultrahigh drug loading degree, biodegradability, pH-responsive fast dissolution, high stability in blood plasma,
and ease of surface functionalization. Furthermore, the half maximal inhibitory concentration value of the nano-in-nano HSFN@ADS-FA was ~54 times lower than the conventional nanovector (LSFN@ADS-FA) with a low drug loading degree. Overall, our nanovector merges the best of polymeric nanoparticles and drug nanocrystals.
Original languageEnglish
Article number1604508
JournalAdvanced Functional Materials
Volume27
Issue number9
Number of pages13
ISSN1616-301X
DOIs
Publication statusPublished - 3 Mar 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 116 Chemical sciences
  • 221 Nano-technology
  • 317 Pharmacy
  • computational fluid dynamics
  • nano-in-nano
  • targeting drug delivery
  • ultrahigh drug loading
  • HIGH-THROUGHPUT SYNTHESIS
  • MICROFLUIDIC PLATFORM
  • DELIVERY-SYSTEMS
  • POROUS SILICON
  • FOLIC-ACID
  • ACETALATED DEXTRAN
  • PH
  • RELEASE
  • CANCER
  • PHARMACOKINETICS

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