A Nano-in-Nano Vector: Merging the Best of Polymeric Nanoparticles and Drug Nanocrystals

Research output: Contribution to journalArticleScientificpeer-review

Abstract

An advanced approach that can prepare narrowly size distributed nanomaterials with ultrahigh mass fraction of therapeutics, superior colloidal stability, minimal off-target effects, as well as precisely controlled drug release profiles, is strongly desirable. Herein, we have successfully fabricated an optimal nano-in-nano vector, consisting of a drug (sorafenib, SFN or itraconazole, ICZ) nanocrystal core and a polymer (folic acid conjugated spermine-functionalized acetalated dextran, ADS-FA) shell on a 1:1 ratio (HSFN@ADS-FA or ICZ@ADS-FA). With the help of computational fluid dynamics, we computed the concentration and velocity field in the microfluidic domain as well as the mixing time between the solvent and non-solvent for nanovector precursors. The favorable features of both polymer nanoparticles and drug nanocrystals have been inherited by the obtained nano-in-nano vector, showing ultrahigh drug loading degree, biodegradability, pH-responsive fast dissolution, high stability in blood plasma,
and ease of surface functionalization. Furthermore, the half maximal inhibitory concentration value of the nano-in-nano HSFN@ADS-FA was ~54 times lower than the conventional nanovector (LSFN@ADS-FA) with a low drug loading degree. Overall, our nanovector merges the best of polymeric nanoparticles and drug nanocrystals.
Original languageEnglish
Article number1604508
JournalAdvanced Functional Materials
Volume27
Issue number9
Number of pages13
ISSN1616-301X
DOIs
Publication statusPublished - 3 Mar 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 116 Chemical sciences
  • 221 Nano-technology
  • 317 Pharmacy
  • computational fluid dynamics
  • nano-in-nano
  • targeting drug delivery
  • ultrahigh drug loading
  • HIGH-THROUGHPUT SYNTHESIS
  • MICROFLUIDIC PLATFORM
  • DELIVERY-SYSTEMS
  • POROUS SILICON
  • FOLIC-ACID
  • ACETALATED DEXTRAN
  • PH
  • RELEASE
  • CANCER
  • PHARMACOKINETICS

Cite this

@article{a5b224d378194ec58b4b633aecabc200,
title = "A Nano-in-Nano Vector: Merging the Best of Polymeric Nanoparticles and Drug Nanocrystals",
abstract = "An advanced approach that can prepare narrowly size distributed nanomaterials with ultrahigh mass fraction of therapeutics, superior colloidal stability, minimal off-target effects, as well as precisely controlled drug release profiles, is strongly desirable. Herein, we have successfully fabricated an optimal nano-in-nano vector, consisting of a drug (sorafenib, SFN or itraconazole, ICZ) nanocrystal core and a polymer (folic acid conjugated spermine-functionalized acetalated dextran, ADS-FA) shell on a 1:1 ratio (HSFN@ADS-FA or ICZ@ADS-FA). With the help of computational fluid dynamics, we computed the concentration and velocity field in the microfluidic domain as well as the mixing time between the solvent and non-solvent for nanovector precursors. The favorable features of both polymer nanoparticles and drug nanocrystals have been inherited by the obtained nano-in-nano vector, showing ultrahigh drug loading degree, biodegradability, pH-responsive fast dissolution, high stability in blood plasma, and ease of surface functionalization. Furthermore, the half maximal inhibitory concentration value of the nano-in-nano HSFN@ADS-FA was ~54 times lower than the conventional nanovector (LSFN@ADS-FA) with a low drug loading degree. Overall, our nanovector merges the best of polymeric nanoparticles and drug nanocrystals.",
keywords = "116 Chemical sciences, 221 Nano-technology, 317 Pharmacy, computational fluid dynamics , nano-in-nano , targeting drug delivery , ultrahigh drug loading , HIGH-THROUGHPUT SYNTHESIS , MICROFLUIDIC PLATFORM , DELIVERY-SYSTEMS , POROUS SILICON , FOLIC-ACID , ACETALATED DEXTRAN , PH , RELEASE , CANCER , PHARMACOKINETICS",
author = "Dongfei Liu and {Rodr{\'i}guez Bernuz}, Cristina and Jin Fan and Wei Li and Alexandra Correia and Hirvonen, {Jouni Tapio} and {Almeida Santos}, Helder",
year = "2017",
month = "3",
day = "3",
doi = "10.1002/adfm.201604508",
language = "English",
volume = "27",
journal = "Advanced Functional Materials",
issn = "1616-301X",
publisher = "Wiley-VCH",
number = "9",

}

A Nano-in-Nano Vector: Merging the Best of Polymeric Nanoparticles and Drug Nanocrystals. / Liu, Dongfei; Rodríguez Bernuz, Cristina ; Fan, Jin; Li, Wei; Correia, Alexandra ; Hirvonen, Jouni Tapio; Almeida Santos, Helder.

In: Advanced Functional Materials, Vol. 27, No. 9, 1604508, 03.03.2017.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A Nano-in-Nano Vector: Merging the Best of Polymeric Nanoparticles and Drug Nanocrystals

AU - Liu, Dongfei

AU - Rodríguez Bernuz, Cristina

AU - Fan, Jin

AU - Li, Wei

AU - Correia, Alexandra

AU - Hirvonen, Jouni Tapio

AU - Almeida Santos, Helder

PY - 2017/3/3

Y1 - 2017/3/3

N2 - An advanced approach that can prepare narrowly size distributed nanomaterials with ultrahigh mass fraction of therapeutics, superior colloidal stability, minimal off-target effects, as well as precisely controlled drug release profiles, is strongly desirable. Herein, we have successfully fabricated an optimal nano-in-nano vector, consisting of a drug (sorafenib, SFN or itraconazole, ICZ) nanocrystal core and a polymer (folic acid conjugated spermine-functionalized acetalated dextran, ADS-FA) shell on a 1:1 ratio (HSFN@ADS-FA or ICZ@ADS-FA). With the help of computational fluid dynamics, we computed the concentration and velocity field in the microfluidic domain as well as the mixing time between the solvent and non-solvent for nanovector precursors. The favorable features of both polymer nanoparticles and drug nanocrystals have been inherited by the obtained nano-in-nano vector, showing ultrahigh drug loading degree, biodegradability, pH-responsive fast dissolution, high stability in blood plasma, and ease of surface functionalization. Furthermore, the half maximal inhibitory concentration value of the nano-in-nano HSFN@ADS-FA was ~54 times lower than the conventional nanovector (LSFN@ADS-FA) with a low drug loading degree. Overall, our nanovector merges the best of polymeric nanoparticles and drug nanocrystals.

AB - An advanced approach that can prepare narrowly size distributed nanomaterials with ultrahigh mass fraction of therapeutics, superior colloidal stability, minimal off-target effects, as well as precisely controlled drug release profiles, is strongly desirable. Herein, we have successfully fabricated an optimal nano-in-nano vector, consisting of a drug (sorafenib, SFN or itraconazole, ICZ) nanocrystal core and a polymer (folic acid conjugated spermine-functionalized acetalated dextran, ADS-FA) shell on a 1:1 ratio (HSFN@ADS-FA or ICZ@ADS-FA). With the help of computational fluid dynamics, we computed the concentration and velocity field in the microfluidic domain as well as the mixing time between the solvent and non-solvent for nanovector precursors. The favorable features of both polymer nanoparticles and drug nanocrystals have been inherited by the obtained nano-in-nano vector, showing ultrahigh drug loading degree, biodegradability, pH-responsive fast dissolution, high stability in blood plasma, and ease of surface functionalization. Furthermore, the half maximal inhibitory concentration value of the nano-in-nano HSFN@ADS-FA was ~54 times lower than the conventional nanovector (LSFN@ADS-FA) with a low drug loading degree. Overall, our nanovector merges the best of polymeric nanoparticles and drug nanocrystals.

KW - 116 Chemical sciences

KW - 221 Nano-technology

KW - 317 Pharmacy

KW - computational fluid dynamics

KW - nano-in-nano

KW - targeting drug delivery

KW - ultrahigh drug loading

KW - HIGH-THROUGHPUT SYNTHESIS

KW - MICROFLUIDIC PLATFORM

KW - DELIVERY-SYSTEMS

KW - POROUS SILICON

KW - FOLIC-ACID

KW - ACETALATED DEXTRAN

KW - PH

KW - RELEASE

KW - CANCER

KW - PHARMACOKINETICS

UR - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291616-3028

U2 - 10.1002/adfm.201604508

DO - 10.1002/adfm.201604508

M3 - Article

VL - 27

JO - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-301X

IS - 9

M1 - 1604508

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