A phosphodiesterase pathway essential for lymphangiogenic growth arrest and maturation

Kari Alitalo

doi:10.1016/j.devcel.2024.01.007

A phosphodiesterase pathway essential for lymphangiogenic growth arrest and maturation

Kari Alitalo

HUSLAB

Research output: Contribution to journal › Comment/debate › Scientific

Abstract

In developing embryos, downregulation of lymphatic endothelial proliferation is needed for maturation of lymphatic vessels into a hierarchical network. In this issue of Developmental Cell, Carlantoni discover that phosphodiesterase2A controls lymphatic endothelial growth arrest and maturation via regulation of cGMP, p38 MAP kinase, and Notch pathway.

Original language	English
Journal	Developmental Cell
Volume	59
Issue number	3
Pages (from-to)	293-294
Number of pages	2
ISSN	1534-5807
DOIs	https://doi.org/10.1016/j.devcel.2024.01.007
Publication status	Published - 5 Feb 2024
MoE publication type	B1 Journal article

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Inc.

Fields of Science

3111 Biomedicine

Access to Document

10.1016/j.devcel.2024.01.007

Cite this

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title = "A phosphodiesterase pathway essential for lymphangiogenic growth arrest and maturation",

abstract = "In developing embryos, downregulation of lymphatic endothelial proliferation is needed for maturation of lymphatic vessels into a hierarchical network. In this issue of Developmental Cell, Carlantoni discover that phosphodiesterase2A controls lymphatic endothelial growth arrest and maturation via regulation of cGMP, p38 MAP kinase, and Notch pathway.",

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AU - Alitalo, Kari

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N2 - In developing embryos, downregulation of lymphatic endothelial proliferation is needed for maturation of lymphatic vessels into a hierarchical network. In this issue of Developmental Cell, Carlantoni discover that phosphodiesterase2A controls lymphatic endothelial growth arrest and maturation via regulation of cGMP, p38 MAP kinase, and Notch pathway.

AB - In developing embryos, downregulation of lymphatic endothelial proliferation is needed for maturation of lymphatic vessels into a hierarchical network. In this issue of Developmental Cell, Carlantoni discover that phosphodiesterase2A controls lymphatic endothelial growth arrest and maturation via regulation of cGMP, p38 MAP kinase, and Notch pathway.

KW - 3111 Biomedicine

U2 - 10.1016/j.devcel.2024.01.007

DO - 10.1016/j.devcel.2024.01.007

M3 - Comment/debate

C2 - 38320483

AN - SCOPUS:85184064422

SN - 1534-5807

VL - 59

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JO - Developmental Cell

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