A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

Tiina Immonen, Anniina Alakuijala, Marjo Hytönen, Kirsi Sainio, Dmitry Poteryaev, Mart Saarma, Michael Pasternack, Hannu Sariola

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.
    Original languageEnglish
    JournalExperimental Neurology
    Volume210
    Pages (from-to)793-796
    Number of pages4
    ISSN0014-4886
    DOIs
    Publication statusPublished - 2008
    MoE publication typeA1 Journal article-refereed

    Cite this

    @article{06a9f84ba5d74790bb95da38ae20599e,
    title = "A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus",
    abstract = "The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.",
    author = "Tiina Immonen and Anniina Alakuijala and Marjo Hyt{\"o}nen and Kirsi Sainio and Dmitry Poteryaev and Mart Saarma and Michael Pasternack and Hannu Sariola",
    year = "2008",
    doi = "10.1016/j.expneurol.2007.12.018",
    language = "English",
    volume = "210",
    pages = "793--796",
    journal = "Experimental Neurology",
    issn = "0014-4886",
    publisher = "ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS",

    }

    A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus. / Immonen, Tiina; Alakuijala, Anniina; Hytönen, Marjo; Sainio, Kirsi; Poteryaev, Dmitry; Saarma, Mart; Pasternack, Michael; Sariola, Hannu.

    In: Experimental Neurology, Vol. 210, 2008, p. 793-796.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

    AU - Immonen, Tiina

    AU - Alakuijala, Anniina

    AU - Hytönen, Marjo

    AU - Sainio, Kirsi

    AU - Poteryaev, Dmitry

    AU - Saarma, Mart

    AU - Pasternack, Michael

    AU - Sariola, Hannu

    PY - 2008

    Y1 - 2008

    N2 - The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.

    AB - The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.

    U2 - 10.1016/j.expneurol.2007.12.018

    DO - 10.1016/j.expneurol.2007.12.018

    M3 - Article

    VL - 210

    SP - 793

    EP - 796

    JO - Experimental Neurology

    JF - Experimental Neurology

    SN - 0014-4886

    ER -