A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

Tiina Immonen; Anniina Alakuijala; Marjo Hytönen; Kirsi Sainio; Dmitry Poteryaev; Mart Saarma; Michael Pasternack; Hannu Sariola

doi:10.1016/j.expneurol.2007.12.018

A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

Tiina Immonen, Anniina Alakuijala, Marjo Hytönen, Kirsi Sainio, Dmitry Poteryaev, Mart Saarma, Michael Pasternack, Hannu Sariola

Department of Biochemistry and Developmental Biology

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.

Original language	English
Journal	Experimental Neurology
Volume	210
Issue number	2
Pages (from-to)	793-796
Number of pages	4
ISSN	0014-4886
DOIs	https://doi.org/10.1016/j.expneurol.2007.12.018
Publication status	Published - 2008
MoE publication type	A1 Journal article-refereed

Access to Document

10.1016/j.expneurol.2007.12.018

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WFG-4RH94YB-1-8&_cdi=6794&_user=949111&_orig=browse&_coverDate=04%2F30%2F2008&_sk=997899997&view=c&wchp=dGLbVzz-zSkzV&md5=d29758f5292712a2aac86abec07a35c3&ie=/sdarticle.pdf

Cite this

@article{06a9f84ba5d74790bb95da38ae20599e,

title = "A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus",

abstract = "The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.",

author = "Tiina Immonen and Anniina Alakuijala and Marjo Hyt{\"o}nen and Kirsi Sainio and Dmitry Poteryaev and Mart Saarma and Michael Pasternack and Hannu Sariola",

year = "2008",

doi = "10.1016/j.expneurol.2007.12.018",

language = "English",

volume = "210",

pages = "793--796",

journal = "Experimental Neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

AU - Immonen, Tiina

AU - Alakuijala, Anniina

AU - Hytönen, Marjo

AU - Sainio, Kirsi

AU - Poteryaev, Dmitry

AU - Saarma, Mart

AU - Pasternack, Michael

AU - Sariola, Hannu

PY - 2008

Y1 - 2008

N2 - The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.

AB - The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.expneurol.2007.12.018

DO - 10.1016/j.expneurol.2007.12.018

M3 - Article

SN - 0014-4886

VL - 210

SP - 793

EP - 796

JO - Experimental Neurology

JF - Experimental Neurology

IS - 2

ER -