A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

Research output: Contribution to journalArticleScientificpeer-review


The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.
Original languageEnglish
JournalExperimental Neurology
Issue number2
Pages (from-to)793-796
Number of pages4
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Cite this