A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

Tony S. Eteläinen; M.Catarina Silva; Johanna K. Uhari-Väänänen; Francesca De Lorenzo; Maria H. Jäntti; Hengjing Cui; Marta Chavero-Pieres; Tommi Kilpeläinen; Christina Mechtler; Reinis Svarcbahs; Erin Seppälä; Juha R. Savinainen; Elena Puris; Gert Fricker; Mikko Gynther; Ulrika H. Julku; Henri J. Huttunen; Stephen J. Haggarty; Timo Myöhänen

doi:10.1126/scitranslmed.abq2915

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

Tony S. Eteläinen, M.Catarina Silva, Johanna K. Uhari-Väänänen, Francesca De Lorenzo, Maria H. Jäntti, Hengjing Cui, Marta Chavero-Pieres, Tommi Kilpeläinen, Christina Mechtler, Reinis Svarcbahs, Erin Seppälä, Juha R. Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika H. Julku, Henri J. Huttunen, Stephen J. Haggarty, Timo Myöhänen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	eabq2915
Journal	Science translational medicine
Volume	15
Issue number	691
ISSN	1946-6234
DOIs	https://doi.org/10.1126/scitranslmed.abq2915
Publication status	Published - 12 Apr 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

317 Pharmacy

Access to Document

10.1126/scitranslmed.abq2915

Etelainen et al Sci Trans Med author versionAccepted author manuscript, 1.6 MBLicence: CC BY

Cite this

Eteläinen, T. S., Silva, M. C., Uhari-Väänänen, J. K., De Lorenzo, F., Jäntti, M. H., Cui, H., Chavero-Pieres, M., Kilpeläinen, T., Mechtler, C., Svarcbahs, R., Seppälä, E., Savinainen, J. R., Puris, E., Fricker, G., Gynther, M., Julku, U. H., Huttunen, H. J., Haggarty, S. J., & Myöhänen, T. (2023). A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy. Science translational medicine, 15(691), Article eabq2915. https://doi.org/10.1126/scitranslmed.abq2915

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year = "2023",

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doi = "10.1126/scitranslmed.abq2915",

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Eteläinen, TS, Silva, MC, Uhari-Väänänen, JK , De Lorenzo, F, Jäntti, MH, Cui, H, Chavero-Pieres, M, Kilpeläinen, T, Mechtler, C, Svarcbahs, R, Seppälä, E, Savinainen, JR, Puris, E, Fricker, G, Gynther, M, Julku, UH, Huttunen, HJ, Haggarty, SJ & Myöhänen, T 2023, 'A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy', Science translational medicine, vol. 15, no. 691, eabq2915. https://doi.org/10.1126/scitranslmed.abq2915

TY - JOUR

T1 - A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy

AU - Eteläinen, Tony S.

AU - Silva, M.Catarina

AU - Uhari-Väänänen, Johanna K.

AU - De Lorenzo, Francesca

AU - Jäntti, Maria H.

AU - Cui, Hengjing

AU - Chavero-Pieres, Marta

AU - Kilpeläinen, Tommi

AU - Mechtler, Christina

AU - Svarcbahs, Reinis

AU - Seppälä, Erin

AU - Savinainen, Juha R.

AU - Puris, Elena

AU - Fricker, Gert

AU - Gynther, Mikko

AU - Julku, Ulrika H.

AU - Huttunen, Henri J.

AU - Haggarty, Stephen J.

AU - Myöhänen, Timo

PY - 2023/4/12

Y1 - 2023/4/12

KW - 317 Pharmacy

U2 - 10.1126/scitranslmed.abq2915

DO - 10.1126/scitranslmed.abq2915

M3 - Article

SN - 1946-6234

VL - 15

JO - Science translational medicine

JF - Science translational medicine

IS - 691

M1 - eabq2915

ER -