A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

Lies Van Horebeek; Kelly Hilven; Klara Mallants; Annemarie Van Nieuwenhuijze; Tiina Kelkka; Paula Savola; Satu Mustjoki; Susan M. Schlenner; Adrian Liston; Benedicte Dubois; An Goris

doi:10.1093/hmg/ddy425

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

Lies Van Horebeek, Kelly Hilven, Klara Mallants, Annemarie Van Nieuwenhuijze, Tiina Kelkka, Paula Savola, Satu Mustjoki, Susan M. Schlenner, Adrian Liston, Benedicte Dubois, An Goris

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Human Molecular Genetics
Volume	28
Issue number	8
Pages (from-to)	1369-1380
Number of pages	12
ISSN	0964-6906
DOIs	https://doi.org/10.1093/hmg/ddy425
Publication status	Published - 15 Apr 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

T-CELLS
CLONAL HEMATOPOIESIS
STAT3 MUTATIONS
GENERATION
CANCER
RISK
MOSAICISM
DISCOVERY
FREQUENCY
EXPANSION
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
1184 Genetics, developmental biology, physiology

Access to Document

10.1093/hmg/ddy425

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune diseaseAccepted author manuscript, 717 KB
ddy425Final published version, 1.35 MBLicence: CC BY

Cite this

Van Horebeek, L., Hilven, K., Mallants, K., Van Nieuwenhuijze, A., Kelkka, T., Savola, P., Mustjoki, S., Schlenner, S. M., Liston, A., Dubois, B., & Goris, A. (2019). A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease. Human Molecular Genetics, 28(8), 1369-1380. https://doi.org/10.1093/hmg/ddy425

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title = "A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease",

keywords = "T-CELLS, CLONAL HEMATOPOIESIS, STAT3 MUTATIONS, GENERATION, CANCER, RISK, MOSAICISM, DISCOVERY, FREQUENCY, EXPANSION, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology, 1184 Genetics, developmental biology, physiology",

author = "{Van Horebeek}, Lies and Kelly Hilven and Klara Mallants and {Van Nieuwenhuijze}, Annemarie and Tiina Kelkka and Paula Savola and Satu Mustjoki and Schlenner, {Susan M.} and Adrian Liston and Benedicte Dubois and An Goris",

year = "2019",

month = apr,

day = "15",

doi = "10.1093/hmg/ddy425",

language = "English",

volume = "28",

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journal = "Human Molecular Genetics",

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Van Horebeek, L, Hilven, K, Mallants, K, Van Nieuwenhuijze, A, Kelkka, T, Savola, P , Mustjoki, S, Schlenner, SM, Liston, A, Dubois, B & Goris, A 2019, 'A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease', Human Molecular Genetics, vol. 28, no. 8, pp. 1369-1380. https://doi.org/10.1093/hmg/ddy425

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease. / Van Horebeek, Lies; Hilven, Kelly; Mallants, Klara et al.
In: Human Molecular Genetics, Vol. 28, No. 8, 15.04.2019, p. 1369-1380.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease

AU - Van Horebeek, Lies

AU - Hilven, Kelly

AU - Mallants, Klara

AU - Van Nieuwenhuijze, Annemarie

AU - Kelkka, Tiina

AU - Savola, Paula

AU - Mustjoki, Satu

AU - Schlenner, Susan M.

AU - Liston, Adrian

AU - Dubois, Benedicte

AU - Goris, An

PY - 2019/4/15

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KW - T-CELLS

KW - CLONAL HEMATOPOIESIS

KW - STAT3 MUTATIONS

KW - GENERATION

KW - CANCER

KW - RISK

KW - MOSAICISM

KW - DISCOVERY

KW - FREQUENCY

KW - EXPANSION

KW - 3111 Biomedicine

KW - 1182 Biochemistry, cell and molecular biology

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.1093/hmg/ddy425

DO - 10.1093/hmg/ddy425

M3 - Article

SN - 0964-6906

VL - 28

SP - 1369

EP - 1380

JO - Human Molecular Genetics

JF - Human Molecular Genetics

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ER -