A scaffold replacement approach towards new sirtuin 2 inhibitors

Tina Seifert, Marcus Malo, Tarja Kokkola, E. Johanna L. Steen, Kristian Meinander, Erik A. A. Wallen, Elina M. Jarho, Kristina Luthman

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article number115231
JournalBioorganic & Medicinal Chemistry
Volume28
Issue number2
Number of pages12
ISSN0968-0896
DOIs
Publication statusPublished - 15 Jan 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Scaffold
  • Sirtuin
  • SIRT2
  • Inhibitor
  • Benzothiazine-1,1-dioxide
  • Benzothiadiazine-1,1-dioxides
  • Saccharin
  • Quinolin-4-one
  • Docking
  • FORCE-FIELD
  • CHROMAN-4-ONE
  • PROTEIN
  • BRAIN
  • 1182 Biochemistry, cell and molecular biology
  • 116 Chemical sciences
  • 317 Pharmacy

Cite this

Seifert, T., Malo, M., Kokkola, T., Steen, E. J. L., Meinander, K., Wallen, E. A. A., ... Luthman, K. (2020). A scaffold replacement approach towards new sirtuin 2 inhibitors. Bioorganic & Medicinal Chemistry, 28(2), [115231]. https://doi.org/10.1016/j.bmc.2019.115231
Seifert, Tina ; Malo, Marcus ; Kokkola, Tarja ; Steen, E. Johanna L. ; Meinander, Kristian ; Wallen, Erik A. A. ; Jarho, Elina M. ; Luthman, Kristina. / A scaffold replacement approach towards new sirtuin 2 inhibitors. In: Bioorganic & Medicinal Chemistry. 2020 ; Vol. 28, No. 2.
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title = "A scaffold replacement approach towards new sirtuin 2 inhibitors",
keywords = "Scaffold, Sirtuin, SIRT2, Inhibitor, Benzothiazine-1,1-dioxide, Benzothiadiazine-1,1-dioxides, Saccharin, Quinolin-4-one, Docking, FORCE-FIELD, CHROMAN-4-ONE, PROTEIN, BRAIN, 1182 Biochemistry, cell and molecular biology, 116 Chemical sciences, 317 Pharmacy",
author = "Tina Seifert and Marcus Malo and Tarja Kokkola and Steen, {E. Johanna L.} and Kristian Meinander and Wallen, {Erik A. A.} and Jarho, {Elina M.} and Kristina Luthman",
year = "2020",
month = "1",
day = "15",
doi = "10.1016/j.bmc.2019.115231",
language = "English",
volume = "28",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Scientific Publ. Co",
number = "2",

}

Seifert, T, Malo, M, Kokkola, T, Steen, EJL, Meinander, K, Wallen, EAA, Jarho, EM & Luthman, K 2020, 'A scaffold replacement approach towards new sirtuin 2 inhibitors', Bioorganic & Medicinal Chemistry, vol. 28, no. 2, 115231. https://doi.org/10.1016/j.bmc.2019.115231

A scaffold replacement approach towards new sirtuin 2 inhibitors. / Seifert, Tina; Malo, Marcus; Kokkola, Tarja; Steen, E. Johanna L.; Meinander, Kristian; Wallen, Erik A. A.; Jarho, Elina M.; Luthman, Kristina.

In: Bioorganic & Medicinal Chemistry, Vol. 28, No. 2, 115231, 15.01.2020.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - A scaffold replacement approach towards new sirtuin 2 inhibitors

AU - Seifert, Tina

AU - Malo, Marcus

AU - Kokkola, Tarja

AU - Steen, E. Johanna L.

AU - Meinander, Kristian

AU - Wallen, Erik A. A.

AU - Jarho, Elina M.

AU - Luthman, Kristina

PY - 2020/1/15

Y1 - 2020/1/15

KW - Scaffold

KW - Sirtuin

KW - SIRT2

KW - Inhibitor

KW - Benzothiazine-1,1-dioxide

KW - Benzothiadiazine-1,1-dioxides

KW - Saccharin

KW - Quinolin-4-one

KW - Docking

KW - FORCE-FIELD

KW - CHROMAN-4-ONE

KW - PROTEIN

KW - BRAIN

KW - 1182 Biochemistry, cell and molecular biology

KW - 116 Chemical sciences

KW - 317 Pharmacy

U2 - 10.1016/j.bmc.2019.115231

DO - 10.1016/j.bmc.2019.115231

M3 - Article

VL - 28

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 2

M1 - 115231

ER -