Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

Chiara Bardella, Mona El-Bahrawy, Norma Frizzell, Julie Adam, Nicola Ternette, Emine Hatipoglu, Kimberley Howarth, Linda O'Flaherty, Ian Roberts, Gareth Turner, Jennifer Taylor, Konstantinos Giaslakiotis, Valentine M. Macaulay, Adrian L. Harris, Ashish Chandra, Heli J. Lehtonen, Virpi Launonen, Lauri A. Aaltonen, Christopher W. Pugh, Radu Mihai & 6 others David Trudgian, Benedikt Kessler, John W. Baynes, Peter J. Ratcliffe, Ian P. Tomlinson, Patrick J. Pollard

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Pathology
Volume225
Issue number1
Pages (from-to)4-11
Number of pages8
ISSN0022-3417
DOIs
Publication statusPublished - 2011
MoE publication typeA1 Journal article-refereed

Fields of Science

  • succination
  • renal cancer
  • mitochondria
  • fumarate hydratase
  • HLRCC
  • immunhistochemistry
  • mouse models
  • RENAL-CELL CANCER
  • HEREDITARY LEIOMYOMATOSIS
  • MITOCHONDRIAL STRESS
  • FH MUTATIONS
  • PARAGANGLIOMA
  • GENE
  • DEHYDROGENASE
  • INACTIVATION
  • 3111 Biomedicine
  • 3122 Cancers

Cite this

Bardella, C., El-Bahrawy, M., Frizzell, N., Adam, J., Ternette, N., Hatipoglu, E., ... Pollard, P. J. (2011). Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. Journal of Pathology, 225(1), 4-11. https://doi.org/10.1002/path.2932
Bardella, Chiara ; El-Bahrawy, Mona ; Frizzell, Norma ; Adam, Julie ; Ternette, Nicola ; Hatipoglu, Emine ; Howarth, Kimberley ; O'Flaherty, Linda ; Roberts, Ian ; Turner, Gareth ; Taylor, Jennifer ; Giaslakiotis, Konstantinos ; Macaulay, Valentine M. ; Harris, Adrian L. ; Chandra, Ashish ; Lehtonen, Heli J. ; Launonen, Virpi ; Aaltonen, Lauri A. ; Pugh, Christopher W. ; Mihai, Radu ; Trudgian, David ; Kessler, Benedikt ; Baynes, John W. ; Ratcliffe, Peter J. ; Tomlinson, Ian P. ; Pollard, Patrick J. / Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. In: Journal of Pathology. 2011 ; Vol. 225, No. 1. pp. 4-11.
@article{9a0b95ccdbd4402d8680e5e689031694,
title = "Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status",
keywords = "succination, renal cancer, mitochondria, fumarate hydratase, HLRCC, immunhistochemistry, mouse models, RENAL-CELL CANCER, HEREDITARY LEIOMYOMATOSIS, MITOCHONDRIAL STRESS, FH MUTATIONS, PARAGANGLIOMA, GENE, DEHYDROGENASE, INACTIVATION, 3111 Biomedicine, 3122 Cancers",
author = "Chiara Bardella and Mona El-Bahrawy and Norma Frizzell and Julie Adam and Nicola Ternette and Emine Hatipoglu and Kimberley Howarth and Linda O'Flaherty and Ian Roberts and Gareth Turner and Jennifer Taylor and Konstantinos Giaslakiotis and Macaulay, {Valentine M.} and Harris, {Adrian L.} and Ashish Chandra and Lehtonen, {Heli J.} and Virpi Launonen and Aaltonen, {Lauri A.} and Pugh, {Christopher W.} and Radu Mihai and David Trudgian and Benedikt Kessler and Baynes, {John W.} and Ratcliffe, {Peter J.} and Tomlinson, {Ian P.} and Pollard, {Patrick J.}",
year = "2011",
doi = "10.1002/path.2932",
language = "English",
volume = "225",
pages = "4--11",
journal = "Journal of Pathology",
issn = "0022-3417",
publisher = "John Wiley & Sons Ltd.",
number = "1",

}

Bardella, C, El-Bahrawy, M, Frizzell, N, Adam, J, Ternette, N, Hatipoglu, E, Howarth, K, O'Flaherty, L, Roberts, I, Turner, G, Taylor, J, Giaslakiotis, K, Macaulay, VM, Harris, AL, Chandra, A, Lehtonen, HJ, Launonen, V, Aaltonen, LA, Pugh, CW, Mihai, R, Trudgian, D, Kessler, B, Baynes, JW, Ratcliffe, PJ, Tomlinson, IP & Pollard, PJ 2011, 'Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status', Journal of Pathology, vol. 225, no. 1, pp. 4-11. https://doi.org/10.1002/path.2932

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. / Bardella, Chiara; El-Bahrawy, Mona; Frizzell, Norma; Adam, Julie; Ternette, Nicola; Hatipoglu, Emine; Howarth, Kimberley; O'Flaherty, Linda; Roberts, Ian; Turner, Gareth; Taylor, Jennifer; Giaslakiotis, Konstantinos; Macaulay, Valentine M.; Harris, Adrian L.; Chandra, Ashish; Lehtonen, Heli J.; Launonen, Virpi; Aaltonen, Lauri A.; Pugh, Christopher W.; Mihai, Radu; Trudgian, David; Kessler, Benedikt; Baynes, John W.; Ratcliffe, Peter J.; Tomlinson, Ian P.; Pollard, Patrick J.

In: Journal of Pathology, Vol. 225, No. 1, 2011, p. 4-11.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

AU - Bardella, Chiara

AU - El-Bahrawy, Mona

AU - Frizzell, Norma

AU - Adam, Julie

AU - Ternette, Nicola

AU - Hatipoglu, Emine

AU - Howarth, Kimberley

AU - O'Flaherty, Linda

AU - Roberts, Ian

AU - Turner, Gareth

AU - Taylor, Jennifer

AU - Giaslakiotis, Konstantinos

AU - Macaulay, Valentine M.

AU - Harris, Adrian L.

AU - Chandra, Ashish

AU - Lehtonen, Heli J.

AU - Launonen, Virpi

AU - Aaltonen, Lauri A.

AU - Pugh, Christopher W.

AU - Mihai, Radu

AU - Trudgian, David

AU - Kessler, Benedikt

AU - Baynes, John W.

AU - Ratcliffe, Peter J.

AU - Tomlinson, Ian P.

AU - Pollard, Patrick J.

PY - 2011

Y1 - 2011

KW - succination

KW - renal cancer

KW - mitochondria

KW - fumarate hydratase

KW - HLRCC

KW - immunhistochemistry

KW - mouse models

KW - RENAL-CELL CANCER

KW - HEREDITARY LEIOMYOMATOSIS

KW - MITOCHONDRIAL STRESS

KW - FH MUTATIONS

KW - PARAGANGLIOMA

KW - GENE

KW - DEHYDROGENASE

KW - INACTIVATION

KW - 3111 Biomedicine

KW - 3122 Cancers

U2 - 10.1002/path.2932

DO - 10.1002/path.2932

M3 - Article

VL - 225

SP - 4

EP - 11

JO - Journal of Pathology

JF - Journal of Pathology

SN - 0022-3417

IS - 1

ER -