Actin Filament Structures in Migrating Cells

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Cell migration is necessary for several developmental processes in multicellular organisms. Furthermore, many physiological processes such as wound healing and immunological events in adult animals are dependent on cell migration. Consequently, defects in cell migration are linked to various diseases including immunological disorders as well as cancer progression and metastasis formation. Cell migration is driven by specific protrusive and contractile actin filament structures, but the types and relative contributions of these actin filament arrays vary depending on the cell type and the environment of the cell. In this chapter, we introduce the most important actin filament structures that contribute to mesenchymal and amoeboid cell migration modes and discuss the mechanisms by which the assembly and turnover of these structures are controlled by various actin-binding proteins.
Original languageEnglish
Title of host publicationThe Actin Cytoskeleton
EditorsBrigitte M. Jockush
Number of pages30
Place of PublicationCham
PublisherSpringer International Publishing
Publication date2017
Pages123-152
ISBN (Print)978-3-319-46369-8
ISBN (Electronic)978-3-319-46371-1
DOIs
Publication statusPublished - 2017
MoE publication typeA3 Book chapter

Publication series

NameHandbook of Experimental Pharmacology
Volume235
ISSN (Print)0171-2004

Fields of Science

  • 1182 Biochemistry, cell and molecular biology

Cite this

Lehtimäki, J. I., Hakala, M. K., & Lappalainen, P. J. (2017). Actin Filament Structures in Migrating Cells. In B. M. Jockush (Ed.), The Actin Cytoskeleton (pp. 123-152). (Handbook of Experimental Pharmacology; Vol. 235). Cham: Springer International Publishing . https://doi.org/10.1007/164_2016_28
Lehtimäki, Jaakko Ilmari ; Hakala, Markku Kasperi ; Lappalainen, Pekka Juhani. / Actin Filament Structures in Migrating Cells. The Actin Cytoskeleton. editor / Brigitte M. Jockush. Cham : Springer International Publishing , 2017. pp. 123-152 (Handbook of Experimental Pharmacology).
@inbook{d4f8f5d4dafc41c495ddca7b59911f86,
title = "Actin Filament Structures in Migrating Cells",
abstract = "Cell migration is necessary for several developmental processes in multicellular organisms. Furthermore, many physiological processes such as wound healing and immunological events in adult animals are dependent on cell migration. Consequently, defects in cell migration are linked to various diseases including immunological disorders as well as cancer progression and metastasis formation. Cell migration is driven by specific protrusive and contractile actin filament structures, but the types and relative contributions of these actin filament arrays vary depending on the cell type and the environment of the cell. In this chapter, we introduce the most important actin filament structures that contribute to mesenchymal and amoeboid cell migration modes and discuss the mechanisms by which the assembly and turnover of these structures are controlled by various actin-binding proteins.",
keywords = "1182 Biochemistry, cell and molecular biology",
author = "Lehtim{\"a}ki, {Jaakko Ilmari} and Hakala, {Markku Kasperi} and Lappalainen, {Pekka Juhani}",
year = "2017",
doi = "10.1007/164_2016_28",
language = "English",
isbn = "978-3-319-46369-8",
series = "Handbook of Experimental Pharmacology",
publisher = "Springer International Publishing",
pages = "123--152",
editor = "Jockush, {Brigitte M. }",
booktitle = "The Actin Cytoskeleton",
address = "International",

}

Lehtimäki, JI, Hakala, MK & Lappalainen, PJ 2017, Actin Filament Structures in Migrating Cells. in BM Jockush (ed.), The Actin Cytoskeleton. Handbook of Experimental Pharmacology, vol. 235, Springer International Publishing , Cham, pp. 123-152. https://doi.org/10.1007/164_2016_28

Actin Filament Structures in Migrating Cells. / Lehtimäki, Jaakko Ilmari; Hakala, Markku Kasperi; Lappalainen, Pekka Juhani.

The Actin Cytoskeleton. ed. / Brigitte M. Jockush. Cham : Springer International Publishing , 2017. p. 123-152 (Handbook of Experimental Pharmacology; Vol. 235).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

TY - CHAP

T1 - Actin Filament Structures in Migrating Cells

AU - Lehtimäki, Jaakko Ilmari

AU - Hakala, Markku Kasperi

AU - Lappalainen, Pekka Juhani

PY - 2017

Y1 - 2017

N2 - Cell migration is necessary for several developmental processes in multicellular organisms. Furthermore, many physiological processes such as wound healing and immunological events in adult animals are dependent on cell migration. Consequently, defects in cell migration are linked to various diseases including immunological disorders as well as cancer progression and metastasis formation. Cell migration is driven by specific protrusive and contractile actin filament structures, but the types and relative contributions of these actin filament arrays vary depending on the cell type and the environment of the cell. In this chapter, we introduce the most important actin filament structures that contribute to mesenchymal and amoeboid cell migration modes and discuss the mechanisms by which the assembly and turnover of these structures are controlled by various actin-binding proteins.

AB - Cell migration is necessary for several developmental processes in multicellular organisms. Furthermore, many physiological processes such as wound healing and immunological events in adult animals are dependent on cell migration. Consequently, defects in cell migration are linked to various diseases including immunological disorders as well as cancer progression and metastasis formation. Cell migration is driven by specific protrusive and contractile actin filament structures, but the types and relative contributions of these actin filament arrays vary depending on the cell type and the environment of the cell. In this chapter, we introduce the most important actin filament structures that contribute to mesenchymal and amoeboid cell migration modes and discuss the mechanisms by which the assembly and turnover of these structures are controlled by various actin-binding proteins.

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1007/164_2016_28

DO - 10.1007/164_2016_28

M3 - Chapter

SN - 978-3-319-46369-8

T3 - Handbook of Experimental Pharmacology

SP - 123

EP - 152

BT - The Actin Cytoskeleton

A2 - Jockush, Brigitte M.

PB - Springer International Publishing

CY - Cham

ER -

Lehtimäki JI, Hakala MK, Lappalainen PJ. Actin Filament Structures in Migrating Cells. In Jockush BM, editor, The Actin Cytoskeleton. Cham: Springer International Publishing . 2017. p. 123-152. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/164_2016_28