Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism

M Karpale; AJ Karajamaki; O Kummu; H Gylling; T Hyotylainen; M Oresic; A Tolonen; H Hautajarvi; MJ Savolainen; M Ala-Korpela; J Hukkanen; J Hakkola

doi:10.1111/bph.15433

Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism

M Karpale, AJ Karajamaki, O Kummu, H Gylling, T Hyotylainen, M Oresic, A Tolonen, H Hautajarvi, MJ Savolainen, M Ala-Korpela, J Hukkanen, J Hakkola

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	British Journal of Pharmacology
Volume	178
Issue number	12
Pages (from-to)	2461-2481
Number of pages	21
ISSN	0007-1188
DOIs	https://doi.org/10.1111/bph.15433
Publication status	Published - Jun 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

cholesterol
hypercholesterolemia
lathosterol
LDL
PCSK9
PXR
SREBP2
HMG-COA REDUCTASE
MAGNETIC-RESONANCE METABOLOMICS
BILE-ACID SYNTHESIS
GLUCOSE-HOMEOSTASIS
INSULIN-RESISTANCE
CHOLESTEROL LEVELS
ENZYME-INDUCTION
CONCISE GUIDE
SERUM-LEVELS
METABOLISM
3111 Biomedicine

Access to Document

10.1111/bph.15433

Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2‐mediated mechanismAccepted author manuscript, 2.51 MB
Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanismFinal published version, 9.02 MBLicence: CC BY

Cite this

Karpale, M., Karajamaki, AJ., Kummu, O., Gylling, H., Hyotylainen, T., Oresic, M., Tolonen, A., Hautajarvi, H., Savolainen, MJ., Ala-Korpela, M., Hukkanen, J., & Hakkola, J. (2021). Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism. British Journal of Pharmacology, 178(12), 2461-2481. https://doi.org/10.1111/bph.15433

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title = "Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism",

keywords = "cholesterol, hypercholesterolemia, lathosterol, LDL, PCSK9, PXR, SREBP2, HMG-COA REDUCTASE, MAGNETIC-RESONANCE METABOLOMICS, BILE-ACID SYNTHESIS, GLUCOSE-HOMEOSTASIS, INSULIN-RESISTANCE, CHOLESTEROL LEVELS, ENZYME-INDUCTION, CONCISE GUIDE, SERUM-LEVELS, METABOLISM, 3111 Biomedicine",

author = "M Karpale and AJ Karajamaki and O Kummu and H Gylling and T Hyotylainen and M Oresic and A Tolonen and H Hautajarvi and MJ Savolainen and M Ala-Korpela and J Hukkanen and J Hakkola",

year = "2021",

month = jun,

doi = "10.1111/bph.15433",

language = "English",

volume = "178",

pages = "2461--2481",

journal = "British Journal of Pharmacology",

issn = "0007-1188",

publisher = "John Wiley and Sons Inc",

number = "12",

}

Karpale, M, Karajamaki, AJ, Kummu, O, Gylling, H, Hyotylainen, T, Oresic, M, Tolonen, A, Hautajarvi, H, Savolainen, MJ, Ala-Korpela, M, Hukkanen, J & Hakkola, J 2021, 'Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism', British Journal of Pharmacology, vol. 178, no. 12, pp. 2461-2481. https://doi.org/10.1111/bph.15433

TY - JOUR

T1 - Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism

AU - Karpale, M

AU - Karajamaki, AJ

AU - Kummu, O

AU - Gylling, H

AU - Hyotylainen, T

AU - Oresic, M

AU - Tolonen, A

AU - Hautajarvi, H

AU - Savolainen, MJ

AU - Ala-Korpela, M

AU - Hukkanen, J

AU - Hakkola, J

PY - 2021/6

Y1 - 2021/6

KW - cholesterol

KW - hypercholesterolemia

KW - lathosterol

KW - LDL

KW - PCSK9

KW - PXR

KW - SREBP2

KW - HMG-COA REDUCTASE

KW - MAGNETIC-RESONANCE METABOLOMICS

KW - BILE-ACID SYNTHESIS

KW - GLUCOSE-HOMEOSTASIS

KW - INSULIN-RESISTANCE

KW - CHOLESTEROL LEVELS

KW - ENZYME-INDUCTION

KW - CONCISE GUIDE

KW - SERUM-LEVELS

KW - METABOLISM

KW - 3111 Biomedicine

U2 - 10.1111/bph.15433

DO - 10.1111/bph.15433

M3 - Article

SN - 0007-1188

VL - 178

SP - 2461

EP - 2481

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 12

ER -