Adenoviral Delivery of Tumor Necrosis Factor-alpha and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

Mikko Siurala; Riikka Havunen; Dipongkor Saha; Dave Lumen; Anu J. Airaksinen; Siri Tähtinen; Victor Cervera-Carrascon; Simona Bramante; Suvi Parviainen; Markus Vaha-Koskela; Anna Kanerva; Akseli  Hemminki

doi:10.1038/mt.2016.137

Adenoviral Delivery of Tumor Necrosis Factor-alpha and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

Mikko Siurala, Riikka Havunen, Dipongkor Saha, Dave Lumen, Anu J. Airaksinen, Siri Tähtinen, Victor Cervera-Carrascon, Simona Bramante, Suvi Parviainen, Markus Vaha-Koskela, Anna Kanerva, Akseli Hemminki

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Molecular therapy
Volume	24
Issue number	8
Pages (from-to)	1435-1443
Number of pages	9
ISSN	1525-0016
DOIs	https://doi.org/10.1038/mt.2016.137
Publication status	Published - Aug 2016
MoE publication type	A1 Journal article-refereed

Fields of Science

ONCOLYTIC ADENOVIRUS
TNF-ALPHA
T-CELLS
IN-VIVO
RECOMBINANT INTERLEUKIN-2
GENE-TRANSFER
CANCER-IMMUNOTHERAPY
BREAST-CANCER
SOLID TUMORS
GM-CSF
3111 Biomedicine
3122 Cancers

Access to Document

10.1038/mt.2016.137

In vivo small animal SPECT/CT Imaging Laboratory
J. Arturo Garcia Horsman (Manager)
Faculty of Pharmacy
Facility/equipment: Equipment

Cite this

Siurala, M., Havunen, R., Saha, D., Lumen, D., Airaksinen, A. J., Tähtinen, S., Cervera-Carrascon, V., Bramante, S., Parviainen, S., Vaha-Koskela, M., Kanerva, A., & Hemminki, A. (2016). Adenoviral Delivery of Tumor Necrosis Factor-alpha and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma. Molecular therapy, 24(8), 1435-1443. https://doi.org/10.1038/mt.2016.137

@article{6718e71664c84b14870373f5d9736dd2,

title = "Adenoviral Delivery of Tumor Necrosis Factor-alpha and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma",

keywords = "ONCOLYTIC ADENOVIRUS, TNF-ALPHA, T-CELLS, IN-VIVO, RECOMBINANT INTERLEUKIN-2, GENE-TRANSFER, CANCER-IMMUNOTHERAPY, BREAST-CANCER, SOLID TUMORS, GM-CSF, 3111 Biomedicine, 3122 Cancers",

author = "Mikko Siurala and Riikka Havunen and Dipongkor Saha and Dave Lumen and Airaksinen, {Anu J.} and Siri T{\"a}htinen and Victor Cervera-Carrascon and Simona Bramante and Suvi Parviainen and Markus Vaha-Koskela and Anna Kanerva and Akseli Hemminki",

year = "2016",

month = aug,

doi = "10.1038/mt.2016.137",

language = "English",

volume = "24",

pages = "1435--1443",

journal = "Molecular therapy",

issn = "1525-0016",

publisher = "Cell Press",

number = "8",

}

Siurala, M, Havunen, R, Saha, D, Lumen, D , Airaksinen, AJ, Tähtinen, S, Cervera-Carrascon, V, Bramante, S, Parviainen, S, Vaha-Koskela, M , Kanerva, A & Hemminki, A 2016, 'Adenoviral Delivery of Tumor Necrosis Factor-alpha and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma', Molecular therapy, vol. 24, no. 8, pp. 1435-1443. https://doi.org/10.1038/mt.2016.137

TY - JOUR

T1 - Adenoviral Delivery of Tumor Necrosis Factor-alpha and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

AU - Siurala, Mikko

AU - Havunen, Riikka

AU - Saha, Dipongkor

AU - Lumen, Dave

AU - Airaksinen, Anu J.

AU - Tähtinen, Siri

AU - Cervera-Carrascon, Victor

AU - Bramante, Simona

AU - Parviainen, Suvi

AU - Vaha-Koskela, Markus

AU - Kanerva, Anna

AU - Hemminki, Akseli

PY - 2016/8

Y1 - 2016/8

KW - ONCOLYTIC ADENOVIRUS

KW - TNF-ALPHA

KW - T-CELLS

KW - IN-VIVO

KW - RECOMBINANT INTERLEUKIN-2

KW - GENE-TRANSFER

KW - CANCER-IMMUNOTHERAPY

KW - BREAST-CANCER

KW - SOLID TUMORS

KW - GM-CSF

KW - 3111 Biomedicine

KW - 3122 Cancers

U2 - 10.1038/mt.2016.137

DO - 10.1038/mt.2016.137

M3 - Article

VL - 24

SP - 1435

EP - 1443

JO - Molecular therapy

JF - Molecular therapy

SN - 1525-0016

IS - 8

ER -

Adenoviral Delivery of Tumor Necrosis Factor-alpha and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

Fields of Science

Access to Document

Equipment

In vivo small animal SPECT/CT Imaging Laboratory

Cite this