Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer

James H. A. Clubb; Tatiana V. Kudling; Camilla Heinioe; Saru Basnet; Santeri Pakola; Victor Cervera Carrascon; Joao Manuel Santos; Dafne C. A. Quixabeira; Riikka Havunen; Suvi Sorsa; Vincent Zheng; Tuula Salo; Leif Bäck; Katri Aro; Sanni Tulokas; Venla Loimu; Akseli Hemminki

doi:10.3389/fimmu.2022.794251

Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer

James H. A. Clubb, Tatiana V. Kudling, Camilla Heinioe, Saru Basnet, Santeri Pakola, Victor Cervera Carrascon, Joao Manuel Santos, Dafne C. A. Quixabeira, Riikka Havunen, Suvi Sorsa, Vincent Zheng, Tuula Salo, Leif Bäck, Katri Aro, Sanni Tulokas, Venla Loimu, Akseli Hemminki

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	794251
Journal	Frontiers in Immunology
Volume	13
Number of pages	17
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2022.794251
Publication status	Published - 7 Mar 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

adenovirus
immune checkpoint inhibitor
head and neck cancer
immunotherapy
tertiary lymphoid neogenesis
TNFa
IL2
oncolytic virotherapy
SQUAMOUS-CELL CARCINOMA
INTRAEPITHELIAL NEOPLASIA GRADE-2
TNF-ALPHA
THERAPY
RECURRENT
IMMUNOTHERAPY
RESISTANCE
SURVIVAL
RISK
3111 Biomedicine
3122 Cancers

Access to Document

10.3389/fimmu.2022.794251

fimmu-13-794251Final published version, 11.7 MBLicence: CC BY

Cite this

Clubb, J. H. A., Kudling, T. V., Heinioe, C., Basnet, S., Pakola, S., Cervera Carrascon, V., Santos, J. M., Quixabeira, D. C. A., Havunen, R., Sorsa, S., Zheng, V., Salo, T., Bäck, L., Aro, K., Tulokas, S., Loimu, V., & Hemminki, A. (2022). Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer. Frontiers in Immunology, 13, Article 794251. https://doi.org/10.3389/fimmu.2022.794251

@article{656f446622fe4ab09bc5dae704b6e895,

title = "Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer",

keywords = "adenovirus, immune checkpoint inhibitor, head and neck cancer, immunotherapy, tertiary lymphoid neogenesis, TNFa, IL2, oncolytic virotherapy, SQUAMOUS-CELL CARCINOMA, INTRAEPITHELIAL NEOPLASIA GRADE-2, TNF-ALPHA, THERAPY, RECURRENT, IMMUNOTHERAPY, RESISTANCE, SURVIVAL, RISK, 3111 Biomedicine, 3122 Cancers",

author = "Clubb, {James H. A.} and Kudling, {Tatiana V.} and Camilla Heinioe and Saru Basnet and Santeri Pakola and {Cervera Carrascon}, Victor and Santos, {Joao Manuel} and Quixabeira, {Dafne C. A.} and Riikka Havunen and Suvi Sorsa and Vincent Zheng and Tuula Salo and Leif B{\"a}ck and Katri Aro and Sanni Tulokas and Venla Loimu and Akseli Hemminki",

year = "2022",

month = mar,

day = "7",

doi = "10.3389/fimmu.2022.794251",

language = "English",

volume = "13",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media SA",

}

Clubb, JHA, Kudling, TV, Heinioe, C, Basnet, S, Pakola, S, Cervera Carrascon, V, Santos, JM, Quixabeira, DCA, Havunen, R, Sorsa, S, Zheng, V , Salo, T , Bäck, L , Aro, K , Tulokas, S , Loimu, V & Hemminki, A 2022, 'Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer', Frontiers in Immunology, vol. 13, 794251. https://doi.org/10.3389/fimmu.2022.794251

Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer. / Clubb, James H. A.; Kudling, Tatiana V.; Heinioe, Camilla et al.
In: Frontiers in Immunology, Vol. 13, 794251, 07.03.2022.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer

AU - Clubb, James H. A.

AU - Kudling, Tatiana V.

AU - Heinioe, Camilla

AU - Basnet, Saru

AU - Pakola, Santeri

AU - Cervera Carrascon, Victor

AU - Santos, Joao Manuel

AU - Quixabeira, Dafne C. A.

AU - Havunen, Riikka

AU - Sorsa, Suvi

AU - Zheng, Vincent

AU - Salo, Tuula

AU - Bäck, Leif

AU - Aro, Katri

AU - Tulokas, Sanni

AU - Loimu, Venla

AU - Hemminki, Akseli

PY - 2022/3/7

Y1 - 2022/3/7

KW - adenovirus

KW - immune checkpoint inhibitor

KW - head and neck cancer

KW - immunotherapy

KW - tertiary lymphoid neogenesis

KW - TNFa

KW - IL2

KW - oncolytic virotherapy

KW - SQUAMOUS-CELL CARCINOMA

KW - INTRAEPITHELIAL NEOPLASIA GRADE-2

KW - TNF-ALPHA

KW - THERAPY

KW - RECURRENT

KW - IMMUNOTHERAPY

KW - RESISTANCE

KW - SURVIVAL

KW - RISK

KW - 3111 Biomedicine

KW - 3122 Cancers

U2 - 10.3389/fimmu.2022.794251

DO - 10.3389/fimmu.2022.794251

M3 - Article

SN - 1664-3224

VL - 13

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 794251

ER -