Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional study

Antero Ylänen; Juhani Isojärvi; Antti Virtanen; Helena Leijon; Tiina Vesterinen; Aapo L. Aro; Heini Huhtala; Eeva Kokko; Ilkka Pörsti; Marianna Viukari; Pasi I. Nevalainen; Niina Matikainen

doi:10.1016/j.lanepe.2025.101226

Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional study

Antero Ylänen
, Juhani Isojärvi
, Antti Virtanen
, Helena Leijon
, Tiina Vesterinen
, Aapo L. Aro
, Heini Huhtala
, Eeva Kokko
, Ilkka Pörsti
, Marianna Viukari
, Pasi I. Nevalainen
, Niina Matikainen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	101226
Journal	The Lancet Regional Health - Europe
Volume	51
Number of pages	11
ISSN	2666-7762
DOIs	https://doi.org/10.1016/j.lanepe.2025.101226
Publication status	Published - Apr 2025
MoE publication type	A1 Journal article-refereed

Bibliographical note

Publisher Copyright:
© 2025 The Author(s)

Fields of Science

Aldosterone synthase
Aldosterone-producing adenoma
Aldosterone-producing micronodule
Aldosterone-producing nodule
CYP11B2
Histopathological classification
Hypertension
Pheochromocytoma
Primary aldosteronism
Sudden death
3142 Public health care science, environmental and occupational health
3141 Health care science

Access to Document

10.1016/j.lanepe.2025.101226

1-s2.0-S2666776225000183-mainFinal published version, 493 KBLicence: CC BY

Cite this

Ylänen, A., Isojärvi, J., Virtanen, A., Leijon, H., Vesterinen, T., Aro, A. L., Huhtala, H., Kokko, E., Pörsti, I., Viukari, M., Nevalainen, P. I., & Matikainen, N. (2025). Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional study. The Lancet Regional Health - Europe, 51, Article 101226. https://doi.org/10.1016/j.lanepe.2025.101226

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keywords = "Aldosterone synthase, Aldosterone-producing adenoma, Aldosterone-producing micronodule, Aldosterone-producing nodule, CYP11B2, Histopathological classification, Hypertension, Pheochromocytoma, Primary aldosteronism, Sudden death, 3142 Public health care science, environmental and occupational health, 3141 Health care science",

author = "Antero Yl{\"a}nen and Juhani Isoj{\"a}rvi and Antti Virtanen and Helena Leijon and Tiina Vesterinen and Aro, \{Aapo L.\} and Heini Huhtala and Eeva Kokko and Ilkka P{\"o}rsti and Marianna Viukari and Nevalainen, \{Pasi I.\} and Niina Matikainen",

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year = "2025",

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doi = "10.1016/j.lanepe.2025.101226",

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journal = "The Lancet Regional Health - Europe",

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Ylänen, A, Isojärvi, J, Virtanen, A, Leijon, H , Vesterinen, T , Aro, AL, Huhtala, H, Kokko, E, Pörsti, I, Viukari, M, Nevalainen, PI & Matikainen, N 2025, 'Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional study', The Lancet Regional Health - Europe, vol. 51, 101226. https://doi.org/10.1016/j.lanepe.2025.101226

TY - JOUR

T1 - Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death

T2 - a cross-sectional study

AU - Ylänen, Antero

AU - Isojärvi, Juhani

AU - Virtanen, Antti

AU - Leijon, Helena

AU - Vesterinen, Tiina

AU - Aro, Aapo L.

AU - Huhtala, Heini

AU - Kokko, Eeva

AU - Pörsti, Ilkka

AU - Viukari, Marianna

AU - Nevalainen, Pasi I.

AU - Matikainen, Niina

PY - 2025/4

Y1 - 2025/4

KW - Aldosterone synthase

KW - Aldosterone-producing adenoma

KW - Aldosterone-producing micronodule

KW - Aldosterone-producing nodule

KW - CYP11B2

KW - Histopathological classification

KW - Hypertension

KW - Pheochromocytoma

KW - Primary aldosteronism

KW - Sudden death

KW - 3142 Public health care science, environmental and occupational health

KW - 3141 Health care science

U2 - 10.1016/j.lanepe.2025.101226

DO - 10.1016/j.lanepe.2025.101226

M3 - Article

AN - SCOPUS:85216979049

SN - 2666-7762

VL - 51

JO - The Lancet Regional Health - Europe

JF - The Lancet Regional Health - Europe

M1 - 101226

ER -