Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Ruoyu Cheng, Lili Liu, Yi Xiang, Yong Lu, Lianfu Deng, Hongbo Zhang, Hélder A. Santos, Wenguo Cui

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes’ biocompatibility and scaffolds’ strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.
Original languageEnglish
JournalBiomaterials
Volume232
Pages (from-to)119706
Number of pages17
ISSN0142-9612
DOIs
Publication statusPublished - Feb 2020
MoE publication typeA2 Review article in a scientific journal

Cite this

Cheng, Ruoyu ; Liu, Lili ; Xiang, Yi ; Lu, Yong ; Deng, Lianfu ; Zhang, Hongbo ; Santos, Hélder A. ; Cui, Wenguo. / Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications. In: Biomaterials. 2020 ; Vol. 232. pp. 119706.
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abstract = "Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes’ biocompatibility and scaffolds’ strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.",
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Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications. / Cheng, Ruoyu; Liu, Lili; Xiang, Yi; Lu, Yong; Deng, Lianfu; Zhang, Hongbo; Santos, Hélder A.; Cui, Wenguo.

In: Biomaterials, Vol. 232, 02.2020, p. 119706.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

AU - Cheng, Ruoyu

AU - Liu, Lili

AU - Xiang, Yi

AU - Lu, Yong

AU - Deng, Lianfu

AU - Zhang, Hongbo

AU - Santos, Hélder A.

AU - Cui, Wenguo

PY - 2020/2

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N2 - Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes’ biocompatibility and scaffolds’ strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.

AB - Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes’ biocompatibility and scaffolds’ strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.

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