Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children

Bronner P. Goncalves, Helmi Pett, Alfred B. Tiono, Daryl Murry, Sodiomon B. Sirima, Mikko Niemi, Teun Bousema, Chris Drakeley, Rob ter Heine

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article number02590
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number5
Number of pages11
ISSN0066-4804
DOIs
Publication statusPublished - May 2017
MoE publication typeA1 Journal article-refereed

Fields of Science

  • pharmacokinetics
  • primaquine
  • Plasmodium falciparum
  • CYP2D6
  • PLASMODIUM-VIVAX MALARIA
  • SINGLE-DOSE PRIMAQUINE
  • NEW-GUINEAN CHILDREN
  • ARTEMETHER-LUMEFANTRINE
  • DIHYDROARTEMISININ-PIPERAQUINE
  • UNCOMPLICATED MALARIA
  • FALCIPARUM-MALARIA
  • CONTROLLED-TRIAL
  • RADICAL CURE
  • DOUBLE-BLIND
  • 3111 Biomedicine
  • 3123 Gynaecology and paediatrics

Cite this

Goncalves, Bronner P. ; Pett, Helmi ; Tiono, Alfred B. ; Murry, Daryl ; Sirima, Sodiomon B. ; Niemi, Mikko ; Bousema, Teun ; Drakeley, Chris ; ter Heine, Rob. / Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children. In: Antimicrobial Agents and Chemotherapy. 2017 ; Vol. 61, No. 5.
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title = "Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children",
keywords = "pharmacokinetics, primaquine, Plasmodium falciparum, CYP2D6, PLASMODIUM-VIVAX MALARIA, SINGLE-DOSE PRIMAQUINE, NEW-GUINEAN CHILDREN, ARTEMETHER-LUMEFANTRINE, DIHYDROARTEMISININ-PIPERAQUINE, UNCOMPLICATED MALARIA, FALCIPARUM-MALARIA, CONTROLLED-TRIAL, RADICAL CURE, DOUBLE-BLIND, 3111 Biomedicine, 3123 Gynaecology and paediatrics",
author = "Goncalves, {Bronner P.} and Helmi Pett and Tiono, {Alfred B.} and Daryl Murry and Sirima, {Sodiomon B.} and Mikko Niemi and Teun Bousema and Chris Drakeley and {ter Heine}, Rob",
year = "2017",
month = "5",
doi = "10.1128/AAC.02590-16",
language = "English",
volume = "61",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "5",

}

Goncalves, BP, Pett, H, Tiono, AB, Murry, D, Sirima, SB, Niemi, M, Bousema, T, Drakeley, C & ter Heine, R 2017, 'Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children', Antimicrobial Agents and Chemotherapy, vol. 61, no. 5, 02590. https://doi.org/10.1128/AAC.02590-16

Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children. / Goncalves, Bronner P.; Pett, Helmi; Tiono, Alfred B.; Murry, Daryl; Sirima, Sodiomon B.; Niemi, Mikko; Bousema, Teun; Drakeley, Chris; ter Heine, Rob.

In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 5, 02590, 05.2017.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children

AU - Goncalves, Bronner P.

AU - Pett, Helmi

AU - Tiono, Alfred B.

AU - Murry, Daryl

AU - Sirima, Sodiomon B.

AU - Niemi, Mikko

AU - Bousema, Teun

AU - Drakeley, Chris

AU - ter Heine, Rob

PY - 2017/5

Y1 - 2017/5

KW - pharmacokinetics

KW - primaquine

KW - Plasmodium falciparum

KW - CYP2D6

KW - PLASMODIUM-VIVAX MALARIA

KW - SINGLE-DOSE PRIMAQUINE

KW - NEW-GUINEAN CHILDREN

KW - ARTEMETHER-LUMEFANTRINE

KW - DIHYDROARTEMISININ-PIPERAQUINE

KW - UNCOMPLICATED MALARIA

KW - FALCIPARUM-MALARIA

KW - CONTROLLED-TRIAL

KW - RADICAL CURE

KW - DOUBLE-BLIND

KW - 3111 Biomedicine

KW - 3123 Gynaecology and paediatrics

U2 - 10.1128/AAC.02590-16

DO - 10.1128/AAC.02590-16

M3 - Article

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 5

M1 - 02590

ER -