Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Olli Dufva; Matti Kankainen; Tiina Kelkka; Nodoka Sekiguchi; Shady Adnan Awad; Samuli Eldfors; Bhagwan Yadav; Heikki Kuusanmäki; Disha Malani; Emma I. Andersson; Paavo Pietarinen; Leena Saikko; Panu E. Kovanen; Teija Ojala; Dean A. Lee; Thomas P. Loughran; Hideyuki Nakazawa; Junji Suzumiya; Ritsuro Suzuki; Young Hyeh Ko; Won Seog Kim; Shih-Sung Chuang; Tero Aittokallio; Wing C. Chan; Koichi Ohshima; Fumihiro Ishida; Satu Mustjoki

doi:10.1038/s41467-018-03987-2

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Olli Dufva, Matti Kankainen, Tiina Kelkka, Nodoka Sekiguchi, Shady Adnan Awad, Samuli Eldfors, Bhagwan Yadav, Heikki Kuusanmäki, Disha Malani, Emma I. Andersson, Paavo Pietarinen, Leena Saikko, Panu E. Kovanen, Teija Ojala, Dean A. Lee, Thomas P. Loughran, Hideyuki Nakazawa, Junji Suzumiya, Ritsuro Suzuki, Young Hyeh KoWon Seog Kim, Shih-Sung Chuang, Tero Aittokallio, Wing C. Chan, Koichi Ohshima, Fumihiro Ishida, Satu Mustjoki

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	1567
Journal	Nature Communications
Volume	9
Number of pages	12
ISSN	2041-1723
DOIs	https://doi.org/10.1038/s41467-018-03987-2
Publication status	Published - 19 Apr 2018
MoE publication type	A1 Journal article-refereed

Fields of Science

EPSTEIN-BARR-VIRUS
DIFFERENTIAL EXPRESSION ANALYSIS
GRANULAR LYMPHOCYTE LEUKEMIA
DNA-SEQUENCING DATA
GAMMA-DELTA-T
NASAL TYPE
NK CELLS
LYMPHOPROLIFERATIVE DISORDERS
MYELOPROLIFERATIVE NEOPLASMS
L-ASPARAGINASE
3122 Cancers

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10.1038/s41467-018-03987-2

AggressiveFinal published version, 1.15 MBLicence: CC BY

Cite this

Dufva, O., Kankainen, M., Kelkka, T., Sekiguchi, N., Awad, S. A., Eldfors, S., Yadav, B., Kuusanmäki, H., Malani, D., Andersson, E. I., Pietarinen, P., Saikko, L., Kovanen, P. E., Ojala, T., Lee, D. A., Loughran, T. P., Nakazawa, H., Suzumiya, J., Suzuki, R., ... Mustjoki, S. (2018). Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target. Nature Communications, 9, [1567]. https://doi.org/10.1038/s41467-018-03987-2

@article{336f50439d1d49fead389dafcbc1b5f0,

title = "Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target",

keywords = "EPSTEIN-BARR-VIRUS, DIFFERENTIAL EXPRESSION ANALYSIS, GRANULAR LYMPHOCYTE LEUKEMIA, DNA-SEQUENCING DATA, GAMMA-DELTA-T, NASAL TYPE, NK CELLS, LYMPHOPROLIFERATIVE DISORDERS, MYELOPROLIFERATIVE NEOPLASMS, L-ASPARAGINASE, 3122 Cancers",

author = "Olli Dufva and Matti Kankainen and Tiina Kelkka and Nodoka Sekiguchi and Awad, {Shady Adnan} and Samuli Eldfors and Bhagwan Yadav and Heikki Kuusanm{\"a}ki and Disha Malani and Andersson, {Emma I.} and Paavo Pietarinen and Leena Saikko and Kovanen, {Panu E.} and Teija Ojala and Lee, {Dean A.} and Loughran, {Thomas P.} and Hideyuki Nakazawa and Junji Suzumiya and Ritsuro Suzuki and Ko, {Young Hyeh} and Kim, {Won Seog} and Shih-Sung Chuang and Tero Aittokallio and Chan, {Wing C.} and Koichi Ohshima and Fumihiro Ishida and Satu Mustjoki",

year = "2018",

month = apr,

day = "19",

doi = "10.1038/s41467-018-03987-2",

language = "English",

volume = "9",

journal = "Nature Communications",

issn = "2041-1723",

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Dufva, O, Kankainen, M , Kelkka, T, Sekiguchi, N, Awad, SA , Eldfors, S , Yadav, B , Kuusanmäki, H, Malani, D, Andersson, EI, Pietarinen, P, Saikko, L, Kovanen, PE, Ojala, T, Lee, DA, Loughran, TP, Nakazawa, H, Suzumiya, J, Suzuki, R, Ko, YH, Kim, WS, Chuang, S-S, Aittokallio, T, Chan, WC, Ohshima, K, Ishida, F & Mustjoki, S 2018, 'Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target', Nature Communications, vol. 9, 1567. https://doi.org/10.1038/s41467-018-03987-2

TY - JOUR

T1 - Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

AU - Dufva, Olli

AU - Kankainen, Matti

AU - Kelkka, Tiina

AU - Sekiguchi, Nodoka

AU - Awad, Shady Adnan

AU - Eldfors, Samuli

AU - Yadav, Bhagwan

AU - Kuusanmäki, Heikki

AU - Malani, Disha

AU - Andersson, Emma I.

AU - Pietarinen, Paavo

AU - Saikko, Leena

AU - Kovanen, Panu E.

AU - Ojala, Teija

AU - Lee, Dean A.

AU - Loughran, Thomas P.

AU - Nakazawa, Hideyuki

AU - Suzumiya, Junji

AU - Suzuki, Ritsuro

AU - Ko, Young Hyeh

AU - Kim, Won Seog

AU - Chuang, Shih-Sung

AU - Aittokallio, Tero

AU - Chan, Wing C.

AU - Ohshima, Koichi

AU - Ishida, Fumihiro

AU - Mustjoki, Satu

PY - 2018/4/19

Y1 - 2018/4/19

KW - EPSTEIN-BARR-VIRUS

KW - DIFFERENTIAL EXPRESSION ANALYSIS

KW - GRANULAR LYMPHOCYTE LEUKEMIA

KW - DNA-SEQUENCING DATA

KW - GAMMA-DELTA-T

KW - NASAL TYPE

KW - NK CELLS

KW - LYMPHOPROLIFERATIVE DISORDERS

KW - MYELOPROLIFERATIVE NEOPLASMS

KW - L-ASPARAGINASE

KW - 3122 Cancers

U2 - 10.1038/s41467-018-03987-2

DO - 10.1038/s41467-018-03987-2

M3 - Article

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 1567

ER -