ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors

Katja Kaipio, Ping Chen, Pia Roering, Kaisa Huhtinen, Piia Mikkonen, Päivi Östling, Laura Lehtinen, Naziha Mansuri, Taina Korpela, Swapnil Potdar, Johanna Hynninen, Annika Auranen, Seija Grénman, Krister Wennerberg, Sampsa Hautaniemi, Olli Carpén

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Pathology
Volume250
Issue number2
Number of pages11
ISSN0022-3417
DOIs
Publication statusPublished - Feb 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3122 Cancers
  • Ovarian cancer
  • stem-like cell
  • patient derived cell line
  • survival
  • drug sensitivity
  • CELLS
  • CONTRIBUTE
  • BMI-1
  • ovarian cancer
  • ALDEHYDE DEHYDROGENASE
  • MARKER
  • IDENTIFICATION
  • patient-derived cell line
  • MICROENVIRONMENT
  • EXPRESSION
  • EPITHELIAL OVARIAN
  • AURORA

Cite this

Kaipio, Katja ; Chen, Ping ; Roering, Pia ; Huhtinen, Kaisa ; Mikkonen, Piia ; Östling, Päivi ; Lehtinen, Laura ; Mansuri, Naziha ; Korpela, Taina ; Potdar, Swapnil ; Hynninen, Johanna ; Auranen, Annika ; Grénman, Seija ; Wennerberg, Krister ; Hautaniemi, Sampsa ; Carpén, Olli. / ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors. In: Journal of Pathology. 2020 ; Vol. 250, No. 2.
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title = "ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors",
keywords = "3122 Cancers, Ovarian cancer, stem-like cell, patient derived cell line, survival, drug sensitivity, CELLS, CONTRIBUTE, BMI-1, ovarian cancer, ALDEHYDE DEHYDROGENASE, MARKER, IDENTIFICATION, patient-derived cell line, MICROENVIRONMENT, EXPRESSION, EPITHELIAL OVARIAN, AURORA",
author = "Katja Kaipio and Ping Chen and Pia Roering and Kaisa Huhtinen and Piia Mikkonen and P{\"a}ivi {\"O}stling and Laura Lehtinen and Naziha Mansuri and Taina Korpela and Swapnil Potdar and Johanna Hynninen and Annika Auranen and Seija Gr{\'e}nman and Krister Wennerberg and Sampsa Hautaniemi and Olli Carp{\'e}n",
year = "2020",
month = "2",
doi = "10.1002/path.5356",
language = "English",
volume = "250",
journal = "Journal of Pathology",
issn = "0022-3417",
publisher = "John Wiley & Sons Ltd.",
number = "2",

}

ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors. / Kaipio, Katja; Chen, Ping; Roering, Pia; Huhtinen, Kaisa; Mikkonen, Piia; Östling, Päivi; Lehtinen, Laura; Mansuri, Naziha; Korpela, Taina; Potdar, Swapnil; Hynninen, Johanna; Auranen, Annika; Grénman, Seija; Wennerberg, Krister; Hautaniemi, Sampsa; Carpén, Olli.

In: Journal of Pathology, Vol. 250, No. 2, 02.2020.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors

AU - Kaipio, Katja

AU - Chen, Ping

AU - Roering, Pia

AU - Huhtinen, Kaisa

AU - Mikkonen, Piia

AU - Östling, Päivi

AU - Lehtinen, Laura

AU - Mansuri, Naziha

AU - Korpela, Taina

AU - Potdar, Swapnil

AU - Hynninen, Johanna

AU - Auranen, Annika

AU - Grénman, Seija

AU - Wennerberg, Krister

AU - Hautaniemi, Sampsa

AU - Carpén, Olli

PY - 2020/2

Y1 - 2020/2

KW - 3122 Cancers

KW - Ovarian cancer

KW - stem-like cell

KW - patient derived cell line

KW - survival

KW - drug sensitivity

KW - CELLS

KW - CONTRIBUTE

KW - BMI-1

KW - ovarian cancer

KW - ALDEHYDE DEHYDROGENASE

KW - MARKER

KW - IDENTIFICATION

KW - patient-derived cell line

KW - MICROENVIRONMENT

KW - EXPRESSION

KW - EPITHELIAL OVARIAN

KW - AURORA

U2 - 10.1002/path.5356

DO - 10.1002/path.5356

M3 - Article

VL - 250

JO - Journal of Pathology

JF - Journal of Pathology

SN - 0022-3417

IS - 2

ER -