Abstract
Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
Original language | English |
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Journal | Biomaterials Science |
Volume | 8 |
Issue number | 12 |
Pages (from-to) | 3270-3277 |
Number of pages | 8 |
ISSN | 2047-4830 |
DOIs | |
Publication status | Published - 21 Jun 2020 |
MoE publication type | A1 Journal article-refereed |
Fields of Science
- BARRIER
- BILE-SALTS
- CELL
- CHITOSAN
- DRUG-DELIVERY
- LIPOSOMES
- MOLECULAR-WEIGHT
- NANOPARTICLES
- STABILITY
- VITRO
- 317 Pharmacy