Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2

Wei Wang, Aino-Liisa Mutka, Ursula Prosenc Zmrzljak, Damjana Rozman, Heikki Tanila, Helena Gylling, Anne M. Remes, Henri J. Huttunen, Elina Ikonen

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalFASEB Journal
Volume28
Issue number2
Pages (from-to)849-860
Number of pages12
ISSN0892-6638
DOIs
Publication statusPublished - Feb 2014
MoE publication typeA1 Journal article-refereed

Fields of Science

  • LDL uptake
  • APP processing
  • ALZHEIMERS-DISEASE
  • SURROGATE MARKERS
  • SITE-1 PROTEASE
  • LIPID RAFTS
  • APP
  • METABOLISM
  • TRANSPORT
  • ABSORPTION
  • PRESENILIN
  • SECRETASE
  • 3121 Internal medicine
  • 3124 Neurology and psychiatry

Cite this

Wang, Wei ; Mutka, Aino-Liisa ; Zmrzljak, Ursula Prosenc ; Rozman, Damjana ; Tanila, Heikki ; Gylling, Helena ; Remes, Anne M. ; Huttunen, Henri J. ; Ikonen, Elina. / Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2. In: FASEB Journal. 2014 ; Vol. 28, No. 2. pp. 849-860.
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title = "Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2",
keywords = "LDL uptake, APP processing, ALZHEIMERS-DISEASE, SURROGATE MARKERS, SITE-1 PROTEASE, LIPID RAFTS, APP, METABOLISM, TRANSPORT, ABSORPTION, PRESENILIN, SECRETASE, 3121 Internal medicine, 3124 Neurology and psychiatry",
author = "Wei Wang and Aino-Liisa Mutka and Zmrzljak, {Ursula Prosenc} and Damjana Rozman and Heikki Tanila and Helena Gylling and Remes, {Anne M.} and Huttunen, {Henri J.} and Elina Ikonen",
year = "2014",
month = "2",
doi = "10.1096/fj.13-239301",
language = "English",
volume = "28",
pages = "849--860",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "Federation of American Societies for Experimental Biology",
number = "2",

}

Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2. / Wang, Wei; Mutka, Aino-Liisa; Zmrzljak, Ursula Prosenc; Rozman, Damjana; Tanila, Heikki; Gylling, Helena; Remes, Anne M.; Huttunen, Henri J.; Ikonen, Elina.

In: FASEB Journal, Vol. 28, No. 2, 02.2014, p. 849-860.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2

AU - Wang, Wei

AU - Mutka, Aino-Liisa

AU - Zmrzljak, Ursula Prosenc

AU - Rozman, Damjana

AU - Tanila, Heikki

AU - Gylling, Helena

AU - Remes, Anne M.

AU - Huttunen, Henri J.

AU - Ikonen, Elina

PY - 2014/2

Y1 - 2014/2

KW - LDL uptake

KW - APP processing

KW - ALZHEIMERS-DISEASE

KW - SURROGATE MARKERS

KW - SITE-1 PROTEASE

KW - LIPID RAFTS

KW - APP

KW - METABOLISM

KW - TRANSPORT

KW - ABSORPTION

KW - PRESENILIN

KW - SECRETASE

KW - 3121 Internal medicine

KW - 3124 Neurology and psychiatry

U2 - 10.1096/fj.13-239301

DO - 10.1096/fj.13-239301

M3 - Article

VL - 28

SP - 849

EP - 860

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 2

ER -