An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

Jonna Saarimaki-Vire; Diego Balboa; Mark A. Russell; Juha Saarikettu; Matias Kinnunen; Salla Keskitalo; Amrinder Malhi; Cristina Valensisi; Colin Andrus; Solja Eurola; Heli Grym; Jarkko Ustinov; Kirmo Wartiovaara; R. David Hawkins; Olli Silvennoinen; Markku Varjosalo; Noel G. Morgan; Timo Otonkoski

doi:10.1016/j.celrep.2017.03.055

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

Jonna Saarimaki-Vire, Diego Balboa, Mark A. Russell, Juha Saarikettu, Matias Kinnunen, Salla Keskitalo, Amrinder Malhi, Cristina Valensisi, Colin Andrus, Solja Eurola, Heli Grym, Jarkko Ustinov, Kirmo Wartiovaara, R. David Hawkins, Olli Silvennoinen, Markku Varjosalo, Noel G. Morgan, Timo Otonkoski

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Cell Reports
Volume	19
Issue number	2
Pages (from-to)	281-294
Number of pages	14
ISSN	2211-1247
DOIs	https://doi.org/10.1016/j.celrep.2017.03.055
Publication status	Published - 11 Apr 2017
MoE publication type	A1 Journal article-refereed

Fields of Science

PLURIPOTENT STEM-CELLS
BETA-LIKE CELLS
IN-VITRO
ENDOCRINE PANCREAS
PROGENITOR CELLS
KNOCKOUT MICE
GENERATION
NEUROGENIN3
EXPRESSION
REVEALS
3111 Biomedicine
1182 Biochemistry, cell and molecular biology

Access to Document

10.1016/j.celrep.2017.03.055

An Activating STAT3 Mutation Causes NeonatalFinal published version, 4.85 MBLicence: CC BY-NC-ND

Cite this

Saarimaki-Vire, J., Balboa, D., Russell, M. A., Saarikettu, J., Kinnunen, M., Keskitalo, S., Malhi, A., Valensisi, C., Andrus, C., Eurola, S., Grym, H., Ustinov, J., Wartiovaara, K., Hawkins, R. D., Silvennoinen, O., Varjosalo, M., Morgan, N. G., & Otonkoski, T. (2017). An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Reports, 19(2), 281-294. https://doi.org/10.1016/j.celrep.2017.03.055

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title = "An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation",

keywords = "PLURIPOTENT STEM-CELLS, BETA-LIKE CELLS, IN-VITRO, ENDOCRINE PANCREAS, PROGENITOR CELLS, KNOCKOUT MICE, GENERATION, NEUROGENIN3, EXPRESSION, REVEALS, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology",

author = "Jonna Saarimaki-Vire and Diego Balboa and Russell, {Mark A.} and Juha Saarikettu and Matias Kinnunen and Salla Keskitalo and Amrinder Malhi and Cristina Valensisi and Colin Andrus and Solja Eurola and Heli Grym and Jarkko Ustinov and Kirmo Wartiovaara and Hawkins, {R. David} and Olli Silvennoinen and Markku Varjosalo and Morgan, {Noel G.} and Timo Otonkoski",

year = "2017",

month = apr,

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doi = "10.1016/j.celrep.2017.03.055",

language = "English",

volume = "19",

pages = "281--294",

journal = "Cell Reports",

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publisher = "Cell Press",

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Saarimaki-Vire, J , Balboa, D, Russell, MA, Saarikettu, J, Kinnunen, M , Keskitalo, S, Malhi, A, Valensisi, C, Andrus, C, Eurola, S, Grym, H, Ustinov, J , Wartiovaara, K, Hawkins, RD, Silvennoinen, O, Varjosalo, M, Morgan, NG & Otonkoski, T 2017, 'An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation', Cell Reports, vol. 19, no. 2, pp. 281-294. https://doi.org/10.1016/j.celrep.2017.03.055

TY - JOUR

T1 - An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

AU - Saarimaki-Vire, Jonna

AU - Balboa, Diego

AU - Russell, Mark A.

AU - Saarikettu, Juha

AU - Kinnunen, Matias

AU - Keskitalo, Salla

AU - Malhi, Amrinder

AU - Valensisi, Cristina

AU - Andrus, Colin

AU - Eurola, Solja

AU - Grym, Heli

AU - Ustinov, Jarkko

AU - Wartiovaara, Kirmo

AU - Hawkins, R. David

AU - Silvennoinen, Olli

AU - Varjosalo, Markku

AU - Morgan, Noel G.

AU - Otonkoski, Timo

PY - 2017/4/11

Y1 - 2017/4/11

KW - PLURIPOTENT STEM-CELLS

KW - BETA-LIKE CELLS

KW - IN-VITRO

KW - ENDOCRINE PANCREAS

KW - PROGENITOR CELLS

KW - KNOCKOUT MICE

KW - GENERATION

KW - NEUROGENIN3

KW - EXPRESSION

KW - REVEALS

KW - 3111 Biomedicine

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1016/j.celrep.2017.03.055

DO - 10.1016/j.celrep.2017.03.055

M3 - Article

VL - 19

SP - 281

EP - 294

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 2

ER -