An analysis of protocols and publications suggested that most discontinuations of clinical trials were not based on preplanned interim analyses or stopping rules

DISCO Study Grp, Mihaela Stegert, Benjamin Kasenda, Erik von Elm, Matthias Briel, K. A. Tikkinen

Research output: Contribution to journalReview ArticleScientificpeer-review

Original languageEnglish
JournalJournal of Clinical Epidemiology
Volume69
Pages (from-to)152-160
Number of pages9
ISSN0895-4356
DOIs
Publication statusPublished - Jan 2016
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • Randomized controlled trials
  • Protocol
  • Early termination of clinical trials
  • Data monitoring committees
  • Interim analysis
  • Stopping Rules
  • RANDOMIZED-TRIALS
  • 3141 Health care science
  • 3142 Public health care science, environmental and occupational health

Cite this

@article{772b11d2f7214dccbccf2cc4c35f9de6,
title = "An analysis of protocols and publications suggested that most discontinuations of clinical trials were not based on preplanned interim analyses or stopping rules",
keywords = "Randomized controlled trials, Protocol, Early termination of clinical trials, Data monitoring committees, Interim analysis, Stopping Rules, RANDOMIZED-TRIALS, 3141 Health care science, 3142 Public health care science, environmental and occupational health",
author = "{DISCO Study Grp} and Mihaela Stegert and Benjamin Kasenda and {von Elm}, Erik and You, {John J.} and Anette Bluemle and Yuki Tomonaga and Ramon Saccilotto and Alain Amstutz and Theresa Bengough and Matthias Briel and Tikkinen, {K. A.}",
year = "2016",
month = "1",
doi = "10.1016/j.jclinepi.2015.05.023",
language = "English",
volume = "69",
pages = "152--160",
journal = "Journal of Clinical Epidemiology",
issn = "0895-4356",
publisher = "EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC",

}

An analysis of protocols and publications suggested that most discontinuations of clinical trials were not based on preplanned interim analyses or stopping rules. / DISCO Study Grp; Stegert, Mihaela; Kasenda, Benjamin; von Elm, Erik; Briel, Matthias; Tikkinen, K. A. .

In: Journal of Clinical Epidemiology, Vol. 69, 01.2016, p. 152-160.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - An analysis of protocols and publications suggested that most discontinuations of clinical trials were not based on preplanned interim analyses or stopping rules

AU - DISCO Study Grp

AU - Stegert, Mihaela

AU - Kasenda, Benjamin

AU - von Elm, Erik

AU - You, John J.

AU - Bluemle, Anette

AU - Tomonaga, Yuki

AU - Saccilotto, Ramon

AU - Amstutz, Alain

AU - Bengough, Theresa

AU - Briel, Matthias

AU - Tikkinen, K. A.

PY - 2016/1

Y1 - 2016/1

KW - Randomized controlled trials

KW - Protocol

KW - Early termination of clinical trials

KW - Data monitoring committees

KW - Interim analysis

KW - Stopping Rules

KW - RANDOMIZED-TRIALS

KW - 3141 Health care science

KW - 3142 Public health care science, environmental and occupational health

U2 - 10.1016/j.jclinepi.2015.05.023

DO - 10.1016/j.jclinepi.2015.05.023

M3 - Review Article

VL - 69

SP - 152

EP - 160

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

SN - 0895-4356

ER -