An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis

Karo Talvio; Victoria A. Wagner; Rimante Minkeviciene; Jay S. Kirkwood; Anna O. Kulinich; Juzoh Umemori; Anil Bhatia; Manhoi Hur; Reijo Kakela; Iryna M. Ethell; Maija L. Castren

doi:10.1038/s42003-023-05147-9

An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis

Karo Talvio, Victoria A. Wagner, Rimante Minkeviciene, Jay S. Kirkwood, Anna O. Kulinich, Juzoh Umemori, Anil Bhatia, Manhoi Hur, Reijo Kakela, Iryna M. Ethell, Maija L. Castren

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Communications Biology
Volume	6
Issue number	1
Number of pages	11
ISSN	2399-3642
DOIs	https://doi.org/10.1038/s42003-023-05147-9
Publication status	Published - 29 Jul 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

3111 Biomedicine

Access to Document

10.1038/s42003-023-05147-9

s42003-023-05147-9Final published version, 2.52 MBLicence: CC BY

Cite this

@article{268643e074364a609e75502ebfcc888d,

title = "An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis",

keywords = "Polyunsaturated fatty-acids, Mediate cholesterol, Desmosterol, Supplementation, Accumulation, Metabolism, Abca1, Inflammation, Lovastatin, Chemokine, 3111 Biomedicine",

author = "Karo Talvio and Wagner, {Victoria A.} and Rimante Minkeviciene and Kirkwood, {Jay S.} and Kulinich, {Anna O.} and Juzoh Umemori and Anil Bhatia and Manhoi Hur and Reijo Kakela and Ethell, {Iryna M.} and Castren, {Maija L.}",

year = "2023",

month = jul,

day = "29",

doi = "10.1038/s42003-023-05147-9",

language = "English",

volume = "6",

journal = "Communications Biology",

issn = "2399-3642",

publisher = "Springer",

number = "1",

}

TY - JOUR

T1 - An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis

AU - Talvio, Karo

AU - Wagner, Victoria A.

AU - Minkeviciene, Rimante

AU - Kirkwood, Jay S.

AU - Kulinich, Anna O.

AU - Umemori, Juzoh

AU - Bhatia, Anil

AU - Hur, Manhoi

AU - Kakela, Reijo

AU - Ethell, Iryna M.

AU - Castren, Maija L.

PY - 2023/7/29

Y1 - 2023/7/29

KW - Polyunsaturated fatty-acids

KW - Mediate cholesterol

KW - Desmosterol

KW - Supplementation

KW - Accumulation

KW - Metabolism

KW - Abca1

KW - Inflammation

KW - Lovastatin

KW - Chemokine

KW - 3111 Biomedicine

U2 - 10.1038/s42003-023-05147-9

DO - 10.1038/s42003-023-05147-9

M3 - Article

C2 - 37516746

SN - 2399-3642

VL - 6

JO - Communications Biology

JF - Communications Biology

IS - 1

ER -