Analysis of canine gene constraint identifies new variants for orofacial clefts and stature

Reuben M. Buckley; Nuket Bilgen; Alexander C. Harris; Peter Savolainen; Cafer Tepeli; Metin Erdogan; Aitor Serres Armero; Dayna L. Dreger; Frank G. van Steenbeek; Marjo K. Hytönen; Heidi G. Parker; Jessica Hale; Hannes Lohi; Bengi Cinar Kul; Adam R. Boyko; Elaine A. Ostrander

doi:10.1101/gr.280092.124

Analysis of canine gene constraint identifies new variants for orofacial clefts and stature

Reuben M. Buckley, Nuket Bilgen, Alexander C. Harris, Peter Savolainen, Cafer Tepeli, Metin Erdogan, Aitor Serres Armero, Dayna L. Dreger, Frank G. van Steenbeek, Marjo K. Hytönen, Heidi G. Parker, Jessica Hale, Hannes Lohi, Bengi Cinar Kul, Adam R. Boyko, Elaine A. Ostrander

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Genome Research
Volume	35
Issue number	5
Pages (from-to)	1080-1093
Number of pages	14
ISSN	1088-9051
DOIs	https://doi.org/10.1101/gr.280092.124
Publication status	Published - May 2025
MoE publication type	A1 Journal article-refereed

Fields of Science

Dog breeds
Mutation
Model
Osteopetrosis
Selection
Growth
Association
Reveal
413 Veterinary science

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10.1101/gr.280092.124Licence: CC BY-NC

Genome Res.-2025-Buckley-1080-93Final published version, 6.54 MBLicence: CC BY-NC

Cite this

Buckley, R. M., Bilgen, N., Harris, A. C., Savolainen, P., Tepeli, C., Erdogan, M., Armero, A. S., Dreger, D. L., van Steenbeek, F. G., Hytönen, M. K., Parker, H. G., Hale, J., Lohi, H., Kul, B. C., Boyko, A. R., & Ostrander, E. A. (2025). Analysis of canine gene constraint identifies new variants for orofacial clefts and stature. Genome Research, 35(5), 1080-1093. https://doi.org/10.1101/gr.280092.124

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keywords = "Dog breeds, Mutation, Model, Osteopetrosis, Selection, Growth, Association, Reveal, 413 Veterinary science",

author = "Buckley, {Reuben M.} and Nuket Bilgen and Harris, {Alexander C.} and Peter Savolainen and Cafer Tepeli and Metin Erdogan and Armero, {Aitor Serres} and Dreger, {Dayna L.} and {van Steenbeek}, {Frank G.} and Hyt{\"o}nen, {Marjo K.} and Parker, {Heidi G.} and Jessica Hale and Hannes Lohi and Kul, {Bengi Cinar} and Boyko, {Adam R.} and Ostrander, {Elaine A.}",

year = "2025",

month = may,

doi = "10.1101/gr.280092.124",

language = "English",

volume = "35",

pages = "1080--1093",

journal = "Genome Research",

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Buckley, RM, Bilgen, N, Harris, AC, Savolainen, P, Tepeli, C, Erdogan, M, Armero, AS, Dreger, DL, van Steenbeek, FG, Hytönen, MK, Parker, HG, Hale, J, Lohi, H, Kul, BC, Boyko, AR & Ostrander, EA 2025, 'Analysis of canine gene constraint identifies new variants for orofacial clefts and stature', Genome Research, vol. 35, no. 5, pp. 1080-1093. https://doi.org/10.1101/gr.280092.124

TY - JOUR

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AU - Buckley, Reuben M.

AU - Bilgen, Nuket

AU - Harris, Alexander C.

AU - Savolainen, Peter

AU - Tepeli, Cafer

AU - Erdogan, Metin

AU - Armero, Aitor Serres

AU - Dreger, Dayna L.

AU - van Steenbeek, Frank G.

AU - Hytönen, Marjo K.

AU - Parker, Heidi G.

AU - Hale, Jessica

AU - Lohi, Hannes

AU - Kul, Bengi Cinar

AU - Boyko, Adam R.

AU - Ostrander, Elaine A.

PY - 2025/5

Y1 - 2025/5

KW - Dog breeds

KW - Mutation

KW - Model

KW - Osteopetrosis

KW - Selection

KW - Growth

KW - Association

KW - Reveal

KW - 413 Veterinary science

U2 - 10.1101/gr.280092.124

DO - 10.1101/gr.280092.124

M3 - Article

C2 - 40127928

SN - 1088-9051

VL - 35

SP - 1080

EP - 1093

JO - Genome Research

JF - Genome Research

IS - 5

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