Ancient mitogenomes from Pre-Pottery Neolithic Central Anatolia and the effects of a Late Neolithic bottleneck in sheep (Ovis aries)

Edson Sandoval-Castellanos, Andrew J. Hare, Audrey T. Lin, Evangelos A. Dimopoulos, Kevin G. Daly, Sheila Geiger, Victoria E. Mullin, Ingrid Wiechmann, Valeria Mattiangeli, Gesine Lühken, Natalia A. Zinovieva, Petar Zidarov, Canan Cakirlar, Simon Stoddart, David Orton, Jelena Bulatovic, Marjan Mashkour, Eberhard W. Sauer, Liora Kolska-Horwitz, Barbara HorejsLevent Atici, Vecihi Özkaya, Jacqui Mullville, Michael Parker Pearson, Ingrid Mainland, Nick Card, Lisa Brown, Niall Sharples, David Griffiths, David Allen, Benjamin Arbuckle, Jordan T. Abell, Güneş Duru, Susan M. Mentzer, Natalie D. Munro, M Uzdurum, Sevil Gülcur, Hijlke Buitenhuis, Elena Gladyr, Mary C. Stiner, Nadja Pöllath, Mihriban Özbasaran, Stefan Krebs, Joachim Burger, Laurent Frantz, Ivica Medugorac, Daniel G. Bradley, Joris Peters

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Occupied between ~10,300 and 9300 years ago, the Pre-Pottery Neolithic site of Aşıklı Höyük in Central Anatolia went through early phases of sheep domestication. Analysis of 629 mitochondrial genomes from this and numerous sites in Anatolia, southwest Asia, Europe, and Africa produced a phylogenetic tree with excessive coalescences(nodes) around the Neolithic, a potential signature of a domestication bottleneck. This is consistent with archeological evidence of sheep management at Aşıklı Höyük which transitioned from residential stabling to open pasturing over a millennium of site occupation. However, unexpectedly, we detected high genetic diversity throughout Aşıklı Höyük’s occupation rather than a bottleneck. Instead, we detected a tenfold demographic bottleneck later in the Neolithic, which caused the fixation of mitochondrial haplogroup B in southwestern Anatolia. The mitochondrial genetic makeup that emerged was carried from the core region of early Neolithic sheep management into Europe and dominates the matrilineal diversity of both its ancient and the billion-strong modern sheep populations.
Original languageEnglish
Article numbereadj0954
JournalScience Advances
Volume10
Issue number15
Number of pages14
ISSN2375-2548
DOIs
Publication statusPublished - 12 Apr 2024
Externally publishedYes
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 1184 Genetics, developmental biology, physiology
  • 1172 Environmental sciences
  • 413 Veterinary science
  • 615 History and Archaeology
  • 6160 Other humanities

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