Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old: a population-based autopsy study

Liisa Myllykangas, G. Alistair Lammie, Irma-Leena Notkola, Raimo Sulkava, Tuomo Polvikoski

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American Heart Association criteria, and classified into four different categories: pathological intimal thickening (PIT), fibrous cap atheromas (FCA), calcified lesions (CL), and atherosclerotic burden (AB) (a combination of the other three categories). APOE epsilon 4 genetic variant was associated with PIT (p = 0.018) and AB (p = 0.006) in the carotid arteries, and its effect was independent of the serum lipid levels. The genetic variant LPL Ser447Ter was protective against FCA (p = 0.031) and AB (p = 0.012), while APOE epsilon 2 was protective against FCA (p = 0.035). Our results suggest that the APOE epsilon 4, epsilon 2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
    Original languageEnglish
    JournalArchives of Gerontology and Geriatrics
    Volume49
    Issue number1
    Pages (from-to)108-112
    Number of pages5
    ISSN0167-4943
    DOIs
    Publication statusPublished - 2009
    MoE publication typeA1 Journal article-refereed

    Cite this

    @article{cd3f4b1c77534ff1bdf137115b8bdcc2,
    title = "Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old: a population-based autopsy study",
    abstract = "We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American Heart Association criteria, and classified into four different categories: pathological intimal thickening (PIT), fibrous cap atheromas (FCA), calcified lesions (CL), and atherosclerotic burden (AB) (a combination of the other three categories). APOE epsilon 4 genetic variant was associated with PIT (p = 0.018) and AB (p = 0.006) in the carotid arteries, and its effect was independent of the serum lipid levels. The genetic variant LPL Ser447Ter was protective against FCA (p = 0.031) and AB (p = 0.012), while APOE epsilon 2 was protective against FCA (p = 0.035). Our results suggest that the APOE epsilon 4, epsilon 2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.",
    author = "Liisa Myllykangas and Lammie, {G. Alistair} and Irma-Leena Notkola and Raimo Sulkava and Tuomo Polvikoski",
    year = "2009",
    doi = "10.1016/j.archger.2008.05.007",
    language = "English",
    volume = "49",
    pages = "108--112",
    journal = "Archives of Gerontology and Geriatrics",
    issn = "0167-4943",
    publisher = "ELSEVIER IRELAND LTD",
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    Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old : a population-based autopsy study. / Myllykangas, Liisa; Lammie, G. Alistair; Notkola, Irma-Leena; Sulkava, Raimo; Polvikoski, Tuomo.

    In: Archives of Gerontology and Geriatrics, Vol. 49, No. 1, 2009, p. 108-112.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old

    T2 - a population-based autopsy study

    AU - Myllykangas, Liisa

    AU - Lammie, G. Alistair

    AU - Notkola, Irma-Leena

    AU - Sulkava, Raimo

    AU - Polvikoski, Tuomo

    PY - 2009

    Y1 - 2009

    N2 - We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American Heart Association criteria, and classified into four different categories: pathological intimal thickening (PIT), fibrous cap atheromas (FCA), calcified lesions (CL), and atherosclerotic burden (AB) (a combination of the other three categories). APOE epsilon 4 genetic variant was associated with PIT (p = 0.018) and AB (p = 0.006) in the carotid arteries, and its effect was independent of the serum lipid levels. The genetic variant LPL Ser447Ter was protective against FCA (p = 0.031) and AB (p = 0.012), while APOE epsilon 2 was protective against FCA (p = 0.035). Our results suggest that the APOE epsilon 4, epsilon 2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    AB - We investigated the association between histologically defined atherosclerotic lesions in the carotid arteries and the genetic variants of APOE and LPL in a population-based sample of Finns aged 85 or over. Post-mortem analysis of carotid arteries was performed in 240 subjects. Atherosclerotic lesions were categorized according to the modified American Heart Association criteria, and classified into four different categories: pathological intimal thickening (PIT), fibrous cap atheromas (FCA), calcified lesions (CL), and atherosclerotic burden (AB) (a combination of the other three categories). APOE epsilon 4 genetic variant was associated with PIT (p = 0.018) and AB (p = 0.006) in the carotid arteries, and its effect was independent of the serum lipid levels. The genetic variant LPL Ser447Ter was protective against FCA (p = 0.031) and AB (p = 0.012), while APOE epsilon 2 was protective against FCA (p = 0.035). Our results suggest that the APOE epsilon 4, epsilon 2 and LPL Ser447Ter variants may have different roles in the atherosclerotic process and their effects are seen even in the oldest old population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    U2 - 10.1016/j.archger.2008.05.007

    DO - 10.1016/j.archger.2008.05.007

    M3 - Article

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    EP - 112

    JO - Archives of Gerontology and Geriatrics

    JF - Archives of Gerontology and Geriatrics

    SN - 0167-4943

    IS - 1

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