Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

Amy K. Holt; Arafath K. Najumudeen; Tracey J. Collard; Hao Li; Laura M. Millett; Ashley J. Hoskin; Danny N. Legge; Eleanor M. H. Mortensson; Dustin J. Flanagan; Nicholas Jones; Madhu Kollareddy; Penny Timms; Matthew D. Hitchings; James Cronin; Owen J. Sansom; Ann C. Williams; Emma E. Vincent

doi:10.1186/s40170-023-00318-y

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

Amy K. Holt, Arafath K. Najumudeen, Tracey J. Collard, Hao Li, Laura M. Millett, Ashley J. Hoskin, Danny N. Legge, Eleanor M. H. Mortensson, Dustin J. Flanagan, Nicholas Jones, Madhu Kollareddy, Penny Timms, Matthew D. Hitchings, James Cronin, Owen J. Sansom, Ann C. Williams, Emma E. Vincent

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	18
Journal	Cancer & Metabolism
Volume	11
Number of pages	19
ISSN	2049-3002
DOIs	https://doi.org/10.1186/s40170-023-00318-y
Publication status	Published - 19 Oct 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

Aspirin
Cb-839
Colorectal cancer
Glutaminase
Metabolic reprogramming
Metabolism
1182 Biochemistry, cell and molecular biology

Access to Document

10.1186/s40170-023-00318-yLicence: CC BY

s40170-023-00318-yFinal published version, 5.14 MBLicence: CC BY

Cite this

Holt, A. K., Najumudeen, A. K., Collard, T. J., Li, H., Millett, L. M., Hoskin, A. J., Legge, D. N., Mortensson, E. M. H., Flanagan, D. J., Jones, N., Kollareddy, M., Timms, P., Hitchings, M. D., Cronin, J., Sansom, O. J., Williams, A. C., & Vincent, E. E. (2023). Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition. Cancer & Metabolism, 11, Article 18. https://doi.org/10.1186/s40170-023-00318-y

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title = "Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition",

keywords = "Aspirin, Cb-839, Colorectal cancer, Glutaminase, Metabolic reprogramming, Metabolism, 1182 Biochemistry, cell and molecular biology",

author = "Holt, {Amy K.} and Najumudeen, {Arafath K.} and Collard, {Tracey J.} and Hao Li and Millett, {Laura M.} and Hoskin, {Ashley J.} and Legge, {Danny N.} and Mortensson, {Eleanor M. H.} and Flanagan, {Dustin J.} and Nicholas Jones and Madhu Kollareddy and Penny Timms and Hitchings, {Matthew D.} and James Cronin and Sansom, {Owen J.} and Williams, {Ann C.} and Vincent, {Emma E.}",

year = "2023",

month = oct,

day = "19",

doi = "10.1186/s40170-023-00318-y",

language = "English",

volume = "11",

journal = "Cancer & Metabolism",

issn = "2049-3002",

publisher = "BioMed Central Ltd",

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Holt, AK, Najumudeen, AK, Collard, TJ, Li, H, Millett, LM, Hoskin, AJ, Legge, DN, Mortensson, EMH, Flanagan, DJ, Jones, N, Kollareddy, M, Timms, P, Hitchings, MD, Cronin, J, Sansom, OJ, Williams, AC & Vincent, EE 2023, 'Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition', Cancer & Metabolism, vol. 11, 18. https://doi.org/10.1186/s40170-023-00318-y

TY - JOUR

T1 - Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

AU - Holt, Amy K.

AU - Najumudeen, Arafath K.

AU - Collard, Tracey J.

AU - Li, Hao

AU - Millett, Laura M.

AU - Hoskin, Ashley J.

AU - Legge, Danny N.

AU - Mortensson, Eleanor M. H.

AU - Flanagan, Dustin J.

AU - Jones, Nicholas

AU - Kollareddy, Madhu

AU - Timms, Penny

AU - Hitchings, Matthew D.

AU - Cronin, James

AU - Sansom, Owen J.

AU - Williams, Ann C.

AU - Vincent, Emma E.

PY - 2023/10/19

Y1 - 2023/10/19

KW - Aspirin

KW - Cb-839

KW - Colorectal cancer

KW - Glutaminase

KW - Metabolic reprogramming

KW - Metabolism

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1186/s40170-023-00318-y

DO - 10.1186/s40170-023-00318-y

M3 - Article

C2 - 37858256

SN - 2049-3002

VL - 11

JO - Cancer & Metabolism

JF - Cancer & Metabolism

M1 - 18

ER -