Assessment of PINK1 (PARK6) polymorphisms in Finnish PD

Jordi Clarimon; Johanna Eerola-Rautio; Olli Hellström; Terhi Peuralinna; Pentti J Tienari; Andrew B Singleton

doi:10.1016/j.neurobiolaging.2005.03.028

Assessment of PINK1 (PARK6) polymorphisms in Finnish PD

Jordi Clarimon, Johanna Eerola-Rautio, Olli Hellström, Terhi Peuralinna, Pentti J Tienari, Andrew B Singleton

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Recent data has demonstrated that mutations in PINK], encoding PTEN-induced kinase 1, are a cause of early onset recessive parkinsonism (PARK6 locus). Common variability in genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). We analyzed whether six different genetic variants within and surrounding PINK] contribute to the risk of sporadic PD in a Finnish case-control series. Our results indicate that this gene does not play a major role in the genetic predisposition to PD in this population. (c) 2005 Elsevier Inc. All rights reserved.

Original language	English
Journal	Neurobiology of Aging
Volume	27
Issue number	6
Pages (from-to)	906-907
Number of pages	2
ISSN	0197-4580
DOIs	https://doi.org/10.1016/j.neurobiolaging.2005.03.028
Publication status	Published - 2006
MoE publication type	A1 Journal article-refereed

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10.1016/j.neurobiolaging.2005.03.028

Cite this

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title = "Assessment of PINK1 (PARK6) polymorphisms in Finnish PD",

abstract = "Recent data has demonstrated that mutations in PINK], encoding PTEN-induced kinase 1, are a cause of early onset recessive parkinsonism (PARK6 locus). Common variability in genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). We analyzed whether six different genetic variants within and surrounding PINK] contribute to the risk of sporadic PD in a Finnish case-control series. Our results indicate that this gene does not play a major role in the genetic predisposition to PD in this population. (c) 2005 Elsevier Inc. All rights reserved.",

author = "Jordi Clarimon and Johanna Eerola-Rautio and Olli Hellstr{\"o}m and Terhi Peuralinna and Tienari, {Pentti J} and Singleton, {Andrew B}",

year = "2006",

doi = "10.1016/j.neurobiolaging.2005.03.028",

language = "English",

volume = "27",

pages = "906--907",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc. ",

number = "6",

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T1 - Assessment of PINK1 (PARK6) polymorphisms in Finnish PD

AU - Clarimon, Jordi

AU - Eerola-Rautio, Johanna

AU - Hellström, Olli

AU - Peuralinna, Terhi

AU - Tienari, Pentti J

AU - Singleton, Andrew B

PY - 2006

Y1 - 2006

N2 - Recent data has demonstrated that mutations in PINK], encoding PTEN-induced kinase 1, are a cause of early onset recessive parkinsonism (PARK6 locus). Common variability in genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). We analyzed whether six different genetic variants within and surrounding PINK] contribute to the risk of sporadic PD in a Finnish case-control series. Our results indicate that this gene does not play a major role in the genetic predisposition to PD in this population. (c) 2005 Elsevier Inc. All rights reserved.

AB - Recent data has demonstrated that mutations in PINK], encoding PTEN-induced kinase 1, are a cause of early onset recessive parkinsonism (PARK6 locus). Common variability in genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). We analyzed whether six different genetic variants within and surrounding PINK] contribute to the risk of sporadic PD in a Finnish case-control series. Our results indicate that this gene does not play a major role in the genetic predisposition to PD in this population. (c) 2005 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.neurobiolaging.2005.03.028

DO - 10.1016/j.neurobiolaging.2005.03.028

M3 - Article

SN - 0197-4580

VL - 27

SP - 906

EP - 907

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 6

ER -